A Reappraisal of the Incidence of Placental Hydatidiform Mole Using Selective Molecular Genotyping

Abstract

Our observed incidence of HM is greater than previous studies and is attributable to improved detection of PM cases. Molecular genotyping and cytogenetic evidence indicate that CM is almost half as common as PM. This ratio may be useful in benchmarking laboratory diagnosis and HM registries.

LiFE | Literature for ENYGO

“…Four of them are focused on Lynch syndrome (LS) [7][8][9][10] A new hysteroscopic scoring system for a differential diagnosis between EH and cancer was suggested by to by Ianieri et al. It resulted in a good diagnostic performance, especially for less experienced surgeons.…”

“…After resection of an atypical endometrial polyp, the risk of endometrial cancer was estimated to be 5.6 %. [10] This is important in the context of patients' follow-up and further treatment.…”

“…[7][8][9] endometrial cancer A randomised controlled trial in 101 patients comparing robotic versus traditional laparoscopic surgery demonstrates that, in a well-trained team, robotic surgery was shorter and had fewer conversions to laparotomy than laparoscopy, with no differences in the number of lymph nodes removed, bleeding, or the length of postoperative hospital stay. [10] The robotic approach seems to have similar 30-day costs than open staging, based upon its lower postoperative complications, shorter median length of stay, and lower readmission rate. [11] The increased risk of positive cytology during laparoscopic surgery for uterine cancer using a uterine manipulator is a major issue of concern, and two papers have reassured the fact that this risk is not increased based on retrospective single institution data.…”

“…Davidson et al presented the analysis of oestrogen (ER) and progesterone receptors (PR) in early LMS (294 FIGO stage I patients) and concluded that PR expression is related with longer patient overall survival (P = .042) [10]. Garcia et al, in their molecular analysis, proposed the sonic hedgehog proteins be used as markers in differentiation between various myometrial lesions [11].…”

“…This includes cascade testing among the at-risk relatives of those diagnosed with LS. Djordjevic et al review the main tissue testing modalities for LS in the pathology laboratory, such as immunohistochemistry and PCRbased analyses and discusses their routine application [10]. The National Comprehensive Cancer Network has published its clinical practice guidelines in genetic high-risk assessment for colorectal cancer (CR).…”