A Receptor-Targeted Near-Infrared Fluorescence Probe for In Vivo Tumor Imaging

Tung, Ching‐Hsuan; Lin, Yu‐Ju; Moon, Woo Kyung; Weissleder, Ralph

doi:10.1002/1439-7633(20020802)3:8<784::aid-cbic784>3.0.co;2-x

Cited by 113 publications

(66 citation statements)

References 12 publications

(16 reference statements)

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“…In addition, autofluorescence with visible light below 600 nm is a major background problem that can be edited, however, with new spectral imaging techniques [37]. The major advantage with synthetic near-IR probes is the radiation can potentially penetrate up to 15-20 cm of tissue, although this imaging outcome has yet to be demonstrated in a compelling way [38]. High intensity near-IR fluorescent probes will improve the feasibility of imaging deep tissue locations and will facilitate attempts to improve tomographic 3D reconstruction [39].…”

Section: Methods Comparisonmentioning

confidence: 99%

Optical imaging of bacterial infection models

Leevy¹,

Serazin²,

Smith³

2007

Drug Discovery Today: Disease Models

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Over the last thirteen years, the field of optical imaging has expanded from in vitro fluorescence microscopy of cells to in vivo imaging of living animals. Recent advances in optical imaging of bacterial infection have been propelled by the invention of genetic methods that produce fluorescent and bioluminescent bacteria, and also the discovery of synthetic fluorescent probes that selectively target bacterial cell surfaces. Optical imaging is an effective method of conducting longitudinal studies of bacterial infection in small animals such as nude mice. It can be used to address questions in medical microbiology concerning migration and colonization and it is an attractive method for determining the efficacy of antibiotic therapies.

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Section: Methods Comparisonmentioning

confidence: 99%

Optical imaging of bacterial infection models

Leevy¹,

Serazin²,

Smith³

2007

Drug Discovery Today: Disease Models

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“…A variety of reporter probes have been used for enhanced detection of early cancers, including somatostatin receptor-targeted probes [32][33][34], folate receptor-targeted agents [35], tumor cell-targeted agents [36][37][38][39], agents that incorporate into areas of calcification, bone formation or both [40], and agents being activated by tumor-associated proteases [41][42][43]. Many of these agents accumulate in (and thus enhance) tumors to a certain degree; however, FRET-based agents can yield particularly high tumor/background signal ratios because of their nondetectability in the native state.…”

Section: Detecting Early Cancersmentioning

confidence: 99%

Shedding light onto live molecular targets

Weissleder

Ntziachristos

2003

Nat Med

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1,763

1,319

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Abstract-Optical sensing of specific molecular targets and pathways deep inside living mice has become possible as a result of a number of advances. These include design of biocompatible near-infrared fluorochromes, development of targeted and activatable 'smart' imaging probes, engineered photoproteins and advances in photon migration theory and reconstruction. Together, these advances will provide new tools making it possible to understand more fully the functioning of protein networks, diagnose disease earlier and speed along drug discovery.

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“…These ligands can be regarded as a tumor-specific receptor to construct a "guided molecular missile" with different therapeutic warheads. In an effort to contribute to the development of optical imaging modalities, a variety of fluorescent dyes e.g., fluorescein, Texas Red, the rhodamines, the cyanines (indocyanine green, thiazole orange) [57][58][59], polymethine cyanine dyes (the Cy3, Cy5, Cy5.5, Cy7 series) and the Alexa Fluors have been conjugated to folic acid [60][61][62][63][64]. Nowadays, the development of fluorescent dyes with longer excitation wavelengths (λEx>500 nm) transparent to human tissues [65,66] shows great promise, because imaging of malignant cells by optical means is not hazardous for living organisms [67].…”

Section: Fluorescent Small Molecules As Cell-type-specific Imaging Prmentioning

confidence: 99%

Fluorescent Dyes Used in Polymer Carriers as Imaging Agents in Anticancer Therapy

Miksa¹

2016

Med chem (Los Angeles)

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This review highlights the role of fluorescent dyes as active "molecular photoswiches" focusing on the application in bioimaging and anticancer therapies in the field of therapeutic delivery. The author describes the development of prodrugs targeted to specific cell types and polymeric nanocarriers (capsules, micelles and silica nanoparticles) used as fluorescent probes which offer advantages in the integration of "smart" features of fluorescent dyes into synthetic materials. The incorporation of biologically responsive components that cleave upon changes in pH or light irradiation is fundamental to the successful design of such carriers with capabilities to load and release therapeutics specifically at a target site.

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A Receptor-Targeted Near-Infrared Fluorescence Probe for In Vivo Tumor Imaging

Cited by 113 publications

References 12 publications

Optical imaging of bacterial infection models

Optical imaging of bacterial infection models

Shedding light onto live molecular targets

Fluorescent Dyes Used in Polymer Carriers as Imaging Agents in Anticancer Therapy

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