A Rational Approach to Dental Management of Patients on Bisphosphonates

Abstract

There has been a lot of focus on osteonecrosis of the jaws associated with the usage of bisphosphonates both in dental and medical literature in recent years. However, the exact pathogenesis of bisphosphonate-related osteonecrosis of the jaws remains unclear. Against the background of emerging evidence of an evolving condition, it is not surprising that there is a lack of robust evidence-based recommendations on dental treatment of patients on bisphosphonates. This paper seeks to provide a rational approach to the dental management of patients on bisphosphonates based on current literature.

Bisphosphonate related osteonecrosis of the jaws: An update

“…This is a reliable index for evaluating the bone turnover rate and the anti-resorptive therapy. [43] Whether the serum CTX value is as a good index to predict the risk of BRONJ is controversial. Marx et al, [44] found lower serum CTX values in patients with BRONJ.…”