Abstract:Matriptase is an epithelial-derived type-II transmembrane serine protease. This protease is expressed prominently in the villus tip of smallintestinal epithelia at which senescent cells undergo shedding and/or apoptosis. The basement membrane of epithelial cells, including small-intestinal epithelial cells, contains extracellular matrix (ECM) proteins such as fibronectin and laminin. We found previously that high concentrations of a recombinant matriptase catalytic domain (r-MatCD) (e.g. 1 lM) caused an increa… Show more
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