A rare neurendocrine tumor of the lung: sclerosing paraganglioma. A neoplasm that is difficult to diagnose and a source of dangerous pitfalls. A case report and literature review

Abstract

Summary An endobronchial obstructing neoformation was found in a 58-year-old man. The histology and immunohistochemical profile oriented the authors towards a diagnosis of paraganglioma, sclerosing variant. This very difficult diagnosis, especially in a pulmonary localization, may lead to erroneous conclusions both in terms of histogenetic interpretation and that of its biological behavior. The pulmonary localization of the paraganglioma is very rare and even more rare the sclerosing variant, recently reported. Differential diagnosis and literature are discussed.

Primary Pulmonary Paraganglioma, Case Report and Review of the Literature

“…There seems to be no difference in incidence between the right and left lungs; however, the lower lobe appears to be the most affected. On gross examination all pulmonary PGs were well circumscribed, presenting in some cases a well-formed brous capsule 13 , Table 1 and 2 Kim et al 19 (+) (+) (+/-) (+) (+) (+/-) Zhang et al 23 (+) Skødt et al 13 (-) (+) (+) (-) (+) (+) Saeki et al 16 (+) (+) (+) Kaplan R et al 14 (+) (+) (-) (+) (+) (+) Africa et al 15…”