A Rare Variant of Multicentric Large B-cell Lymphoma with Plasmacytoid and Mott Cell Differentiation in a Dog

Snyman, Heindrich N.; Fromstein, J.M.; Vince, Andrew

doi:10.1016/j.jcpa.2012.08.002

Cited by 10 publications

(24 citation statements)

References 23 publications

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“…Because the diagnosis of primary CNS lymphoma ultimately depends on a rigorous postmortem examination to exclude underlying involvement of other organs, 2 the few case reports of primary CNS lymphoma in the veterinary literature are controversial. 3,17,32,37 It is hoped that this rigorous approach will lead to better designed prospective studies to confirm the hypothesis developed from this study that these histological patterns, together with their MRI profiles (Sturges et al, in preparation), accurately reflect targeting of specific anatomical compartments, which is in turn dependent on the expression of different homing molecules among the lymphoma subtypes. Such studies would lead to improved clinical diagnosis and prognosis, better understanding of the molecular pathogenesis, and innovative therapeutic targeting nervous system lymphoma.…”

Section: Discussionsupporting

confidence: 56%

Canine Nervous System Lymphoma Subtypes Display Characteristic Neuroanatomical Patterns

et al. 2016

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Primary and secondary nervous system involvement occurs in 4% and 5%-12%, respectively, of all canine non-Hodgkin lymphomas. The recent new classification of canine malignant lymphomas, based on the human World Health Organization classification, has been endorsed with international acceptance. This histological and immunocytochemical classification provides a unique opportunity to study the histologic anatomic distribution patterns in the central and peripheral nervous system of these defined lymphoma subtypes. In this study, we studied a cohort of 37 dogs with lymphoma, which at necropsy had either primary (n = 1, 2.7%) or secondary (n = 36; 97.3%) neural involvement. These T- (n = 16; 43.2%) or B-cell (n = 21; 56.8%) lymphomas were further classified into 12 lymphoma subtypes, with predominant subtypes including peripheral T-cell lymphoma (PTCL) or diffuse large B-cell lymphoma (DLBCL), respectively. This systematic study identified 6 different anatomically based histologically defined patterns of lymphoma infiltration in the nervous system of dogs. Different and distinct combinations of anatomical patterns correlated with specific lymphoma subtypes. Lymphoma infiltration within the meningeal, perivascular, and periventricular compartments were characteristic of DLBCL, whereas peripheral nerve involvement was a frequent feature of PTCL. Similarly cell counts above 64 cells/μL in cerebrospinal samples correlated best with marked meningeal and periventricular lymphoma infiltration histologically. Prospective studies are needed in order to confirm the hypothesis that these combinations of histological neuroanatomic patterns reflect targeting of receptors specific for the lymphoma subtypes at these various sites.

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Section: Discussionsupporting

confidence: 56%

Canine Nervous System Lymphoma Subtypes Display Characteristic Neuroanatomical Patterns

et al. 2016

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“…MUM1 is a transcription factor expressed in plasma cells. 13 In our case, as in previously reported cases, 7,14 cells with Mott cell differentiation expressed nuclear immunohistochemical positivity for MUM1 (Figure C). The presence of scattered CD3 positive T-cells (Figure 3 D) was interpreted to be due to the presence of tumor infiltrating T lymphocytes.…”

Section: Discussionsupporting

confidence: 88%

Lymphoma with Mott cell differentiation and validation of immunohistochemical lymphoid markers in an African pygmy hedgehog (Atelerix albiventris)

Cazzini

Richardson

Smith

et al. 2019

Veterinary Clinical Pathol

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A 2 year old, female entire African pygmy hedgehog was presented for diagnostic investigation of a 2-month reduction in appetite, with weight loss, and recent vomiting.Clinical examination revealed a large, firm mass originating from the left cranial abdomen.Ultrasound guided fine needle aspirates of the mass, the liver and the mesenteric lymph nodes revealed a population of pleomorphic round cells, some of which contained variable numbers of round, clear vacuoles, consistent with a diagnosis of lymphoma with Mott cell differentiation. At post-mortem examination, there was marked diffuse splenic enlargement, with infiltration by a soft tissue mass. There were multiple coalescing masses in the liver, pallor of the kidneys, and enlargement of the mesenteric lymph nodes. On histological

