A recent patent in allergy & immunology: Biomarkers on allergen‐specific memory B cells to predict allergen immunotherapy outcome
Menno C. van Zelm,
Robyn E. O'Hehir,
Craig I. McKenzie
Abstract:Detection of changes in surface protein expression in allergen-specific memory B cells as biomarker for successful immunotherapy. (A) Schematic representation of allergen-specific memory B cells (Bmem). Following AIT, either sublingual (SLIT) for ryegrass pollen or subcutaneous (SCIT) for bee venom, a large fractions of allergen-specific Bmem expressed surface CD23, CD29, IL4Rα and/or IgG4. (B) Example dot plots of Bmem stained with fluorochrome-coupled allergen tetramers for bee venom (Api m 1) or ryegrass po… Show more
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