A rational approach towards the design of chitosan-based nanoparticles obtained by ionotropic gelation

Kleine-Brueggeney, H.; Zorzi, Giovanni K.; Fecker, T.; Gueddari, Nour Eddine El; Moerschbacher, Bruno M.; Goycoolea, Francisco M.

doi:10.1016/j.colsurfb.2015.07.016

Cited by 34 publications

(35 citation statements)

References 42 publications

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“…In an ongoing study, we are addressing the role of the degree of acetylation, molecular weight and concentration of chitosan, and the ionic strength of the solvent, on the particle size of chitosan–tripolyphosphate nanoparticles. [34b] The increase in production yield observed for the CSs of very high DA in the present study is consistent with the proposal that the net electrostatic cross‐linking of −NH 3 + is not the only mechanism that governs the behavior of these systems, but cooperative effects must also contribute to their overall cross‐linking. The disruption of the formation of cooperative junction zones involving locally ordered polymer stretches of neighboring glucosamine residues cross‐linked by TPP ions, may account for the gradual reduction in the yield of nanoparticles formed.…”

Section: Resultssupporting

confidence: 91%

“…In agreement with this suggestion, if we consider that at a fixed mass ratio of CS to TPP, there is an increase in GlcNAc residues (which occurs at the expense of GlcN ones during N‐acetylation), it means that the net charge ratio of −NH 3 + to phosphate groups decreases. In a related study,[34a] we have shown that the dependence of the physical characteristics and yield of formation of nanoparticles on the molar ratio of −NH 3 + to TPP is highly influenced by CS's DA and does not describe a unique trend of behavior. The results of the present study are consistent with those of our previous study in which as the DA increases (up to 47%), the yield of nanoparticle production decreases.…”

Section: Resultsmentioning

confidence: 97%

“…The decrease in ζ of nanoparticles of LDP and HDP CS of the highest DA may reflect that a different structural rearrangement takes place in these nanoparticles as they are unable to accommodate all the hydrophobic, neutral groups inward. Interestingly, when the nanoparticles are produced in NaCl 85 × 10 −3 m , and the stoichiometry of amino functions to TPP (NH 3 + /TPP molar ratio) is fixed,[34a] the influence of the DA on the size of CS–TPP NPs is very different. In this case, the particle size of nanoparticles comprising high DA CS is smaller than those comprising the polymer of lower DA.…”

Section: Resultsmentioning

confidence: 99%

“…To some extent, this is because each study is performed with chitosans from different characteristics (e.g., DA, M w , origin, purity), and they each use different preparation protocols. In related studies, we have addressed the role of the physicochemical variables involved in the formation of CS–TPP nanoparticles for CS of varying DA and M w . The present study aims to shed light on the role of the structural characteristics of CS (DA and M w ) on the physical properties and the colloidal stability in different biologically relevant environments of CS‐based nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

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Physical Properties and Stability of Soft Gelled Chitosan‐Based Nanoparticles

Goycoolea

Brunel

Gueddari

et al. 2016

Macromolecular Bioscience

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We addressed the role of the degree of acetylation (DA) and of M of chitosan (CS) on the physical characteristics and stability of soft nanoparticles obtained through either ionic cross-linking with sodium tripolyphosphate (TPP), or reverse emulsion/gelation. Each of these methods affords nanoparticles (NPs) or nanogels (NGs), respectively. The size of CS-TPP NPs comprising CS of high M (≈123-266 kDa) increases with DA (≈1.6%-56%), while it do not change for CS of low M (≈11-13 kDa); the zeta potential (ζ) decreases with DA regardless of M (ζ ≈+34.6 ± 2.6 to ≈+25.2 + 0.6 mV) and the NPs appear as spheres in transmission electron microscopy. Stability in various cell culture media (pH 7.4 at 37 °C) is greater for NPs made with CS of DA ≥ 27%. In turn, NGs exhibit larger sizes (520 ± 32 to 682 ± 27 nm) than do CS-TPP NPs, and can only be formed with CS of DA < 30%. The average diameter size for these NGs shows a monotonic increase with CS's M . The physical properties and stability of these systems in biological media depend mostly on the DA of CS and its influence on the balance between hydrophilic/hydrophobic interactions.

