A rare new presentation of pemphigus vulgaris

Mozafari, Nikoo; Ganji, Raziyeh; Toossi, Parviz

doi:10.1002/ccr3.5979

Cited by 2 publications

(3 citation statements)

References 9 publications

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“…Pemphigus results in large irregular areas of ulcers caused by flaccid or easily rupturable thin-walled bullae with extensive labial involvement, which is not observed in BP. Adverse drug reactions are an undesirable and a usually unanticipated response, independent of the intended therapeutic purpose of the medication, which may be either immunologic (i.e., drug allergy) or non-immunologic (i.e., drug intolerance) which accounts for 90% of the adverse drug reactions (46). Chronic urticaria is most often idiopathic; however, 50% of cases have an autoimmune basis, characterized by triple response erythema caused by vasodilatation, increased vascular permeability (wheal) and axon reflex (flare) produced by the stimulation of cutaneous sensory nerve endings, with antidromic conduction of the impulse and release of the neurokinin substance P. Substance P is a vasodilator that causes the release of histamine and other mediators from cutaneous mast cells, thus augmenting the urticarial lesions (47).…”

Section: Differential Diagnosismentioning

confidence: 99%

Recurrent bullous pemphigoid: A case report and literature review

et al. 2023

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The present study aimed to enhance the current understanding of the etiopathogenesis, predisposing factors, clinical features and current management modalities for bullous pemphigoid (BP). BP is a chronic autoimmune disorder mediated by antibodies targeting BP180, a type XVII collagen (BPAG2), and BP230, a hemidesmosome protein located in basal keratinocytes, resulting in the formation of subepithelial blisters and multiple chronic oral ulcers, which heal without scarring, as well as urticarial lesions on the extremities. The BP lesions occur in the oral cavity following the onset of pruritic papules in the extremities. The present study describes the case of a patient with recurrent BP who was hypertensive and treated with amlodipine. In addition, a detailed search was performed on the PubMed database by searching the key word 'bullous pemphigoid'; ~33 articles were selected which were published from 2005-2022 for inclusion and discussion in the literature review. Studies published prior to 2005 were excluded. The anti-hypertensive drug, amlodipine, has a high propensity for BP lesions. However, caution needs to be taken when prescribing amlodipine for hypertension. The occurrence of BP must not be overlooked, and the oral physician must seek a complete detailed drug history and clinical examination, which will aid in the diagnosis of BP. BP lesions are usually multiple and have a chronicity and usually affects the oral mucosa, upper torso and arms. There is a period of exacerbations and remissions. On the whole, the present study provides insight into the etiology, predisposing risk factors, etiopathogenesis, clinical features and management modalities for BP.

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Section: Differential Diagnosismentioning

confidence: 99%

Recurrent bullous pemphigoid: A case report and literature review

et al. 2023

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“…8 In one rare case, a female patient presented with ulcerated plaques on her foot that did not seem to heal. 9 Patients are susceptible to extensive keloid scarring after a severe flare of the PV and superinfection. 10 Full-blown PV may be prevented by early intervention at the point of oral eruptions or skin lesions.…”

Section: Introductionmentioning

confidence: 99%

“…PV has infrequent presentations such as epigastric pain radiating to the neck caused by bleeding esophageal ulcer in the absence of a typical oral lesion 8 . In one rare case, a female patient presented with ulcerated plaques on her foot that did not seem to heal 9 . Patients are susceptible to extensive keloid scarring after a severe flare of the PV and superinfection 10 .…”

Section: Introductionmentioning

confidence: 99%