For the palletizing robot's operating characteristics of high speed, high acceleration, and heavy load, it is necessary to make a research on the structure optimization focusing on the vibration characteristics according to the mechanical and dynamic performance analysis. This article first introduces the mechanical feature and working principle of high-speed and heavy-load robot palletizer. Kinematics analysis is carried out by using D-H parameter method, which obtains positive kinematics solution and workspace. Jacobian matrix is deduced, and the relationship between joint space and Cartesian space is established. Second, for the reason that joint flexibility has a great influence on the vibration performance of the robot, a rigid-flexible coupling dynamic model is established based on the simplified model of the flexible reducer and Lagrange's second equation to describe the joint flexibility of high-speed and heavy-load palletizing robot, and the vibration modes of the robot are analyzed. The influence of different joint stiffness on the frequency response of the system reveals the inherent properties of the heavy-load palletizing robot, which provides a theoretical basis for the optimal design and control of the heavy-load palletizing robot. Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).With the wide application of high-speed and heavy-load palletizing robots in automobile, metallurgy, and logistics industries, automated production lines put forward higher requirements for the speed, load capacity, acceleration, and positioning accuracy of robots. The high-speed and heavy-load palletizing robot not only reduces the positioning accuracy of the palletizing robot but also limits the speed of the robot. 1,2 In view of the high-speed, high-acceleration, and heavyload working characteristics of high-speed and heavy-load palletizing robot, it is not enough to complete structural analysis only at the kinematics level. It is necessary to carry out dynamic analysis of the robot body.Many achievements have been made in the study of flexible models. Bridges and Dawson 3 took into account the non-linear flexibility such as transmission friction, which made the flexible joint model more appropriate. On the basis of considering the non-linear links including backlash, Murphy et al. 4 established a complete flexible dynamic model of the robot by using Newton Euler method. For typical harmonic drive, Ghorbel and colleagues 5,6 established the model of harmonic reducer and verified the influence of reducer flexibility on motion through theoretical and experimental analysis. Hong and colleagues 7-9 used the basic principle of continuum ...