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Section: Resultssupporting

confidence: 91%

Section: Resultsmentioning

confidence: 97%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Physical Properties and Stability of Soft Gelled Chitosan‐Based Nanoparticles

Goycoolea

Brunel

Gueddari

et al. 2016

Macromolecular Bioscience

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“…It may be simple, attractive and advantageous method that can be fully industrialized. From sustained recent development many workers reported rational characterization with impact on the pharmaceutical properties of systems prepared according to this method [24][25][26] or new applications such as fibbers like materials [27] or an onion-like multimembrane hydrogel structure fabricated via a multistep interrupted gelation that was able to control the release of both hydrophobic and hydrophilic model drugs [28] .…”

mentioning

confidence: 99%

Preparation and Characterization of Cross-Linked Chitosan Microcapsules for Controlled Delivery of Oxytetracycline

Larbi-Bouamrane¹,

Bal²,

Aliouche³

et al. 2016

pharmaceutical-sciences

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Larbi-Bouamrane, et al.: Preparation of Chitosan Microcapsules for Delivery of OxytetracyclineFormulations of encapsulated oxytetracycline in chitosan spherical beads have been developed in this work through the ionotropic gelation method in sodium tripolyphosphate or hexametaphosphate and characterized as drug delivery system to the gastrointestinal tract by Fourier transform infrared spectroscopy, thermal analysis and in vitro drug release in simulated gastric fluids. The Fourier transform infrared spectroscopy and differential scanning calorimetry measurements showed that tripolyphosphate and hexametaphosphate are cross-linked ionically to chitosan and there was no significant drug interaction between the entrapped drug and the carrying polymer. With respect to chitosan cross-linking features, sodium hexametaphosphate seems to give better swelling, higher diffusion and faster release kinetics, while addition of glutaraldehyde as a second cross-linking agent lowers the drug discharge. Release extent and kinetics were found to be pH dependent and approximated very well by the multistep models equations of Makoid-Banakar, PeppasSahlin and Korsmeyer-Peppas. Key words: Oxyteracycline, chitosan, encapsulation, crosslinking, release kineticsTetracyclines are broad spectrum antibiotics that exhibit activity against a wide range of Gram-positive and Gram-negative bacteria. Their favourable antimicrobial properties and the absence of major adverse effects have led to their extensive use in the therapy of human and animal infections [1][2][3][4] . Unfortunately, like the other antibiotic and as a result of the extensive prescription in conventional formulations, the emergence of microbial resistance has limited their effectiveness. So, other strategies are needed to keep tetracycline's and other antibiotics as resources for the next generation and to restore their initial antimicrobial activity. These strategies are based on the development of new classes of drugs with unique antibacterial mechanisms or new formulations enabling the reduction of amounts of antimicrobials used worldwide. In particular, investigation of new formulations has been carried out in order to overcome the disadvantages resulting from the administration of antibiotics in conventional forms [5][6][7] .The specific addressing of active molecules to the organ, tissue or cell is considered now as a major challenge and promising route for the treatment of various human diseases, including bacterial infections, cancer or genetic diseases [8] . New carrying and targeting approaches for drug delivery have been extensively studied in recent years. Most of them are centered on the development of nano-or micro-scale carrying systems [9][10][11] or specific molecules to improve and maximize drug bioavailability and hence therapeutic effects over a period of time. This highly selective approach would ensure an optimum response from the dosage form which significantly lowers the side effects and reduce treatment's expense.As non-conventional pharmaceutical dos...

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Polysaccharides as Eco-Nanomaterials for Agricultural Applications

Merino¹,

Casalongué²,

Álvarez³

2017

Handbook of Ecomaterials

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The great growth of the world population, climate change, and environmental issues related to the accumulation of pesticides and fertilizers are the main problems facing the agricultural sector. To provide solutions, new innovative developments committed to caring for the environment are required. Nanotechnology has demonstrated great potential to provide new solutions to the many challenges faced by other sectors including agriculture. The aim of this work was to carry out an updated version of the problems facing the current agricultural sector and show how polysaccharide based econanomaterials might represent a promising solution. Polysaccharide applications for the controlled release of agrochemicals and promotion of plant growth are discussed. Finally, legal aspects on the development of these types of composite materials and their commercial insertion are studied.

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A rational approach towards the design of chitosan-based nanoparticles obtained by ionotropic gelation

Cited by 34 publications

References 42 publications

Physical Properties and Stability of Soft Gelled Chitosan‐Based Nanoparticles

Physical Properties and Stability of Soft Gelled Chitosan‐Based Nanoparticles

Preparation and Characterization of Cross-Linked Chitosan Microcapsules for Controlled Delivery of Oxytetracycline

Polysaccharides as Eco-Nanomaterials for Agricultural Applications

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