A Rare Concurrence of Hodgkin’s Lymphoma, Sickle Cell Disease and Diabetes Mellitus

Toorani, Zainab Abdulmajeed; Sridhar, Srishma; Roque, Wilfredo

doi:10.12816/0047565

Cited by 2 publications

(3 citation statements)

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“…Lymphomas Hodgkin's (HL) and non-Hodgkin's (NHL), extranodal non-Hodgkin lymphoma (EN-NHL)) are other common malignancies affecting both young and adult Saudi [16] – [19] . The prevalence of HL (uncommon type) was reported as 3.4% in Saudi Arabia with high clinical variability and frequently observed among the age-range 15–35 years [20] – [22] .…”

Section: Introductionmentioning

confidence: 99%

Epidemiology of cancer in Saudi Arabia thru 2010–2019: a systematic review with constrained meta-analysis<span style="font-size: 12px"> Running title: epidemiology of cancer in Saudi Arabia thru 2010–2019</span>

et al. 2020

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Background Cancer is emerging as a major global health-care system challenge with a growing burden worldwide. Due to the inconsistent cancer registry system in Saudi Arabia, the epidemiology of cancer is still dispersed in the country. Consequently, this review aimed to assemble the epidemiological metrics of cancer in Saudi Arabia in light of the available published data during the period from (2010–2019). Methods Published literature from Saudi Arabia relating to cancer incidence, prevalence, risk factors, and other epidemiological metrics were accessed through electronic search in Medline/PubMed, Cochrane, Scopus, Web of Knowledge, Google Scholar, and public database that meet the inclusion criteria. Relevant keywords were used during the electronic search about different types of cancers in Saudi Arabia. No filters were used during the electronic searches. Data were pooled and odds ratios (ORs) and 95% confidence interval (95%CI) were calculated. A random-effects meta-analysis was performed to assess the well-determined risk factors associated with different types of cancers. Results The most common cancers in Saudi Arabia are breast, colorectal, prostate, brain, lymphoma, kidney and thyroid outnumbering respectively. Their prevalence rates and OR (95%CI) as follow: breast cancer 53% and 0.93 (0.84–1.00); colon-rectal cancer (CRC) 50.9% and 1.2 (0.81–1.77); prostate cancer 42.6% and 3.2 (0.88–31.11); brain/Central Nervous System cancer 9.6% and 2.3 (0.01–4.2); Hodgkin and non-Hodgkin's lymphoma 9.2% and 3.02 (1.48–6.17); kidney cancer 4.6% and 2.05 (1.61–2.61), and thyroid cancer 12.9% and 6.77 (2.34–19.53). Conclusion Within the diverse cancers reported from Saudi Arabia, the epidemiology of some cancers magnitude 3-fold in the latest years. This increase might be attributed to the changing in the Saudi population lifestyle (adopting western model), lack of cancer awareness, lack of screening & early detection programs, social barriers toward cancer investigations. Obesity, genetics, sedentary lifestyle, tobacco use, viral infection, and iodine & Vit-D deficiency represent the apparent cancer risk factors in Saudi Arabia.

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Section: Introductionmentioning

confidence: 99%

Epidemiology of cancer in Saudi Arabia thru 2010–2019: a systematic review with constrained meta-analysis<span style="font-size: 12px"> Running title: epidemiology of cancer in Saudi Arabia thru 2010–2019</span>

et al. 2020

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“…The significance of these secreted, solubilized molecules has been addressed in several previous studies addressing autoimmune diseases, [46][47][48] metabolic disorders, 49 infectious diseases, 50,51 and malignancies. 52 They have been also regarded as sensitive and specific biomarkers in the diagnosis of some disorders, 53 increasing the importance of studying these molecules among CD patients.…”

Section: Discussionmentioning

confidence: 99%

“…CD16 and CD163 are released from the surface of the monocytes/macrophages by proteolysis in response to oxidative stress or inflammatory stimulation and exerts their immunoregulatory effects on distant cells, organs, or tissues. The significance of these secreted, solubilized molecules has been addressed in several previous studies addressing autoimmune diseases, 46‐48 metabolic disorders, 49 infectious diseases, 50,51 and malignancies 52 . They have been also regarded as sensitive and specific biomarkers in the diagnosis of some disorders, 53 increasing the importance of studying these molecules among CD patients.…”

Section: Discussionmentioning

confidence: 99%

The expansion of CD14+ CD163+ subpopulation of monocytes and myeloid cells‐associated cytokine imbalance; candidate diagnostic biomarkers for celiac disease (CD)

Babania

Mohammadi

Yaghoubi³

et al. 2021

Clinical Laboratory Analysis

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Celiac disease (CD) is a chronic autoimmune disorder of small intestine against dietary gluten, among genetically predisposed individuals. Monocytes are versatile innate immune cells involved in the regulation of inflammation, and strongly involved in the intestinal immunity. However, the role of monocytes and their subtypes in CD is not well demonstrated.Methods: Here, we assessed the polarization of CD14+ monocytes by evaluating the M1 (CD16) and M2 (CD163) markers by flowcytometry, their soluble forms (sCD16 and sCD163), and the serum levels of IL-10, IL-12, TGFβ, and TNFα cytokines using ELISA method, among 30 CD patients and 30 sex-and age-matched healthy subjects (HS). We also analyzed the diagnostic values of all variables with significant differences.Results: CD14+CD163+ monocytes were more frequent in CD patients than HS, while CD14+CD16+ monocytes were higher in HS. IL-10and TNFα increased, and TGFβ expression was decreased among CD patients. The sCD16 serum levels were elevated in patients, while sCD163 was higher but not significant among CD patients.CD163+/CD16+ and IL-10/IL-12 ratios were higher in CD patients, and TGFβ/TNFα ratio was higher in HS group. IL-10, CD14+CD163+, TNFα, and IL-10/IL-12 ratios with the AUC over 0.7 were introduced as fair diagnostic markers. Our findings revealed that the M2 (CD14+CD163+) monocytes were more frequent among CD patients, and the cytokine balance was disturbed. Conclusion:According to the significant functional diversities of monocyte subtypes between CD patients and HS group, these immunologic markers could be introduced as specific diagnostic biomarkers for CD.

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A Rare Concurrence of Hodgkin’s Lymphoma, Sickle Cell Disease and Diabetes Mellitus

Cited by 2 publications

References 0 publications

Epidemiology of cancer in Saudi Arabia thru 2010–2019: a systematic review with constrained meta-analysis<span style="font-size: 12px"> Running title: epidemiology of cancer in Saudi Arabia thru 2010–2019</span>

Epidemiology of cancer in Saudi Arabia thru 2010–2019: a systematic review with constrained meta-analysis<span style="font-size: 12px"> Running title: epidemiology of cancer in Saudi Arabia thru 2010–2019</span>

The expansion of CD14+ CD163+ subpopulation of monocytes and myeloid cells‐associated cytokine imbalance; candidate diagnostic biomarkers for celiac disease (CD)

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