A rat model of the 131I-induced changes in thyroid function

Reilly, C P; Symons, R. G.; Wellby, M.L.

doi:10.1007/bf03346944

Cited by 14 publications

(13 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We found decreased serum www.bjournal.com.br T4 concentrations, while TSH was significantly increased. These findings were in accordance with an earlier report by Reilly et al (16). However, Railly et al showed no change in T3 concentration 85 days after administration of 131 I in their Wistar rat model, our Fisher rat model showed a significant decrease of T3 concentration 3 and 5 months after 131 I administration.…”

Section: Discussionsupporting

confidence: 93%

131I-induced changes in rat thyroid gland function

Torlak¹,

Zemunik²,

Modun³

et al. 2007

Braz J Med Biol Res

View full text Add to dashboard Cite

Therapeutic doses of 131 I administered to thyrotoxic patients may cause thyroid failure. The present study used a rat model to determine thyroid function after the administration of different doses of 131 I (64-277 µCi). Thirty male Fisher rats in the experimental group and 30 in the control group (untreated) were followed for 6 months. The animals were 4 months old at the beginning of the experiment and were sacrificed at an age of 9 months. Hormone concentration was determined before 131 I administration (4-month-old animals) and three times following 131 I administration, when the animals were 7, 8, and 9 months old. The thyroid glands were removed and weighed, their volume was determined and histopathological examination was performed at the end of the experiment. Significant differences in serum triiodothyronine and thyroid-stimulating hormone concentration, measured at the age of 7, 8, and 9 months, were found in the experimental group. During aging of the animals, the concentration of thyroxin fell from 64.8 ± 8.16 to 55.0 ± 6.1 nM in the control group and from 69.4 ± 6.9 to 25.4 ± 3.2 nM in the experimental group. Thyroid gland volume and weight were significantly lower in the experimental than in the control group. Thyroid glands from the experimental group showed hyaline thickness of the blood vessel wall, necrotic follicles, a strong inflammatory reaction, and peeling of necrotic cells in the follicles. In conclusion, significant differences in hormone levels and histopathological findings indicated prolonged hypothyroidism after 131 I administration to rats, which was not 131 I dose dependent. Correspondence

show abstract

Section: Discussionsupporting

confidence: 93%

131I-induced changes in rat thyroid gland function

Torlak¹,

Zemunik²,

Modun³

et al. 2007

Braz J Med Biol Res

View full text Add to dashboard Cite

show abstract

“…The first I-131 dose that we injected into rats was low so as not to effect the thyroid tissue functions, as in the literature. 19 Indeed, the mean injected low dose of I-131 was 51.54 Ϯ 8.6 Ci in our study.…”

Section: Discussionmentioning

confidence: 94%

“…In the same study, the I-131 cleared with a half-life of 3.38 Ϯ 0.61 days. 19 In the light of this previous study, we thought that approximately 50 Ci of I-131 would be suitable for low-dose application. The first I-131 dose that we injected into rats was low so as not to effect the thyroid tissue functions, as in the literature.…”

Section: Discussionmentioning

confidence: 98%

Evaluation of the Cell Death Pathway and Apoptosis-Stunning Effect Relationship After Low- and High-Dose I-131 Administrations in Rat Thyroid Tissue

Turgut

Babül²,

Özdemir³

et al. 2006

Cancer Biotherapy and Radiopharmaceuticals

View full text Add to dashboard Cite

Following I-131 administration, two types of cell death--both apoptosis and necrosis findings--have been observed in most of the rats. We think that the decreased uptake values are because of the probable stunning effect in thyroid tissue. We also investigated whether the stunning effect is related to apoptosis. According to our results, it can be concluded that the stunning effect is not related to tissue damage, cell decrease, or cell death. Alternatively, we think that this can be related to a radiation-induced reduction of iodine uptake/metabolism or a modified iodine transport mechanism. For further in vivo studies, this experimental model using normal rat thyroid tissue may be useful in investigating the cell death pathways induced by I-131 and its probable roles in the development of the stunning phenomenon.

show abstract

“…131 I is cleared with a half-life of 3.38 Ϯ 0.01 days (Reilly et al, 1986). Taking into account the fact that female rats of this experimental group were exposed to the radioactive iodine no less than twelve days before mating (more than the 10-fold time of effective half-life of the 131 I up to beginning of embryo's thyroid iodine intake), the development of fetuses in this group took place in a state of 131 I-induced maternal hypothyroidism without the influence of direct effects of radioactive iodine.…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical study of fibronectin and thyroglobulin in the thyroid gland of female rats after exposure to radioactive iodine

Usenko¹,

Lepekhin

Kornilovska³

et al. 1998

Anat. Rec.

View full text Add to dashboard Cite

The aim of this work was to study the effect of a dose of 150 µCi 131 I on the barrier properties of the thyroid epithelium in pregnant female rats. Thirty-five female Wistar rats were divided into a control and four experimental groups (each distinguished by the time of 131 I injection: group I-no less then 12 days before mating; groups II, III, and IV-on 5th, 10th, and 16th days of gestation, respectively). The thyroid glands were fixed in Bouin's fluid, embedded in paraffin, and stained immunohistochemically for thyroglobulin and fibronectin. In group IV the appearance of follicles with fibronectin-positive colloid demonstrates the penetration of blood plasma into the follicular lumen. There are more fibronectin positive follicles in group III. Regardless of the nature of the follicles' contents, numerous thyrocytes with an intensive fibronectin positive reaction begin to appear in the follicles. In group II the number of fibronectin positive follicles and thyrocytes is clearly reduced, and in group I only a few remain. In group IV there is a noticeable reduction in the quantity of colloid inside the follicles and often an absence of any thyroglobulin positive reaction. There are thyrocytes in which thyroglobulin positive granules localized in the basal zone. There is thyroglobulin positive staining in the stroma and blood vessels. In group II thyroglobulin is no longer found in the stroma. Small doses of 131 I provoke a serious breakdown in the thyroid epithelium's barrier properties, although these changes are of a transient nature. The central zone of the thyroid gland reacts more actively and dynamically to exposure to radioactive iodine than the peripheral zone. Anat.

show abstract

A rat model of the 131I-induced changes in thyroid function

Cited by 14 publications

References 10 publications

131I-induced changes in rat thyroid gland function

131I-induced changes in rat thyroid gland function

Evaluation of the Cell Death Pathway and Apoptosis-Stunning Effect Relationship After Low- and High-Dose I-131 Administrations in Rat Thyroid Tissue

Immunohistochemical study of fibronectin and thyroglobulin in the thyroid gland of female rats after exposure to radioactive iodine

Contact Info

Product

Resources

About