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“…In domestic animals, B‐cell lymphomas with similar morphologic features as SRCL were reported as B‐cell lymphoma with Mott cell differentiation . However, in the previous reports, it was unclear whether the neoplastic cells originated from follicular lymphocytes . In the current case, lymphoid follicle origin was not evident on histopathologic or immunohistochemical examination.…”

Section: Discussionmentioning

confidence: 57%

“…Signet ring cell lymphoma of the B‐cell type is a cytologic variant of follicular lymphoma in people and pigs . In domestic animals, B‐cell lymphomas with similar morphologic features as SRCL were reported as B‐cell lymphoma with Mott cell differentiation . However, in the previous reports, it was unclear whether the neoplastic cells originated from follicular lymphocytes .…”

Section: Discussionmentioning

confidence: 99%

“…However, MUM1 is also expressed in various B‐cell non‐Hodgkin lymphomas in people, including diffuse large B‐cell lymphoma and small lymphocytic lymphoma . This suggests that there is a gradient of differentiation between B‐cell lymphomas and plasmacytomas, and that this influences the immunoreactivity of cells to various cell markers, including MUM1 …”

Section: Discussionmentioning

confidence: 99%

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B‐cell lymphoma with Mott cell differentiation in a cat

Kanehara

Matsui

Murakami

et al. 2016

Veterinary Clinical Pathol

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A 12-year-old, male castrated Domestic Shorthair cat was presented to Animal Medical Center of Gifu Univeristy with anorexia and vomiting. Physical examination revealed an enlarged left tonsil and right mandibular lymph node (approximately 2-3× the normal size), and a submucosal mass on the right side of the epiglottis (1.5 × 2.0 cm). On computed tomography images, an enlarged left tonsil, and enlarged right mandibular, right pharyngeal, and left and right cervical lymph nodes were observed. Cytologic examination of smears of tonsil and lymph nodes revealed numerous medium- to large-sized neoplastic lymphoid cells, approximately half of which contained one or several light-blue homogenous globoid cytoplasmic inclusions (5-10 μm), which stained magenta with periodic acid-Schiff (PAS) stain. Histopathologic examination of the left tonsil revealed diffuse proliferation of medium- to large-sized neoplastic lymphoid cells effacing the original lymphoid architecture. Half of the cells contained one or several eosinophilic globoid cytoplasmic inclusions, which stained magenta with PAS and showed positive immunohistochemical reactions for immunoglobulin M (IgM) and λ light chain. Neoplastic lymphoid cells were also CD20 , Pax5 , and MUM1 , and CD3 . Thus, the neoplastic lymphoid cells expressed a B-cell immunophenotype, and the globoid cytoplasmic inclusions represented an aberrant IgM λ light chain accumulation, similar to Russell bodies. B-cell lymphoma with Mott cell differentiation was diagnosed based on cytologic, histopathologic, and immunohistochemical features. This is the first report of B-cell lymphoma with Mott cell differentiation in a cat.

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A Rare Variant of Multicentric Large B-cell Lymphoma with Plasmacytoid and Mott Cell Differentiation in a Dog

Cited by 10 publications

References 23 publications

Canine Nervous System Lymphoma Subtypes Display Characteristic Neuroanatomical Patterns

Canine Nervous System Lymphoma Subtypes Display Characteristic Neuroanatomical Patterns

Lymphoma with Mott cell differentiation and validation of immunohistochemical lymphoid markers in an African pygmy hedgehog (Atelerix albiventris)

B‐cell lymphoma with Mott cell differentiation in a cat

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