A Reappraisal of Some Skeletal Changes in Currently Treated β-Thalassemia

Scutellari, P N; Franceschini, F; Orzincolo, C

doi:10.1007/978-3-642-72587-6_6

Cited by 2 publications

(1 citation statement)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The variations observed in the current study may have been caused by the duration, frequency, and regimen of blood transfusions in each patient. Notably, 55% of patients with thalassemia who received adequate transfusions did not develop facial bone deformities, 12 indicating that adequate treatment can prevent such deformities.…”

Section: Discussionmentioning

confidence: 99%

Lateral facial profile of β-thalassemia major in Javanese children: a photogrammetric analysis

Parengkuan,

Kuswandari,

Soeprihati

2023

Med J Indones

View full text Add to dashboard Cite

BACKGROUND Impairment of globin chain synthesis in patients with β-thalassemia major causes ineffective erythropoiesis. This condition triggers bone marrow hyperplasia and can lead to craniofacial bone abnormalities. This study aimed to evaluate the lateral facial profile of β-thalassemia major, identify any differences when compared with a control group of similar age and ethnicity, and reveal the facial profile of β-thalassemia major in Javanese children. METHODS This cross-sectional study included 35 β-thalassemia major children aged 7–15 years. They were divided into 3 groups based on their age. Lateral facial photogrammetry was taken by measuring the forehead protrusion and nasolabial angle. Data were then mapped to the normal group of children in the same age group and descriptively analyzed using SPSS software. RESULTS The 1 and 2 SD group had a higher prevalence of β-thalassemia major in children aged 7–9 years for both sexes. The older age group had a closer mean value to those of children without thalassemia. CONCLUSIONS The forehead and maxillary profile of Javanese β-thalassemia major children tended to be protrusive, especially in the 7–9 years age group, while the older age groups had closer mean values to those of children without thalassemia.

show abstract

Section: Discussionmentioning

confidence: 99%

Lateral facial profile of β-thalassemia major in Javanese children: a photogrammetric analysis

Parengkuan,

Kuswandari,

Soeprihati

2023

Med J Indones

View full text Add to dashboard Cite

show abstract

Forager and farmer evolutionary adaptations to malaria evidenced by 7000 years of thalassemia in Southeast Asia

Vlok

Buckley

Miszkiewicz

et al. 2021

Sci Rep

View full text Add to dashboard Cite

Thalassemias are inherited blood disorders that are found in high prevalences in the Mediterranean, Southeast Asia and the Pacific. These diseases provide varying levels of resistance to malaria and are proposed to have emerged as an adaptive response to malaria in these regions. The transition to agriculture in the Holocene has been suggested to have influenced the selection for thalassemia in the Mediterranean as land clearance for farming encouraged interaction between Anopheles mosquitos, the vectors for malaria, and human groups. Here we document macroscopic and microscopic skeletal evidence for the presence of thalassemia in both hunter-gatherer (Con Co Ngua) and early agricultural (Man Bac) populations in northern Vietnam. Firstly, our findings demonstrate that thalassemia emerged prior to the transition to agriculture in Mainland Southeast Asia, from at least the early seventh millennium BP, contradicting a long-held assumption that agriculture was the main driver for an increase in malaria in Southeast Asia. Secondly, we describe evidence for significant malarial burden in the region during early agriculture. We argue that the introduction of farming into the region was not the initial driver of the selection for thalassemia, as it may have been in other regions of the world.

show abstract

A Reappraisal of Some Skeletal Changes in Currently Treated β-Thalassemia

Cited by 2 publications

References 41 publications

Lateral facial profile of β-thalassemia major in Javanese children: a photogrammetric analysis

Lateral facial profile of β-thalassemia major in Javanese children: a photogrammetric analysis

Forager and farmer evolutionary adaptations to malaria evidenced by 7000 years of thalassemia in Southeast Asia

Contact Info

Product

Resources

About