A rare gastric neuroendocrine carcinoma coexisting with Brunner's gland adenoma: A case report

Abstract

Abstract. Gastric neuroendocrine carcinoma (G-NEC) is a rare neoplasm known for its aggressive behavior and poor prognosis. Brunner's gland adenoma (BGA) is a rare benign proliferative lesion that develops most commonly in the duodenum. To the best of our knowledge, no cases of G-NEC coexisting with BGA have previously been reported. The present study therefore reports the first case of G-NEC combined with BGA. A 67-year-old female presented with upper abdominal discomfort. No distant metastases were detected upon pre-operative abdominal computed tomography imaging. The patient underwent a radical distal gastrectomy, D2 lymphadenectomy and Billroth I gastroenterostomy. The resected masses were histologically confirmed to be G-NEC and BGA, respectively. The patient did not receive neoadjuvant or adjuvant chemotherapy or radiotherapy, and remains alive with no evidence of metastasis or recurrence at four years post-surgery.

A Rare Tumor of the Duodenum, Brunner s Gland Adenoma: A Case Report

“…In the literature, there is no accepted or applied formal guideline for the follow-up and treatment of BGA. However, because it can coexist with adenocarcinoma, high-grade dysplasia, and neuroendocrine tumors, resection of the BGA is recommended (1,3,11,12). While endoscopic mucosal resection (EMR) and snare polypectomy are preferred for resection of pediculated, small, and superficial submucosal localized BGA lesions, surgical resection is used for lesions in large and difficult anatomical regions that spread deep into the submucosa (2,5,10).…”