A red lysosome-targeted fluorescent probe for carboxylesterase detection and bioimaging

Zhou, Hui; Tang, Jin‐Bao; Zhang, Jie; Chen, Bochao; Kan, Jianfei; Zhang, Weifen; Zhou, Jin; Ma, Huimin

doi:10.1039/c9tb00310j

Cited by 54 publications

(29 citation statements)

References 52 publications

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“…In 2019, Zhou's group reported a red emission lysosome‐targeted probe 6 . It is a fluorescence “off‐on” probe with the ability to selectively and sensitively detect carboxylesterase in living cells, sera as well as tissues (Figure e).…”

Section: Classification and Functions Of Cessmentioning

confidence: 99%

A Minireview of Recent Reported Carboxylesterase Fluorescent Probes: Design and Biological Applications

Dai

Hou

et al. 2020

ChemistrySelect

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As the most important members of serine esterase hydrolase superfamily, mammalian carboxylesterases (CESs) are widely distributed in various tissues like liver, intestine, lung and kidney. Many physiological processes require the hydrolysis of CES with a variety of endogenous and exogenous ester drugs and environmental poisons. So, developing the methods that can detect CESs activity is of great significance. In last decades, huge breakthrough has been made in the development of specific detection technologies including chromatography, quantitative reverse transcription polymerase chain reaction (qRT-PCR), proteomics and western blotting. However, these traditional methods for CESs detection have little effect on the spatiotemporal distribution and in situ activity of CES in living cells and in vivo. Compared with that, fluorogenic methods have been developed for real-time monitoring CESs in biological environments. In this review, we summarized the recent reported CESs probes. The designing strategies as well as their applications are reviewed. We hope this review will inspire the development of novel specific CESs fluorescent probes.

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Section: Classification and Functions Of Cessmentioning

confidence: 99%

A Minireview of Recent Reported Carboxylesterase Fluorescent Probes: Design and Biological Applications

Dai

Hou

et al. 2020

ChemistrySelect

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“…Nanoprobes, as novel kinds of contrast agents, have been extensively used in medical imaging and drug delivery given their size and optical properties, which translate to high resolution, sensitivity and other advantages 4 - 8 . The nanoprobes with imaging abilities are especially suitable for real-time imaging, which could greatly improve the accuracy of early tumor diagnosis and therapeutic monitoring 9 , 10 . In fact, several nanoprobes have been designed in recent years for the early diagnosis and monitoring of tumors 11 .…”

Section: Introductionmentioning

confidence: 99%

Tumor immunotherapy and multi-mode therapies mediated by medical imaging of nanoprobes

Yang¹,

Guan²,

Zhang³

2021

Theranostics

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Immunotherapy is an effective tumor treatment strategy that has several advantages over conventional methods such as surgery, radiotherapy and chemotherapy. Studies show that multifunctional nanoprobes can achieve multi-mode image-guided multiple tumor treatment modes. The tumor cells killed by chemotherapies or phototherapies release antigens that trigger an immune response and augment the effects of tumor immunotherapy. Thus, combining immunotherapy and multifunctional nanoprobes can achieve early cancer diagnosis and treatment. In this review, we have summarized the current research on the applications of multifunctional nanoprobes in image-guided immunotherapy. In addition, image-guided synergistic chemotherapy/photothermal therapy/photodynamic therapy and immunotherapy have also been discussed. Furthermore, the application potential and clinical prospects of multifunctional nanoprobes in combination with immunotherapy have been assessed.

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“…[23][24][25][26] For example, Zhou et al reported a new lysosome-targeted uorescence probe with emission 575 nm for uorescence sensing of carboxylesterase in live cells, sera and tissues. 27 As for in vivo imaging studies, near-infrared (NIR) uorescent probes are more desired because they have excellent tissue penetration, low biological and autouorescence damage. [28][29][30][31][32] As far as we know, most of the current probes have a severe limitation on application for imaging in living systems, since they have a short excitation (usually <500 nm) and emission wavelength (usually <630 nm) and there are limited reports on NIR uorescent probes for carboxylesterase detection in recent years.…”

Section: Introductionmentioning

confidence: 99%

Detection of carboxylesterase by a novel hydrosoluble near-infrared fluorescence probe

Zhai

Wang

et al. 2019

RSC Adv.

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A red lysosome-targeted fluorescent probe for carboxylesterase detection and bioimaging

Abstract: A red lysosome-targeting probe for carboxylesterase activity has been successfully applied in complex biological samples.

Cited by 54 publications

References 52 publications

A Minireview of Recent Reported Carboxylesterase Fluorescent Probes: Design and Biological Applications

A Minireview of Recent Reported Carboxylesterase Fluorescent Probes: Design and Biological Applications

Tumor immunotherapy and multi-mode therapies mediated by medical imaging of nanoprobes

Detection of carboxylesterase by a novel hydrosoluble near-infrared fluorescence probe

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