A ratiometric probe based on coumarin-quinoline for highly selective and sensitive detection of Zn2+ ions in living cells

Wu, Guangfu; Gao, Qi; Li, Mingxin; Tang, Xin; Lai, King Wai Chiu; Tong, Qing‐Xiao

doi:10.1016/j.jphotochem.2017.05.006

Cited by 25 publications

(5 citation statements)

References 66 publications

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“…Such confinement generally leads to improved quantum yields and reduced degradation rates, and can provide important information about detailed structural features in biological environments . Coumarins have been used as sensors for broad varieties of analytes, including cations, anions, small molecule toxicants, and biological macromolecules . Their sensitive emission spectra with a strong dependence on the local microenvironment makes coumarins excellent sensors for such environments, and their favorable photophysical properties overall facilitate their usage in high performance luminescent sensing systems. , …”

Section: Common Fluorophoresmentioning

confidence: 99%

Supramolecular Luminescent Sensors

2018

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There is great need for stand-alone luminescence-based chemosensors that exemplify selectivity, sensitivity, and applicability and that overcome the challenges that arise from complex, real-world media. Discussed herein are recent developments toward these goals in the field of supramolecular luminescent chemosensors, including macrocycles, polymers, and nanomaterials. Specific focus is placed on the development of new macrocycle hosts since 2010, coupled with considerations of the underlying principles of supramolecular chemistry as well as analytes of interest and common luminophores. State-of-the-art developments in the fields of polymer and nanomaterial sensors are also examined, and some remaining unsolved challenges in the area of chemosensors are discussed. CONTENTS 4.4. Explosives 4.5. Pharmaceutical Agents 4.6. Biologically Relevant 4.6.1. Adenosine Triphosphate (ATP)

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Section: Common Fluorophoresmentioning

confidence: 99%

Supramolecular Luminescent Sensors

2018

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“…Chemosensors for Zn 2+ are mainly based on the complexation around the coumarin core ( 160 – 173 , Figure ), − but due to the similarity with other metal cations, these probes often still lack specificity.…”

Section: Fluorescent Chemosensors Based On Coumarin Platform For Meta...mentioning

confidence: 99%

“…An alternative appended ligand-based fluorescent sensor 172 demonstrated a high selectivity for Zn 2+ with a ratiometric response, forming a 1:1 complex. The fluorescence band centered at 516 nm in an aqueous medium containing 25% ACN is gradually reduced upon the addition of Zn 2+ , with the appearance of a new fluorescent band at 566 nm, with a ratiometric enhancement ( F 566 / F 516 ) of approximately 4.3-fold, while no other metal ions either elicited a similar fluorescent response or interfered with the fluorescence sensing of Zn 2+ .…”

Section: Fluorescent Chemosensors Based On Coumarin Platform For Meta...mentioning

confidence: 99%

“…7-Diethylamino coumarin derivatives 249−251 336 (Figure 156) were assessed for their sensing ability with H 2 S. Although 249 is not reactive toward H 2 S, the extended chromophores response to H 2 S is impressive with 4765-fold (250) or 615-fold (251) ratiometric fluorescence enhancements as a result of the reduction of the appended nitro group (Figure 157). Both probes demonstrated good selectivity in the presence of other sulfur species, and whereas 250 was previously described as a sensor for cyanide and GSH, this posed no selectivity problems as the excitation and emission wavelengths involved in the reaction products with those analytes are different.…”

Section: Chemical Reviewsmentioning

confidence: 99%

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Coumarin-Based Small-Molecule Fluorescent Chemosensors

et al. 2019

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Coumarins are a very large family of compounds containing the unique 2H-chromen-2-one motif, as it is known according to IUPAC nomenclature. Coumarin derivatives are widely found in nature, especially in plants and are constituents of several essential oils. Up to now, thousands of coumarin derivatives have been isolated from nature or produced by chemists. More recently, the coumarin platform has been widely adopted in the design of small-molecule fluorescent chemosensors because of its excellent biocompatibility, strong and stable fluorescence emission, and good structural flexibility. This scaffold has found wide applications in the development of fluorescent chemosensors in the fields of molecular recognition, molecular imaging, bioorganic chemistry, analytical chemistry, materials chemistry, as well as in the biology and medical science communities. This review focuses on the important progress of coumarin-based small-molecule fluorescent chemosensors during the period of 2012− 2018. This comprehensive and critical review may facilitate the development of more powerful fluorescent chemosensors for broad and exciting applications in the future.

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“…Appropriate intake of Zn 2+ ions has speci c bene ts for the human body. However, too high or too low levels of Zn 2+ can cause profound human disease states [10][11]. For example, physical growth retardation and neurological disorders like Alzheimer's can result from Zn 2+ de ciencies [12][13].…”

Section: Introductionmentioning

confidence: 99%

A Fluorescent Probe Based on the Hydrazone Schiff Base for the Detection of Zn2+ and its Application on Test Strips

Zhang

et al. 2023

J Fluoresc

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A novel uorescent probe SHK for Zn 2+ detection was designed based on the hydrazone Schiff base, successfully synthesized by Suzuki coupling and condensation reactions. The probe SHK in DMSO/H 2 O showed extremely weak uorescence. However, the solution exhibited an intensive yellow-green emission with the introduction of Zn 2+ . In contrast, negligible uorescence change was observed when other metal ions were added, suggesting a high selectivity of SHK for Zn 2+ detection. The Job's Plot analysis revealed that a 1:1 stoichiometric adduct SHK-Zn 2+ formed during the Zn 2+ sensing. The binding constant of the complex was determined to be 184 M − 1 , and the detection limit for Zn 2+ was calculated to be 112 µM.Moreover, the probe SHK achieved selective uorescence sensing for Zn 2+ on test strips, which guaranteed its practical application prospect.

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A ratiometric probe based on coumarin-quinoline for highly selective and sensitive detection of Zn2+ ions in living cells

Cited by 25 publications

References 66 publications

Supramolecular Luminescent Sensors

Supramolecular Luminescent Sensors

Coumarin-Based Small-Molecule Fluorescent Chemosensors

A Fluorescent Probe Based on the Hydrazone Schiff Base for the Detection of Zn2+ and its Application on Test Strips

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