A reappraisal of the role of polycystic ovary syndrome in recurrent miscarriage

Cocksedge, Karen A; Li, Tin‐Chiu; Saravelos, Sotirios H.; Metwally, Mostafa

doi:10.1016/s1472-6483(10)60304-5

Cited by 68 publications

(46 citation statements)

References 93 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hyperinsulinaemia has been suggested to be a risk factor for miscarriage in PCOS patients (van der Spuy & Dyer 2004, Cocksedge et al 2008) and has been proposed as a main factor in the pathophysiology of early pregnancy loss in PCOS patients (Essah et al 2004). The increased insulin levels reduce synthesis of IGF binding proteins (IGFBPs) such as IGFBP1, which in turn enhances bioactivity of IGF1 (Wang & Chard 1999).…”

Section: Introductionmentioning

confidence: 99%

Increased apoptosis in bovine blastocysts exposed to high levels of IGF1 is not associated with downregulation of the IGF1 receptor

Velazquez¹,

Hermann²,

Kues³

et al. 2011

Reproduction

View full text Add to dashboard Cite

The hypothesis that high concentrations of IGF1 can impair embryo development was investigated in a bovine in vitro model to reflect conditions in polycystic ovary syndrome (PCOS) patients. Embryos were either cultured in the absence or presence of a physiological (100 ng/ml) or supraphysiological (1000 ng/ml) IGF1 concentration. Cell allocation, apoptosis, transcript and protein expression of selected genes involved in apoptosis, glucose metabolism and the IGF system were analysed. Supraphysiological IGF1 concentration did not improve blastocyst formation over controls, but induced higher levels of apoptosis, decreased TP53 protein expression in the trophectoderm and increased the number of cells in the inner cell mass (ICM). The increase in ICM cells corresponded with an increase in IGF1 receptor (IGF1R) protein in the ICM. A small, but significant, percentage of blastocysts displayed a hypertrophic ICM, not observed in controls and virtually absent in embryos treated with physiological concentrations of IGF1. Physiological IGF1 concentrations increased total IGF1R protein expression and upregulated IGFBP3 transcripts leading to an increase in blastocyst formation with no effects on cell number or apoptosis. In conclusion, the results support the hypothesis of detrimental effects of supraphysiological IGF1 concentrations on early pregnancy. However, our results do not support the premise that increased apoptosis associated with high levels of IGF1 is mediated via downregulation of the IGF1R as previously found in preimplantation mouse embryos. This in vitro system with the bovine preimplantation embryo reflects critical features of fertility in PCOS patients and could thus serve as a useful model for in-depth mechanistic studies.

show abstract

Section: Introductionmentioning

confidence: 99%

Increased apoptosis in bovine blastocysts exposed to high levels of IGF1 is not associated with downregulation of the IGF1 receptor

Velazquez¹,

Hermann²,

Kues³

et al. 2011

Reproduction

View full text Add to dashboard Cite

show abstract

“…It was asserted in some studies that PCOS and high LH levels play a role. The rate of PCOS identification in cases with recurrent abortion was reported as between 0% and 56% in different studies [2][3][4]. In our series composed of 57 patients, the rate of cases with BMI ≥ 25 was 49.1%.…”

Section: Discussionmentioning

confidence: 51%

“…The average age was 30.60±6.23. Gravida average of the cases was 3.98±1.40 (3)(4)(5)(6)(7)(8) and the parity average was 0.48±0.91 (0-4). While 53 cases had normal menstrual cycles (25-35 days), 4 cases had oligomenorrhoea.…”

Section: Resultsmentioning

confidence: 96%

The Role of Endocrine and Endometrial Factors in Cases of Recurrent Miscarriage: A Tertiary Center Experience

Uysal¹,

Taner²,

Mun³

et al. 2015

Ann Clin Anal Med

View full text Add to dashboard Cite

“…There is conflicting data on PCOS and miscarriages 26,28 and no strong evidence that PCOS per se increases rates of miscarriage. 26,28 However, women with PCOS are often overweight or obese; this increases their risk of miscarriage and pregnancy loss.…”

Section: Miscarriagesmentioning

confidence: 99%

“…26,28 However, women with PCOS are often overweight or obese; this increases their risk of miscarriage and pregnancy loss. 29 Pregnancy Pregnant women who are diagnosed with PCOS are at risk of developing gestational diabetes, 26,30,31 preeclampsia, 26,31 and cardiovascular disease, 31 which are all associated with poorer pregnancy outcomes.…”

Section: Miscarriagesmentioning

confidence: 99%

Identification and management of conditions detrimental to IVF outcome

Szmelskyj

2015

Acupuncture for IVF and Assisted Reproduction

View full text Add to dashboard Cite

A reappraisal of the role of polycystic ovary syndrome in recurrent miscarriage

Cited by 68 publications

References 93 publications

Increased apoptosis in bovine blastocysts exposed to high levels of IGF1 is not associated with downregulation of the IGF1 receptor

Increased apoptosis in bovine blastocysts exposed to high levels of IGF1 is not associated with downregulation of the IGF1 receptor

The Role of Endocrine and Endometrial Factors in Cases of Recurrent Miscarriage: A Tertiary Center Experience

Identification and management of conditions detrimental to IVF outcome

Contact Info

Product

Resources

About