A reappraisal of the nature and significance of chronic atrophic gastritis

Strickland, R. G.; Mackay, Ian R.

doi:10.1007/bf01071995

Cited by 503 publications

(193 citation statements)

References 89 publications

Supporting

Mentioning

173

Contrasting

Unclassified

Order By: Relevance

“…In this regard, TNF has been shown to mediate the mucosal lesion in graftvs.-host disease (53) and the inflammation and ulceration in cytomegalovirus colitis (S. S. Saini and P. D. Smith, manuscript submitted). Similarly, local TNF production may contribute to the pathogenesis of benign gastric ulcer which has been associated with chronic gastritis (54)(55)(56) and the presence of H. pylori in the antrum (4). In this regard, the recent observation by Crabtree et al (57) that cultures of gastric mucosal biopsies from H. pylori-infected persons release significantly greater amounts of TNFa into culture supernatants than do biopsies from uninfected control subjects supports our observations.…”

Section: Discussionsupporting

confidence: 79%

Soluble surface proteins from Helicobacter pylori activate monocytes/macrophages by lipopolysaccharide-independent mechanism.

E¹,

Perez-Perez²,

Wahl³

et al. 1991

J. Clin. Invest.

279

146

View full text Add to dashboard Cite

These findings indicate that H. pylori is capable of activating human monocytes by an LPS-independent as well as an LPS-dependent mechanism. H. pylori activation of resident lamina propria macrophages and monocytes trafficking through the mucosa, leading to the secretion of increased amounts of inflammatory cytokines and reactive oxygen intermediates, could play an important role in mediating the inflammatory response associated with H. pylori gastritis and duodenitis. (J. Clin. Invest. 1991. 87:894-900.)

show abstract

Section: Discussionsupporting

confidence: 79%

Soluble surface proteins from Helicobacter pylori activate monocytes/macrophages by lipopolysaccharide-independent mechanism.

E¹,

Perez-Perez²,

Wahl³

et al. 1991

J. Clin. Invest.

279

146

View full text Add to dashboard Cite

show abstract

“…called pernicious anaemia. Strickland & Mackay [26], in classifying atrophic gastritis and assigning pernicious anaemia to type A gastritis, placed great emphasis on the anti-parietal cell antibody in this classification. The changed pattern observed here, in particular the diminished prevalence of anti-parietal cell antibody, raises the possibility that the nature of the atrophic gastritis or its immunologic manifestations may be different.…”

Section: Discussionmentioning

confidence: 99%

Reassessment of the relative prevalences of antibodies to gastric parietal cell and to intrinsic factor in patients with pernicious anaemia: influence of patient age and race

Carmel

1992

Clinical and Experimental Immunology

103

View full text Add to dashboard Cite

SUMMARYAnti-parietal cell antibody has been reported in nearly all patients with pernicious anaemia in past studies, in contrast with anti-intrinsic factor (IF) antibody which occurs in only 50-70% of such patients. However, observations in the more diverse patient population at our hospital suggest that these prevalences, originally described in predominantly elderly, white patients of European origin, no longer apply. Anti-IF antibody was found in 70% ofthe 324 patients, with blacks (84%) and Latin Americans (69%) having a significantly higher prevalence than whites (55%). In contrast, only 55% of the 266 patients tested had anti-parietal cell antibody. It was noteworthy that this low rate was similar in all racial groups. However, patients lacking anti-parietal cell antibody were significantly younger than those who had the antibody (54-8+ 17-8 vs 59 6± 16 2 years, P = 0 022). Overall, a striking 30% of all patients had anti-IF antibody but not anti-parietal cell antibody, while only 13% had the latter antibody without having anti-IF antibody. This pattern was particularly striking among black patients. An interesting incidental observation was that gastrin levels were not associated with antibody status, but were significantly higher not only among women than among men but also among white and black patients than among Latin-American patients. The findings show that anti-parietal cell antibody is not found nearly as often in pernicious anaemia as has been reported in the past, and thus has no value as a diagnostic tool in pernicious anaemia. They also suggest clues to different expressions of pernicious anaemia or of its immunologic response, particularly among younger patients with the disease.

show abstract

“…Type A gastritis is associated with an autoimmune disease and involves mainly the fundus and body of the stomach [1]. It is generally seen in elderly patients, in whom severe atrophy of the mucosa develops.…”

Section: Introductionmentioning

confidence: 99%

Long-term follow up of patients with multiple gastric carcinoids associated with type A gastritis

et al. 2005

View full text Add to dashboard Cite

Little is known about the natural course of multiple gastric carcinoids associated with type A gastritis. Between 1993 and 2003, we enrolled eight patients, diagnosed as having multiple gastric carcinoids associated with type A gastritis, in a followup program without surgical resection. In these patients, endoscopy showed multiple small polyps on the gastric body, with nonantral atrophic gastritis. Histologically, biopsy specimens obtained from the polyps revealed carcinoid tumors. The serum gastrin level was found to be very high in all patients, and testing for anti-parietal cell antibody was positive in seven. The mean follow-up was 5.8 years (range, 1.5-10.8 years). The levels of serum gastrin increased in all patients, but, endoscopically, the carcinoid tumors did not change in size. Neither hepatic nor lymphatic metastasis was detected on abdominal computed tomography (CT). These patients were free of the development or metastasis of carcinoids, in spite of their continuous hypergastrinemia. It was concluded that multiple gastric carcinoids associated with type A gastritis may be indolent.

show abstract

A reappraisal of the nature and significance of chronic atrophic gastritis

Cited by 503 publications

References 89 publications

Soluble surface proteins from Helicobacter pylori activate monocytes/macrophages by lipopolysaccharide-independent mechanism.

Soluble surface proteins from Helicobacter pylori activate monocytes/macrophages by lipopolysaccharide-independent mechanism.

Reassessment of the relative prevalences of antibodies to gastric parietal cell and to intrinsic factor in patients with pernicious anaemia: influence of patient age and race

Long-term follow up of patients with multiple gastric carcinoids associated with type A gastritis

Contact Info

Product

Resources

About