A real-world study of camrelizumab in the treatment of advanced lung cancer patients.

Abstract

e21056 Background: Camrelizumab, as a humanized antibody against PD-1, has shown high efficiency and survival benefits in clinical studies on lung cancer treatment. This study aims to observe the efficacy and safety of Camrelizumab in the treatment of advanced lung cancer in the real world. Methods: This is a prospective, open, multi-center observational study that includes patients with advanced lung cancer who are older than 18 years of age, regardless of gender, with an ECOG score of 0-2. Results: As of November 18, 2020, a total of 253 patients have been enrolled. Males accounted for 187 cases (74.2%). The ECOG PS score was 0 in 44 cases (17.3%), 1 in 162 cases (64.0%), and 2 in 47 cases (18.6%). There were 181 patients (71.5%) of stage IV, 96 patients (37.9%) of adenocarcinoma, and 98% of patients did not undergo PD-L1 testing. A history of radiotherapy accounted for 31.2%, and a history of surgery on the primary lesion accounted for 20.2%. Camrelizumab accounted for 29.6% of the first-line treatment, 27.2% of the second-line treatment, and 43.1% of the third-line and above. Camrelizumab monotherapy accounted for 20.1%, camrelizumab combined with chemotherapy accounted for 56.3%, combined anti-angiogenesis therapy accounted for 22.1%, and combined anti-angiogenesis + chemotherapy accounted for 1.5%. Among the 199 patients with evaluable efficacy, 4 were CR, 46 were PR, 116 were SD, and 33 were PD. The ORR reached 25.1% and the DCR reached 83.4%. The overall adverse event rate was 33.7%, the major adverse event RCCEP rate was 22.6%, appetite loss was 5%, and fatigue was 3.5%. There were 4 cases (2%) of RCCEP with adverse events greater than or equal to grade 3. Conclusions: In this real-world study of lung cancer, most of the patients enrolled were patients with poor PS score and late stage, but the efficacy and safety of camrelizumab in patients with advanced lung cancer were still confirmed. The dominant population and combination therapy are still under study. Clinical trial information: ChiCTR2000034595.

Effectiveness and safety of camrelizumab in inoperable or advanced non-small cell lung cancer patients: a multicenter real-world retrospective observational study (CTONG2004-ADV)

“…However, it was higher than the results reported periodically in the two prospective observational studies (25% and 26%) (11,12). Interestingly, despite the comparatively lower ORR observed in real-world settings, the DCR (85.1%) was generally comparable among the pivotal trials (CameL: 87.8% for non-squamous NSCLC; CameL-sq: 88.1% for squamous NSCLC) (7,8) and observational studies (83.40% and 89.30%) (11,12). These variations may be partially explained by different patient characteristics and treatment variables.…”

“…The ORR (40.2%) observed in our cohort was lower than observed in firstline trials (CameL: 60.5% for non-squamous NSCLC; CameL-sq: 64.8% for squamous NSCLC) (7,8). However, it was higher than the results reported periodically in the two prospective observational studies (25% and 26%) (11,12). Interestingly, despite the comparatively lower ORR observed in real-world settings, the DCR (85.1%) was generally comparable among the pivotal trials (CameL: 87.8% for non-squamous NSCLC; CameL-sq: 88.1% for squamous NSCLC) (7,8) and observational studies (83.40% and 89.30%) (11,12).…”