A Recombinant Human Adenovirus Vaccine against Rabies

Prevec, Ludvik; Campbell, James B.; Christie, B.; Belbeck, L.; Graham, Frank L.

doi:10.1093/infdis/161.1.27

Cited by 128 publications

(62 citation statements)

References 14 publications

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“…Adenoviruses are distributed worldwide and infections with human adenovirus serotype 5 do not result in serious disease (Rowe et al, 1955;Andiman and Miller, 1982;Charlton et al, 1992;Russell, 1998). Human adenoviruses are currently being utilized in vaccine development due to their genetic stability and ability to be grown to high titers in a variety of cell types (Prevec et al, 1990), and they are being considered to serve as vectors for human vaccination and gene therapy (Bonnekoh et al, 1998;MolinierFrenkel et al, 2000;Flotte, 2004). There are no perceived environmental or public heath impacts of distributing ONRABH in Ontario, or elsewhere, because the vaccine has been extensively safety tested and as shown in this study there were very few human or companion animal contacts with the vaccine and no adverse reactions noted.…”

Section: Discussionmentioning

confidence: 99%

AERIAL DISTRIBUTION OF ONRAB^® BAITS AS A TACTIC TO CONTROL RABIES IN RACCOONS AND STRIPED SKUNKS IN ONTARIO, CANADA

Rosatte

Donovan

Davies

et al. 2009

Journal of Wildlife Diseases

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ABSTRACT:During August 2006 and 2007, baits containing oral rabies vaccine, live adenovirus vector, known as ONRABH, were aerially distributed in SW Ontario, Canada. Bait acceptance during 2006 was 62 and 74% in raccoons (Procyon lotor) in areas baited at 150 baits/km 2 and 75 and 77% in plots baited at 300 baits/km 2 . During 2007, bait acceptance for raccoons ranged between 59% and 80%, and 83% and 87%, in areas baited at 75 and 400 baits/km 2 , respectively. Bait acceptance by skunks varied among plots (5-24%). Rabies virus-specific seroconversion during 2006 averaged 66 and 81% in raccoons in areas baited at 150 and 300 baits/km 2 , respectively. During 2007, seroconversion by raccoons was 76 and 84% in areas baited at 75 and 400 baits/km 2 , respectively. Seroconversion by skunks varied among plots (17-51%). Vaccine efficacy, as judged by the percentage of animals that consumed a bait and seroconverted, averaged 79 and 87% during 2006 for raccoons in areas baited at 150 and 300 baits/km 2 , respectively, and 81 and 90% in areas baited during 2007 at 75 and 400 baits/km 2 , respectively. Because tetracycline marking was poor in skunks, an estimate of vaccine efficacy was not possible. Aerial distribution of ONRABH vaccine baits seems to be a feasible tactic for controlling rabies in skunks and raccoons.

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Section: Discussionmentioning

confidence: 99%

AERIAL DISTRIBUTION OF ONRAB^® BAITS AS A TACTIC TO CONTROL RABIES IN RACCOONS AND STRIPED SKUNKS IN ONTARIO, CANADA

Rosatte

Donovan

Davies

et al. 2009

Journal of Wildlife Diseases

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“…Most of the past efforts focused on human Ads, such as those of the common serotype 5 (AdHu5), which cause mild upper respiratory symptoms upon natural infections. Both replication competent 9,10 and E1-deleted (DE1) replication-defective AdHu5 vectors have been developed as vaccine carriers and have shown efficacy in mice, 11 dogs 12,13 and nonhuman primates (NHPs). 7 E1-deleted AdHu5 vectors also performed well in clinical trials.…”

Section: Introductionmentioning

confidence: 99%

Chimpanzee-origin adenovirus vectors as vaccine carriers

et al. 2005

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Vaccines based on replication-defective adenoviral vectors are being developed for infectious agents and tumorassociated antigens. Early work focused on vaccines derived from a common human serotype of adenovirus, that is, adenovirus of the serotype 5 (AdHu5). Neutralizing antibodies against AdHu5 virus, present in a large percentage of the human population, dampen the efficacy of vaccines based on this carrier. To circumvent this problem, we generated vectors derived from chimpanzee adenoviruses.Here we describe some basic parameters of vectors derived from chimpanzee adenoviruses C68 and C7, including growth characteristics, yields of infectious particles, effects of additional deletions in E3 and E4 and lengths of the inserted foreign sequence as they relate to the suitability for their eventual development as vaccine carriers for clinical use.

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“…The potential of various adenoviruses as vectors for recombinant virus vaccines and somatic gene therapy is currently being extensively investigated (Chanda et al, 1990;Graham, 1990;Prevec et al, 1990;Rosenfeld et al, 1992;Mittal et al, 1994Mittal et al, , 1995Ragot et al, 1993;Engelhardt et al, 1994). Most of these studies are based on the use of human adenovirus type 5 (HAd5) as a foreign gene expression vector in mammalian cells.…”

Section: Introductionmentioning

confidence: 99%

Pathology and immunogenicity in the cotton rat (Sigmodon hispidus) model after infection with a bovine adenovirus type 3 recombinant virus expressing the firefly luciferase gene

Mittal

Middleton²,

Tikoo³

et al. 1996

Journal of General Virology

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A Recombinant Human Adenovirus Vaccine against Rabies

Cited by 128 publications

References 14 publications

AERIAL DISTRIBUTION OF ONRAB^® BAITS AS A TACTIC TO CONTROL RABIES IN RACCOONS AND STRIPED SKUNKS IN ONTARIO, CANADA

AERIAL DISTRIBUTION OF ONRAB^® BAITS AS A TACTIC TO CONTROL RABIES IN RACCOONS AND STRIPED SKUNKS IN ONTARIO, CANADA

Chimpanzee-origin adenovirus vectors as vaccine carriers

Pathology and immunogenicity in the cotton rat (Sigmodon hispidus) model after infection with a bovine adenovirus type 3 recombinant virus expressing the firefly luciferase gene

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A Recombinant Human Adenovirus Vaccine against Rabies

Cited by 128 publications

References 14 publications

AERIAL DISTRIBUTION OF ONRAB® BAITS AS A TACTIC TO CONTROL RABIES IN RACCOONS AND STRIPED SKUNKS IN ONTARIO, CANADA

AERIAL DISTRIBUTION OF ONRAB® BAITS AS A TACTIC TO CONTROL RABIES IN RACCOONS AND STRIPED SKUNKS IN ONTARIO, CANADA

Chimpanzee-origin adenovirus vectors as vaccine carriers

Pathology and immunogenicity in the cotton rat (Sigmodon hispidus) model after infection with a bovine adenovirus type 3 recombinant virus expressing the firefly luciferase gene

Contact Info

Product

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AERIAL DISTRIBUTION OF ONRAB^® BAITS AS A TACTIC TO CONTROL RABIES IN RACCOONS AND STRIPED SKUNKS IN ONTARIO, CANADA

AERIAL DISTRIBUTION OF ONRAB^® BAITS AS A TACTIC TO CONTROL RABIES IN RACCOONS AND STRIPED SKUNKS IN ONTARIO, CANADA