The arrangement optimization algorithm of blades can reduce the vibration localization of mistuned bladed disk in a compressor of aero-engine, however, it will destroy the dynamic balance of bladed disk. A new arrangement optimization method of isolation zone on bladed disk system considering unbalance moment is proposed, on the basis the reduced order modeling technology. This method is based on the finite element model and can be implemented as fast and accurate vibration reduction optimization without destroying the mass balance of the bladed disk system, the method considers both mass and stiffness mistuning. Firstly, the discrete particle swarm optimization algorithm is used to sort the mass-mistuned blades according to unbalanced moment, then, the arranged bladed disk is divided into 6 isolation zones, then, in each isolation zone, the stiffness mistuned bladed disk is arranged optimally by the stiffness mistuning optimization algorithm. Under the premise of satisfying the dynamic balance of bladed disk, this algorithm optimizes the arrangement of blades with mass mistuning and stiffness mistuning, and achieves the purpose of vibration reduction optimization of mistuned bladed disk. The results show that, the maximum amplitude of the bladed disk system is reduced by 23.9 %. The vibration localization degree of the optimized blade are reduced by 46.3 %.