A Rational Approach to the Use of Topical Antiseptics

Doughty, Dorothy

doi:10.1097/00152192-199411000-00008

Cited by 39 publications

(21 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…35 Dilute Dakin’s solution for drain bulb irrigation was selected for use because of its broad antimicrobial spectrum, its tradition of use in clinical practice for infected wounds, and its low toxicity profile. 36–38 …”

Section: Discussionmentioning

confidence: 99%

Randomized Controlled Trial to Reduce Bacterial Colonization of Surgical Drains After Breast and Axillary Operations

Degnim¹,

Scow²,

Hoskin³

et al. 2013

Annals of Surgery

View full text Add to dashboard Cite

Objective To determine if bacterial colonization of drains can be reduced by local antiseptic interventions. Summary Background Drains are a potential source of bacterial entry into surgical wounds and may contribute to surgical site infection (SSI) after breast surgery. Methods Following IRB approval, patients undergoing total mastectomy and/or axillary lymph node dissection were randomized to standard drain care (control) or drain antisepsis (treated). Standard drain care comprised twice daily cleansing with alcohol swabs. Antisepsis drain care included 1) a chlorhexidine disc at the drain exit site and 2) irrigation of the drain bulb twice daily with dilute sodium hypochlorite (Dakin’s) solution. Cultures results of drain fluid and tubing were compared between control and antisepsis groups. Results Overall, 100 patients with 125 drains completed the study with 48 patients (58 drains) in the control group and 52 patients (67 drains) in the antisepsis group. Cultures of drain bulb fluid at one week were positive (1+ or greater growth) in 66% (38/58) of control drains compared to 21% of antisepsis drains (14/67), (p=0.0001). Drain tubing cultures demonstrated >50 CFU in 19% (8/43) of control drains versus 0% (0/53) of treated drains (p=0.004). SSI was diagnosed in 6 patients (6%) - 5 patients in the control group and 1 patient in the antisepsis group (p=0.06). Conclusions Simple and inexpensive local antiseptic interventions with a chlorhexidine disc and hypochlorite solution reduce bacterial colonization of drains. Based on these data, further study of drain antisepsis and its potential impact on SSI rate is warranted.

show abstract

Section: Discussionmentioning

confidence: 99%

Randomized Controlled Trial to Reduce Bacterial Colonization of Surgical Drains After Breast and Axillary Operations

Degnim¹,

Scow²,

Hoskin³

et al. 2013

Annals of Surgery

View full text Add to dashboard Cite

show abstract

“…It has antibacterial properties against both Gram‐positive and ‐negative bacteria. Studies available, however, indicate that it has limited bactericidal effectiveness 1 . In addition, it has potential cytotoxicity when applied to the healing wound 1 …”

Section: Discussionmentioning

confidence: 99%

“…Studies available, however, indicate that it has limited bactericidal effectiveness. 1 In addition, it has potential cytotoxicity when applied to the healing wound. 1 Lineaweaver and colleagues 2 demonstrated in the study using cultures of human fibroblasts that hydrogen peroxide is unsuitable for use in wound care.…”

Section: Discussionmentioning

confidence: 99%

“…1 In addition, it has potential cytotoxicity when applied to the healing wound. 1 Lineaweaver and colleagues 2 demonstrated in the study using cultures of human fibroblasts that hydrogen peroxide is unsuitable for use in wound care. In the study using the rabbit ear chamber, Brennan and Leaper 3 reported no discernible negative effect of hydrogen peroxide on microcirculation.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The Influence of 3% Hydrogen Peroxide on the Survival Rate of Hair Grafts When Used as an Antiseptic Solution for Surgical Wound Care: Experience with Five Patients

Lee

et al. 2007

Dermatol Surg

View full text Add to dashboard Cite

show abstract

“…Based on both in vitro and in vivo studies the efficiency of 0,125% Dakin's solution was confirmed against S. aureus, P. aeruginosa, E. coli and Enterococcus. [48][49][50][51] The cost, availability and simplicity of using Dakin's solution makes it one of the most commonly used bactericidal solutions.…”

Section: A Isotonic Solutionsmentioning

confidence: 99%

Negative pressure wound therapy with instillation (NPWTi): Current status, recommendations and perspectives in the context of modern wound therapy.

Bobkiewicz

Studniarek

Drews

et al. 2016

NPWTJ

View full text Add to dashboard Cite

REVIEWAbstract-Introduction of negative pressure wound therapy (NPWT) revolutionized the conception of wound healing. Currently, increasing number of studies confirmed the high efficiency of this therapy in many clinical scenarios. Moreover, some innovations have been introduced in recent years to improve the management of complex and chronic wounds. NPWT with instillation (NPWTi) combines traditional NPWT with application of topical irrigation solutions within the bed of the wound. Bioburden reduction, decreases time to wound closure, promotes granulation and tissue formation. Fewer operative visits are required when using NPWTi compared to standard NPWT. However, there are still questioned aspects of the NPWTi and thus its superiority over standard NPWT has not been fully indicated. Moreover, based on current studies no firm conclusions have been taken concerning the type of instilled solution preferably used, range of dwell-time phase, range of negative pressure and others. The main goal of the publication is to overview and summarize the current state of art concerning NPWTi. Moreover, mechanisms of action, review of the most commonly used instilled solutions are discussed and clinical evidence of NPWTi are described.

show abstract

A Rational Approach to the Use of Topical Antiseptics

Cited by 39 publications

References 8 publications

Randomized Controlled Trial to Reduce Bacterial Colonization of Surgical Drains After Breast and Axillary Operations

Randomized Controlled Trial to Reduce Bacterial Colonization of Surgical Drains After Breast and Axillary Operations

The Influence of 3% Hydrogen Peroxide on the Survival Rate of Hair Grafts When Used as an Antiseptic Solution for Surgical Wound Care: Experience with Five Patients

Negative pressure wound therapy with instillation (NPWTi): Current status, recommendations and perspectives in the context of modern wound therapy.

Contact Info

Product

Resources

About