A Re-Evaluation of the Calorigenic Action of the L- And D-Isomers of Thyroxine

Tabachnick, I. I. A.; Parker, R. E.; Wagner, J. W.; Anthony, Paul Z.

doi:10.1210/endo-59-2-153

Cited by 11 publications

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“…Ham- olsky et aZ (2) have reported that reproducible results were obtained with non-sterile human blood stored in a refrigerator for 7 days and with sterile blood kept under refrigeration for as long as 32 days. Ham- olsky et aZ (2) have reported that reproducible results were obtained with non-sterile human blood stored in a refrigerator for 7 days and with sterile blood kept under refrigeration for as long as 32 days.…”

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confidence: 95%

“…This procedure has been shown to possess diagnostic accuracy in humans comparable to other standard tests such as: a) basal metabolic rate, b) chemical protein bound iodine, and c ) thyroid II3l uptake (2)(3)(4)(5). This procedure has been shown to possess diagnostic accuracy in humans comparable to other standard tests such as: a) basal metabolic rate, b) chemical protein bound iodine, and c ) thyroid II3l uptake (2)(3)(4)(5).…”

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confidence: 98%

“…It has been reported that RBC uptake of T3-I131 depends upon thyroid hormone-plasma protein interactions and indirectly measures the ability of the plasma to bind T3-I131 ( 2 ) . It has been reported that RBC uptake of T3-I131 depends upon thyroid hormone-plasma protein interactions and indirectly measures the ability of the plasma to bind T3-I131 ( 2 ) .…”

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confidence: 99%

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Variables Influencing Uptake of Radioactive Triiodothyronine from Plasma by Erythroeytes of Cattle.

Szabó¹,

Mixner²

1964

Experimental Biology and Medicine

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1ectomized chicks indicate that the D-isomer has a similar action on cholesterol synthesis and turnover as does L-thyroxine.SummaTy. The effect of Land D-thyroxine on cholesterol synthesis and turnover in thyroidectomized and in normal untreated chicks has been compared using a~e t a t e -2 -C~~ and cholesterol-4-CI4. (a). Although liver weights and liver cholesterol levels were not significantly different between the normal (EU) and iodoamino acid treated thyroidectomized chicks and those thyroidectomized without treatment, serum cholesterol levels were elevated only in the last group. (b). Appearance of labeled serum cholesterol after a~e t a t e -2 -C~~ injection, cholesterol synthesis after incubation of liver slices with acetate-2-CI4, and cholesterol-4-CI4 turnover in these various groups indicate that both L-thyroxine and D-thyroxine in the quantities used can stimulgte cholesterol biosynthesis and turnover in a manner comparable to that found in the normal. (c). The data are discussed in the light of present concepts of the mode of action of thyroid substances on cholesterol metabolism, and the applicability of the findings to mammalian species.The authors are indebted to Dr.

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Variables Influencing Uptake of Radioactive Triiodothyronine from Plasma by Erythroeytes of Cattle.

Szabó¹,

Mixner²

1964

Experimental Biology and Medicine

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“…In recent years the calorigenic (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16) and antigoitrogenic (2)(3)(4)(5)(6)(7)(8)(9)(17)(18)(19)(20) procedures have been used extensively, and the relative effectiveness of various analogs in lowering blood cholesterol has also been determined (5)(6)(7)(8)(9)(17)(18)(19)(20)(21). The suppression of iodine uptake by the rat thyroid (22) and the increase in heart weight (9) and heart rate (16) have also been used as assay procedures.…”

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New Assay Procedure for Thyroxine Analogs

1965

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The large increase in rat liver and kidney a-glycerophosphate dehydrogenase activity (GPD) which results from the administration of thyroxine (T 4 ) has been developed into a simple assay procedure for thyromimetic substances. The dose-response curves obtained with T 4 and other analogs were analyzed by 2 variations of the usual semilog plot as well as by a new hemisigmoid procedure. The results agreed well with previously reported calorigenic activities. Both weanling and adult rats produced endogenously the equivalent of about 1 /ig T 4 /100 g body wt /day, but the adults were appreciably less sensitive to the hormone. The nature of the < diet fed to rats during the assay period modified the response even when the T 4 was administered subcutaneously; approximately 3 times as much T 4 was required to produce a given * response on a chow diet as on a purified diet. (Endocrinology 77: 802, 1965)

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Comparative Clinical and Biochemical Effects of the Dextro- and Levo- Isomers of Thyroxine

Starr¹

1958

Arch Intern Med

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The clinical and physiological comparisons of the isomers of thyroxine by a number of investigators are well summarized by Ta- by sodium D-thyroxine given in various amounts by oral daily dosage. Groups of normal medical students with radio¬ active-iodine uptake measurements of about 20% in 24 hours were given a placebo, a capsule of potassium iodide, sodium L-thyroxine, or sodium D-thyroxine, once daily by mouth for eight days.Twenty-four-hour radioactive-iodine uptake was measured before these medications were initiated and on the seventh and eighth days during the administration of these medications. The compari¬ son of the effect on depression of the radioactive iodine uptake is tabulated below ( Table 7). The brief history of an athyreotic patient is given below with accompanying chart (Fig. 1)

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A Re-Evaluation of the Calorigenic Action of the L- And D-Isomers of Thyroxine

Cited by 11 publications

References 0 publications

Variables Influencing Uptake of Radioactive Triiodothyronine from Plasma by Erythroeytes of Cattle.

Variables Influencing Uptake of Radioactive Triiodothyronine from Plasma by Erythroeytes of Cattle.

New Assay Procedure for Thyroxine Analogs

Comparative Clinical and Biochemical Effects of the Dextro- and Levo- Isomers of Thyroxine

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