A red luminescent europium metal organic framework (Eu-MOF) integrated with a paper strip using smartphone visual detection for determination of folic acid in pharmaceutical formulations

Kayani, Kawan F.; Omer, Khalid M.

doi:10.1039/d2nj00601d

Cited by 35 publications

(17 citation statements)

References 88 publications

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“…In addition, previous studies on FA detection were summarized. − As depicted in Table S1, this work provides a low detection limit and high detection sensitivity, and the operation is simple, fast, and feasible. Therefore, 1 can be considered a unique recyclable detection platform for d -FA and l -FA.…”

Section: Results and Discussionmentioning

confidence: 99%

Chiral Carbon Quantum Dots Encapsulated in ZIF-8 Nanoparticles for Turn-On Recognition of Chiral Folic Acid and Nitrofurazone and Applications as Fluorescent Inks

Liu

Geng

Wang

et al. 2022

ACS Appl. Nano Mater.

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Metal−organic frameworks (MOFs) are a kind of nanoporous coordination materials, which have the advantages of high crystallinity and tunable functionalization. Carbon dots (CDs) are zerodimensional luminescent carbon nanomaterials, which combine the advantages of small organic molecules such as fluorophores and conventional semiconductors such as inorganic quantum dots. Chiral quantum dots are appealing for detection of chiral substances due to their unique chirality. In this work, chiral CDs can be loaded into zeolitic imidazolate framework-8 (ZIF-8) via an in situ encapsulation method, forming the chiral composite hybrid material CCQDs/ZIF-8 (1). The framework structure and luminescent property of 1 can be maintained after being soaked in water and ethanol for 24 h as confirmed by PXRD characterization. A luminescent experiment demonstrated that 1 can be utilized as a highly sensitive and selective "turn-on" fluorescent probe of Dfolic acid (K BH 9.82 × 10 4 M −1 and detection limit 0.31 μM) and L-folic acid (K BH 2.99 × 10 4 M −1 and detection limit 4.36 μM). 1 also shows good cycling detection performance for D-folic acid (94.96%) and L-folic acid (93.69%). Enantioselective identification between D-folic acid and L-folic acid (K D /K L = 3.28) can be carried out. Furthermore, simultaneously, 1 can be used as an efficient turn-on fluorescence probe to detect the antibiotic nitrofurazone (NFZ; K BH 3.29 × 10 4 M −1 and detection limit 3.06 μM). Further, 1 can be utilized to detect folic acid and NFZ in real samples. The results demonstrated that 1 can be used as a highly efficient turnon detection platform for folic acid and NFZ. Further, 1 with these targeted objects can be successfully applied as a fluorescent ink; a mixed-matrix membrane based on 1 has been prepared. The detection mechanism of composite material 1 for recognition of folic acid and NFZ is also investigated and discussed.

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Section: Results and Discussionmentioning

confidence: 99%

Chiral Carbon Quantum Dots Encapsulated in ZIF-8 Nanoparticles for Turn-On Recognition of Chiral Folic Acid and Nitrofurazone and Applications as Fluorescent Inks

Liu

Geng

Wang

et al. 2022

ACS Appl. Nano Mater.

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“…21 In the literature, for the construction of intrinsic LMOFs, lanthanide elements, such as Eu 3+ and Tb 3+ are used. 14,16,22,23 Such elements have higher costs, potential supply shortages, and adverse effects on the environment. Therefore, it is worthwhile, yet challenging, to design low-cost, biocompatible, and safe intrinsic LMOFs.…”

Section: Introductionmentioning

confidence: 99%

Intrinsic Dual-State Emission Zinc-Based MOF Rodlike Nanostructures with Applications in Smartphone Readout Visual-Based Detection for Tetracycline: MOF-Based Color Tonality

