A red-emitting mitochondria targetable fluorescent probe for detecting viscosity in HeLa, zebrafish, and mice

Gong, Xi; Guo, Rui; Li, Xiaoya; Yang, Yingjie; Lin, Weiying

doi:10.1039/d3ay01488f

Cited by 2 publications

(4 citation statements)

References 37 publications

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“…This is a problem for biologists and biophysicists. Microviscosity can indicate the condition of living cells [24]. It is closely linked to numerous diseases [23,24].…”

Section: Microviscosity Of Complex Liquidsmentioning

confidence: 99%

“…Microviscosity can indicate the condition of living cells [24]. It is closely linked to numerous diseases [23,24]. It is necessary to design tools to effectively monitor η micro changes, which could provide promising avenues for treating diseases.…”

Section: Microviscosity Of Complex Liquidsmentioning

confidence: 99%

“…Biological experiments showed that P could target mitochondria and detect viscosity alterations in HeLa cells. (HeLa cells are the first immortal human cell line [24]). Moreover, P allows the exploration of fluctuations in η micro within living organisms [24].…”

Section: Microviscosity Of Complex Liquidsmentioning

confidence: 99%

“…(HeLa cells are the first immortal human cell line [24]). Moreover, P allows the exploration of fluctuations in η micro within living organisms [24].…”

Section: Microviscosity Of Complex Liquidsmentioning

confidence: 99%

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Fast Recombination of Free Radicals in Solution and Microviscosity

Khudyakov

2024

Physchem

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Rates of fast reactions are inversely proportional to the solvent viscosity (η). However, a quantitative study demonstrates that dynamic viscosity η is often a crude reflection of a viscous drug exerted on a molecule or radical. This paper aims to present an accurate dependence of the rates of fast bi- and monomolecular reactions upon the viscous drug of a media. Different correction coefficients fmicro are discussed, which should lead to a dependence rate ∝ (fmicroη)−1. Microviscosity is viscosity, leading to the expected rate dependence upon shear viscosity. In many cases, experimentally measured diffusion coefficients of molecules of a similar structure to the reactive radicals lead to the correct prediction of radicals’ diffusion coefficients and the rate constants of radicals recombination. Microviscosity of complex non-Newtonian liquids (biological liquids, polymeric solutions) can be measured using low MW molecular probes. Usually, the measured ηmicro is much lower than the shear η of complex biological or polymeric liquids. Cis–trans isomerization of bulky groups in monomolecular reactions is often described with Kramers’ theory. An example of such isomerization of a cyanine dye studied experimentally and theoretically is presented. It is demonstrated in the selected case that Kramers’ theory adequately describes the dependence of cis–trans isomerization of organic compounds upon η.

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“…This is a problem for biologists and biophysicists. Microviscosity can indicate the condition of living cells [24]. It is closely linked to numerous diseases [23,24].…”

Section: Microviscosity Of Complex Liquidsmentioning

confidence: 99%

Section: Microviscosity Of Complex Liquidsmentioning

confidence: 99%

Section: Microviscosity Of Complex Liquidsmentioning

confidence: 99%

“…(HeLa cells are the first immortal human cell line [24]). Moreover, P allows the exploration of fluctuations in η micro within living organisms [24].…”

Section: Microviscosity Of Complex Liquidsmentioning

confidence: 99%

See 2 more Smart Citations

Fast Recombination of Free Radicals in Solution and Microviscosity

Khudyakov

2024

Physchem

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Recent advances in Alzheimer’s disease: Mechanisms, clinical trials and new drug development strategies

Zhang,

Wang

et al. 2024

Sig Transduct Target Ther

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Alzheimer’s disease (AD) stands as the predominant form of dementia, presenting significant and escalating global challenges. Its etiology is intricate and diverse, stemming from a combination of factors such as aging, genetics, and environment. Our current understanding of AD pathologies involves various hypotheses, such as the cholinergic, amyloid, tau protein, inflammatory, oxidative stress, metal ion, glutamate excitotoxicity, microbiota-gut-brain axis, and abnormal autophagy. Nonetheless, unraveling the interplay among these pathological aspects and pinpointing the primary initiators of AD require further elucidation and validation. In the past decades, most clinical drugs have been discontinued due to limited effectiveness or adverse effects. Presently, available drugs primarily offer symptomatic relief and often accompanied by undesirable side effects. However, recent approvals of aducanumab (1) and lecanemab (2) by the Food and Drug Administration (FDA) present the potential in disrease-modifying effects. Nevertheless, the long-term efficacy and safety of these drugs need further validation. Consequently, the quest for safer and more effective AD drugs persists as a formidable and pressing task. This review discusses the current understanding of AD pathogenesis, advances in diagnostic biomarkers, the latest updates of clinical trials, and emerging technologies for AD drug development. We highlight recent progress in the discovery of selective inhibitors, dual-target inhibitors, allosteric modulators, covalent inhibitors, proteolysis-targeting chimeras (PROTACs), and protein-protein interaction (PPI) modulators. Our goal is to provide insights into the prospective development and clinical application of novel AD drugs.

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A red-emitting mitochondria targetable fluorescent probe for detecting viscosity in HeLa, zebrafish, and mice

Abstract: Viscosity, an essential parameter of the cellular microenvironment, has the ability to indicate the condition of living cells. It is closely linked to numerous diseases like Alzheimer's disease, diabetes, and...

Cited by 2 publications

References 37 publications

Fast Recombination of Free Radicals in Solution and Microviscosity

Fast Recombination of Free Radicals in Solution and Microviscosity

Recent advances in Alzheimer’s disease: Mechanisms, clinical trials and new drug development strategies

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