The swelling pressure of bentonite changes dramatically due to diffused nuclear radiation heat and underground osmosis, causing the failure of the buffer isolation layer in deep geological repositories for the disposal of high-level radioactive waste. A detailed overview of the relevant research results on the swelling pressure variation of bentonite under thermo-chemical effects is presented in this paper. The results showed that the values of the swelling pressure obtained by different test methods are dissimilar. The swelling pressure of bentonite decreased with the increasing pore solution concentration; nevertheless, the effect of temperature on the swelling pressure is still controversial. At the micro-level, crystal layer swelling and double- layer swelling are generally considered to be the main factors affecting the swelling pressure; the pore structure and water distribution of bentonite will change owing to thermo-chemical effects. At the macro-level, involving intergranular stress, a mechanical parameter was proposed to explain the mechanism of the changes in the swelling pressure of bentonite. Finally, future research directions for the study of the evolution of bentonite swelling properties under thermo-chemical effects are proposed, based on the current research results.