A Rare Type of Bladder Ulcer in Women; Report of Cases

Hunner, Guy L.

doi:10.1056/nejm191505061721802

Cited by 252 publications

(99 citation statements)

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“…IC as described originally by Hanash and Pool is characterized by urinary symptoms of severely reduced bladder capacity and cystoscopic findings of Hunner's ulcers [Hunner, 1918], which are patches of reddened mucosa exhibiting small vessels radiating to a central pale scar [Hanash and Pool, 1969]. However, the more frequent presentation of IC is the nonulcerative variety, which is characterized by glomerulation and submucosal hemorrhages.…”

Section: Presentation and Diagnosismentioning

confidence: 99%

Role of inflammation in bladder function and interstitial cystitis

Grover

Srivastava

Lee

et al. 2011

Therapeutic Advances in Urology

167

140

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Cystitis, or inflammation of the bladder, has a direct effect on bladder function. Interstitial cystitis is a syndrome characterized by urinary bladder pain and irritative symptoms of more than 6 months duration. It commonly occurs in young to middle-aged women with no known cause and in fact represents a diagnosis of exclusion. Many factors have been suggested, including chronic or subclinical infection, autoimmunity and genetic susceptibility, which could be responsible for initiating the inflammatory response. However, a central role of inflammation has been confirmed in the pathogenesis of interstitial cystitis. Patients with interstitial cystitis are usually managed with multimodal therapy to break the vicious cycle of chronic inflammation at every step. Patients who develop irreversible pathologies such as fibrosis are managed surgically, which is usually reserved for refractory cases.

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Section: Presentation and Diagnosismentioning

confidence: 99%

Role of inflammation in bladder function and interstitial cystitis

Grover

Srivastava

Lee

et al. 2011

Therapeutic Advances in Urology

167

140

View full text Add to dashboard Cite

show abstract

“…2 Up until 2002, the National Institute for Diabetes and Digestive and Kidney Diseases (NIDDK) criteria were used to define IC. 3 However, it was recognized that the NIDDK criteria were designed to delineate a homogeneous population for research trials and were overly restrictive for use in routine clinical practice.…”

Section: Terminologymentioning

confidence: 99%

CUA guideline: Diagnosis and treatment of interstitial cystitis/ bladder pain syndrome

Cox

Golda

Nadeau

et al. 2016

CUAJ

113

121

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MethodologyThe following guidelines were based on MEDLINE and PUBMED searches of English language literature, in addition to consensus conference proceedings. Levels of evidence and grades of recommendation were assigned for each investigation and treatment, as per the modified Oxford Centre for Evidence-Based Medicine grading system. Where the literature was inconsistent or scarce, a consensus expert opinion was generated to provide treatment guidelines.

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“…Interstitial cystitis was first reported in 1915, when Hunner described it as "a rare type of bladder ulcer in women" (10). Despite its longstanding recognition, the etiology of interstitial cystitis remains uncharacterized.…”

Section: Discussionmentioning

confidence: 99%

Severe Interstitial Cystitis Associated with Sjoegren's Syndrome

et al. 2004

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A 53-year-old woman presented with oliguria, urinary frequency, abdominal pain and severe edema of the lower extremities. Her serum creatinine was 8.1 mg/dl. Computed tomographic and ultrasonographic studies showed a severely dilated urinary bladder, and bilateral hydroureteronephrosis. Examination of a urinary bladder biopsy specimen showed subepithelial edema and infiltration by lymphocytes and plasmacytes. However, the patient complainted of dry mouth and dry eyes. Ophthalmologically, the Schirmer test was positive. A biopsy of the minor salivary glands in the lip showed chronic sialoadenitis. A diagnosis of Sjögren's syndrome complicated by interstitial cystitis was made. Since she had been anuric, secondary to urinary obstruction, intermittent self-catheterization was started. Combination of corticosteroid and cyclosporin therapy was initiated. Spontaneous urination began, and gradually the patient's symptoms remitted. After 8 months of therapy, bladder capacity increased from 140 ml to 350 ml, and she voided approximately 1,200 ml by herself and 600 ml by catheterization daily. This case suggests that when severe interstitial cystitis is associated with Sjögren's syndrome, a therapeutic trial of corticosteroids and cyclosporin may be beneficial. (Internal Medicine 43: 248-252, 2004)

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A Rare Type of Bladder Ulcer in Women; Report of Cases

Cited by 252 publications

References 0 publications

Role of inflammation in bladder function and interstitial cystitis

Role of inflammation in bladder function and interstitial cystitis

CUA guideline: Diagnosis and treatment of interstitial cystitis/ bladder pain syndrome

Severe Interstitial Cystitis Associated with Sjoegren's Syndrome

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