A Reassessment of the Marrubium Vulgare L. Herb’s Potential Role in Diabetes Mellitus Type 2: First Results Guide the Investigation toward New Horizons

Villanueva, Javier Rodríguez; Alonso‐Esteban, José Ignacio; Villanueva, Laura Salanova

doi:10.3390/medicines4030057

Cited by 14 publications

(13 citation statements)

References 14 publications

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“…Marrubium vulgare has an ethnomedical record as an antidiabetic agent [85,86]. Certain efforts have been made in order to obtain scientific evidence supporting its traditional use in diabetes mellitus control [87]. Hellal et al [88] performed in vitro screening for the α-glucosidase inhibitory activity of six Algerian traditional medicinal plant extracts where M. vulgare 80% ethanol extracts exerted a moderate effect (IC 50 = 12.66 µg/mL).…”

Section: Antidiabetic Activitymentioning

confidence: 99%

Marrubium vulgare L.: A Phytochemical and Pharmacological Overview

et al. 2020

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Marrubium vulgare is a plant with high bioactive potential. It contains marrubiin, a labdane diterpene that is characteristic for this genus, as well as a complex mixture of phenolic compounds. According to numerous studies, M. vulgare acts as a good antioxidant agent, and due to this, it could potentially be useful in treatments of cancer, diabetes mellitus, and liver diseases. In addition, its anti-inflammatory, wound-healing, antihypertensive, hypolipidemic, and sedative potential are discussed. Apart from that, its antimicrobial activity, especially against Gram+ bacteria, fungi, herpes simplex virus, and parasites such as Toxoplasma gondii, Trichomonas vaginalis, and Plasmodium berghei-berghei was recorded. Additionally, it could be used as a chicken lice repellent, herbicide, and natural insecticide against mosquito larvae and natural molluscicide. In veterinary medicine, M. vulgare can be used as an anthelmintic against the eggs and larvae of bovine strongyles parasites, and as an antibiotic against bovine mastitis caused by resistant bacterial strains. Due to the mentioned benefits, there is a tendency for the cultivation of M. vulgare in order to ensure high-quality raw material, but more firm scientific evidence and well-designed clinical trials are necessary for the well-established use of M. vulgare herb and its preparations.

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Section: Antidiabetic Activitymentioning

confidence: 99%

Marrubium vulgare L.: A Phytochemical and Pharmacological Overview

et al. 2020

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“…Once all that work has been completed, and based on the phytopharmaceutical and disease profiles, relevant relationships that can be suitable for clinical application may be identified [36]. Solid principles and promising preclinical results are a helpful starting point for clinical studies to determine the efficacy of a new plant medication [28]. Among them, the integrated metabolomics strategy can be used in pharmacokinetic study of herbal medicines to demonstrate their biological fates, thereby linking the plant metabolome to human metabolome is essential [37].…”

Section: Discussionmentioning

confidence: 99%

“…Marrubium vulgare L. has been selected to exemplify each of the periods represented. Example data obtained from Rodríguez Villanueva[12,28]. COX-2: cyclo-oxigenase-2; PG-E2: prostaglandin-E2; NOS: nitric oxide synthase; 6-ODA: 6-octadecynoic acid.…”

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confidence: 99%

Pharmacological Activities of Phytomedicines: A Challenge Horizon for Rational Knowledge

2018

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Herbal drugs have been widely used throughout the course of history. Traditional knowledge based on religious beliefs and/or experience has been transmitted orally between generations. First attempts to provide scientific evidence came in the 19th century when potent compounds were first isolated. Since then, modern pharmacology theory has been assumed by phytotherapy. Scientists have tried to elucidate the molecular mechanism of each compound and, for a pharmacological indication, propose an effective and secure dose. Stepwise, clinical trials confirm the benefits of herbal drug use in therapeutics, especially for chronic diseases. However, herbal drugs exert pleiotropic effects, and there is still a need for a complete, rational, and widely accepted theory that can explain phytotherapy efficacy. The "-omics" might help with this matter. Studies of modification in the gene expression profile, the metabolome, and the physiopathological state after the administration of a herbal extract could provide relevant information that verifies herbal therapies.

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“…Also, studies were performed using M. vulgare extract, which demonstrated a gastro-protective activity (OLIVEIRA et al, 2011). In addition, its multifunctionality was confirmed through hypoglycemic (VILLANUEVA et al, 2017), vasorelaxant (EL-BARDAI et al, 2004, analgesic (MEYRE-SILVA et al, 2005), anti-inflammatory (EL ABBOUYI et al, 2013), antioxidant (WEEL et al, 1999 and antimicrobial (ZARAI et al, 2011) effect.…”

Section: Introductionmentioning

confidence: 98%

Phytobiotic effect of Marrubium vulgare and Leonurus sibiricus on productive performance of griller-type broilers

et al. 2021

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The food industry is in a continuous search for strategies of reducing of antibiotic residues in livestock production, given the development of antibiotic-resistant bacteria. In that context, there is a consistent increasing in the usage of alternative feed phytogenic additives. Due to the pharmacological, the plants Marrubium vulgare and Leonurus sibiricus, are both potential replacements for growth-promoting antibiotics. This study evaluated the productive performance and analyze the sensory qualities in the meat of broiler that were administered M. vulgare and L. sibiricus infusions. A total of 320 chicks from an poultry farm were distributed in 8 groups groups according treatments by 28 days: Control Group (Saline); Positive control (tylosin 1%, 50 ppm); Groups of M. vulgare (MV) infusion: 2% (MV2), 4% (MV4) and 6% (MV6); and groups treated with L. sibiricus (LS) infusion: 2% (LS2), 4% (LS4) and 6% (LS6), all of them received relative doses corresponding to the live weight percentage in milliliter. There was weght gain in MV6 and LS6 group and a better food conversion in MV4, MV6, LS4, and LS6. In addition, weight gain and enhancement of the pectoral muscles were observed in these groups. The sensory analysis revealed that the broilers’ meat of MV had a more intense flavor. For marketing purposes the meat from birds that received LS had a better demand. Improvement of productive performance and sensory qualities of the broilers meat might be associated with the phytobiotic activity in it. Therefore, MV and LS can be used as natural growth promoter in broilers.

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A Reassessment of the Marrubium Vulgare L. Herb’s Potential Role in Diabetes Mellitus Type 2: First Results Guide the Investigation toward New Horizons

Cited by 14 publications

References 14 publications

Marrubium vulgare L.: A Phytochemical and Pharmacological Overview

Marrubium vulgare L.: A Phytochemical and Pharmacological Overview

Pharmacological Activities of Phytomedicines: A Challenge Horizon for Rational Knowledge

Phytobiotic effect of Marrubium vulgare and Leonurus sibiricus on productive performance of griller-type broilers

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