A Re-examination of certain aspects of the histogenesis of the healing of cutaneous wounds A preliminary report

Gillman, Theodore; Penn, Jack; Bronks, Doris; Roux, Marie; Bilbrough, Phyllis; Low, Patricia R.; Hart, Adele

doi:10.1002/bjs.18004317804

Cited by 73 publications

(16 citation statements)

References 12 publications

(4 reference statements)

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“…Advances in anaesthesia and surgery have not been parallelled by advances in wound care, which is an integral part of any surgical procedure. The method of skin closure generally used in surgery is with sutures which provide an extra source of contamination and are a potential source of foreign body reaction in the susceptible subcutaneous tissue [1]. This increases the complication rate besides being time consuming during application.…”

mentioning

confidence: 99%

Sutureless closure of Operative Skin Wounds

Nagpal

Kumar

Nagi

et al. 2004

Medical Journal Armed Forces India

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Good tissue union and cosmetically acceptable scar is vital for ideal surgical practice. Since their discovery in 1949, cyanoacrylate compounds have evoked interest as being the ideal "tissue glue". Several different forms of this compound have been developed in order to eliminate tissue toxicity. In this article, we have described a technique of sutureless closure of operative skin wounds and compared it to closure of skin with silk. Inter-group comparison was carried out with respect to the time required for closure, rate of infection, cosmesis and patient acceptance. N-butyl 2-cyanoacrylate was used for sutureless skin closure in 100 patients and compared with skin closure with sutures. The time taken to close the wounds with cyanoacrylate was found to be significantly less, the cosmetic outcome better and patient acceptability higher than when sutures were used.

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confidence: 99%

Sutureless closure of Operative Skin Wounds

Nagpal

Kumar

Nagi

et al. 2004

Medical Journal Armed Forces India

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“…The dynamics of epidermal wound healing can be divided for the purpose of understanding into three phases: (1) epithelial migration, (2) cell division, and (3) differentiation.…”

mentioning

confidence: 99%

Local Wound Environment and Epidermal Healing

Rovee¹

1972

Arch Dermatol

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“…All this means that in restored skin the internal media is closed within about a week, a fact that occurs in ulcers only after the completion of healing. In this healing process there is the formation of typical granulation tissue, while in restored skin it is young conjunctive tissue that forms, which is different from granulation tissue (22). In restored skin the hair follicles and the sebaceous and sudoriparous glands are preserved in varying degrees, whereas this does not happen in scars.…”

Section: Discussionmentioning

confidence: 98%

“…Second-degree burns and healed split skingraft donor sites show no clinically perceptible contraction (22,23), which seems to argue for a lack of myofibroblasts in these teguments. Reviewing reports, however, we found no proof of this hypothesis, so the question of whether myofibroblasts exist where there is no contraction was still open.…”

mentioning

confidence: 96%

Contraction and Myofibroblasts in Restored Skin

Gómez

Mariani

Pinto

et al. 1998

Scandinavian Journal of Plastic and Reconstructive Surgery and

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Myofibroblasts and the contraction of split skin-graft donor sites were studied in 18 patients. For each patient five samples were studied, taken on days 0, 14, 21, 28, and 35. On each occasion the extensions and densities of myofibroblasts were calculated. After the initial measurement, the subsequent extensions were expressed in percentages of the first, resulting in mean measurements of 100, 95, 97, 99, and 99%, respectively. The myofibroblasts in 10 dermic fields were counted under light microscopy at a magnification of 1000 marked with anti-alpha-smooth muscle actin antibodies using immunoperoxidase, resulting in the means of 0.2, 3.8, 1.3, 1.3, and 0.4, respectively. The contraction and the increase in density of myofibroblasts were transitory and significant in the samples measured on day 14, but in sample 35 neither of the variables was significantly different from the initial sample. These variables evolved concurrently, corroborating the hypothesis that myofibroblasts are responsible for the contraction.

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A Re-examination of certain aspects of the histogenesis of the healing of cutaneous wounds A preliminary report

Cited by 73 publications

References 12 publications

Sutureless closure of Operative Skin Wounds

Sutureless closure of Operative Skin Wounds

Local Wound Environment and Epidermal Healing

Contraction and Myofibroblasts in Restored Skin

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