Mohammed Ameen,

Qasim,

Alhasan

et al. 2023

ACS Appl. Mater. Interfaces

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Dual-state emitters (DSEs) are entities that exhibit fluorescence in both the solution and solid state, which open up a wide range of possibilities for their utilization in various fields. The development of detection platforms using intrinsic luminescent metal–organic frameworks (LMOFs) is highly desirable for a variety of applications. DSE MOFs as a subclass of intrinsic LMOFs are highly attractive due to no need for encapsulation/functionalization by fluorophores and/or using luminescent linkers. Herein, a highly stable intrinsic dual-state blue emission (λem = 425 nm) zinc-based MOF with rodlike nanostructures (denoted as UoZ-2) was synthesized and characterized. To the best of our knowledge, intrinsic DSE of Zn-MOFs with blue emission in the dispersed form in solution and solid-state fluorescence have not been reported yet. When tetracycline (TC) was added, a continuous color evolution from blue to greenish-yellow with dramatic enhancement was observed due to aggregation induced emission (AIE). Thus, a sensitive ratiometry-based visual detection platform, in solution and on paper independently, was designed for detection of TC exploiting the DSE and AIE properties of UoZ-2 alone and UoZ-2:TC. The detection limit was estimated to be 4.5 nM, which is considered to be one of the most sensitive ratiometric fluorescent probes for TC sensing. The ratiometry paper-based UoZ-2 sensor displays a reliable TC quantitative analysis by recognizing RGB values in the on-site TC detection with satisfactory recoveries.

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“…They are expected to be a new luminescent material that produce a fluorescence response after the introduction of target analytes. At the same time, portable sensor probes (such as fluorescent sensor films, − hydrogel sensors, , paper-based sensors based on smartphone, − etc.) as field analysis technology are very popular in the real-time analysis of target analytes and visual monitoring.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of the Antibiotic Sensor by the Multifunctional Stable Adjustable Luminescent Lanthanide Metal–Organic Frameworks

Wang

Yang

et al. 2023

Inorg. Chem.

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In recent years, the irrational use of antibiotics has become very widespread. It is necessary to regulate this phenomenon through antibiotic detection. In this work, a series of isomorphic Ln-MOFs (Ln = Tb3+ and Eu3+) were synthesized from 1,3,5-tri(4-carboxyphenyl)benzene (H3L) and Ln3+ by the solvothermal method for the first time. A series of 1-Eu x Tb 1–x with different luminescence were doped by changing the molar ratio of Tb3+ and Eu3+. Ln3+ forms a 4-connected 2D network structure through self-assembly with fully deprotonated L3–. It shows good chemical stability in water, and its luminescence is not affected by aqueous solutions with different pH values. 1-Eu demonstrates rapid and sensitive detection capabilities for MDZ and TET with good recyclability and low detection limits (10–5). In order to increase the practicability of 1-Eu, two portable sensors have been prepared, in which the fluorescent film (Film@1-Eu) has a detection limit of 10–4, and the sensitivity is only less than 10% of the titration results. A portable fluorescent test paper can reach the detection limit of 14.7 ppm. This study provides a new idea for the application of stable multifunctional materials in the field of fluorescence sensing.

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A red luminescent europium metal organic framework (Eu-MOF) integrated with a paper strip using smartphone visual detection for determination of folic acid in pharmaceutical formulations

Abstract: Integration of smartphone with visual-based paper strip as a low-cost, fast, and reliable probe for semi-quantitative analysis of folic acid.

Cited by 35 publications

References 88 publications

Chiral Carbon Quantum Dots Encapsulated in ZIF-8 Nanoparticles for Turn-On Recognition of Chiral Folic Acid and Nitrofurazone and Applications as Fluorescent Inks

Chiral Carbon Quantum Dots Encapsulated in ZIF-8 Nanoparticles for Turn-On Recognition of Chiral Folic Acid and Nitrofurazone and Applications as Fluorescent Inks

Intrinsic Dual-State Emission Zinc-Based MOF Rodlike Nanostructures with Applications in Smartphone Readout Visual-Based Detection for Tetracycline: MOF-Based Color Tonality

Fabrication of the Antibiotic Sensor by the Multifunctional Stable Adjustable Luminescent Lanthanide Metal–Organic Frameworks

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