A rare presentation of a splenic abscess

Weledji, Elroy Patrick; Zouna, Frank

doi:10.1002/ccr3.5493

Cited by 1 publication

(4 citation statements)

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“…Both the conditions of splenic NHL and splenic abscess can cause leukocytosis, anemia, an increased ESR, and an elevated lactate dehydrogenase (LDH) [11,12]. These similar initial laboratory findings make it challenging to distinguish the specific underlying cause; however, anemia in the case of splenic NHL tends to be of the hemolytic type or anemia of chronic disease.…”

Section: Laboratory Evaluationmentioning

confidence: 99%

“…In addition, thrombocytosis, lymphocytosis, and pancytopenia are more predictive of splenic NHL. Other diagnostic biological markers for NHL include serological, immunophenotypic, and molecular markers [9,11,12]. Immunoreactivity, i.e., the presence of Bcl-2, which is an antiapoptotic protein, can distinguish the malignant cells of lymphoma from benign reactive B cells in the marginal zone of the spleen [11,12].…”

Section: Laboratory Evaluationmentioning

confidence: 99%

“…Other diagnostic biological markers for NHL include serological, immunophenotypic, and molecular markers [9,11,12]. Immunoreactivity, i.e., the presence of Bcl-2, which is an antiapoptotic protein, can distinguish the malignant cells of lymphoma from benign reactive B cells in the marginal zone of the spleen [11,12]. In contrast to NHL, serum protein and immunoglobulin tests are not helpful in splenic abscesses; however, blood cultures may be optimistic [12].…”

Section: Laboratory Evaluationmentioning

confidence: 99%

“…Immunoreactivity, i.e., the presence of Bcl-2, which is an antiapoptotic protein, can distinguish the malignant cells of lymphoma from benign reactive B cells in the marginal zone of the spleen [11,12]. In contrast to NHL, serum protein and immunoglobulin tests are not helpful in splenic abscesses; however, blood cultures may be optimistic [12]. Thus, further workup is needed to evaluate the exact cause.…”

Section: Laboratory Evaluationmentioning

confidence: 99%

See 3 more Smart Citations

The Diagnostic Dilemma of Splenic Non-Hodgkin’s Lymphoma and Splenic Abscess: A Narrative Review

Khan¹,

Aisha²,

Farkouh³

et al. 2022

Cureus

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Non-Hodgkin's lymphoma (NHL) is a lymphoproliferative disorder that principally displays lymph node involvement but can also spread to extranodal sites such as the spleen. Primary splenic NHL arises in the spleen and, due to its atypical presentation, can sometimes present similarly to other splenic conditions. This review aims to highlight how primary splenic NHL can be effectively differentiated from other splenic conditions, such as splenic abscesses. PubMed, MEDLINE, Scopus, Google, and Google Scholar were used to identify articles mainly focused on splenic non-Hodgkin's lymphoma and splenic abscess. The search was limited to articles published from January 2005 to November 2022. Of the 229 total articles amassed, only 34 were selected and narratively reviewed. From a thorough review of the current literature, it is evident that splenic NHL displays a similar clinical picture to other splenic conditions, namely splenic abscesses. One cannot easily differentiate between the two conditions, both clinically and via diagnostic imaging. Lymphadenopathy, a hallmark sign of nodal NHL, may or may not be present in splenic NHL. Ultimately, splenectomy with biopsy and immunohistochemical staining (IHC) may be required to confirm the diagnosis. In cases of suspected splenic NHL or splenic abscess with little-to-no symptomatic improvement after medication administration, splenectomy followed by histopathological examination may be required for a definitive diagnosis and proper treatment.

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Section: Laboratory Evaluationmentioning

confidence: 99%