A rare combination of acute myeloid leukemia with Vit B12 deficiency: Case report

Kitaz, Mohammad Nour; Zazo, Rama; Alsabbagh, Muhammad; Diabi, Muhammad; Alnahar, Salam; Chammout, Anwar

doi:10.1016/j.amsu.2022.104500

Cited by 2 publications

(1 citation statement)

References 18 publications

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“…Also, Vit B12 is formed by bacteria in the human colon 38 . Vitamin B12 is required for normal cell division, and its deficiency reasons many diseases such as macrocytic anemia, and megaloblastic anemia 39 .…”

Section: G1 G2 G3 G4mentioning

confidence: 99%

Ceruloplasmin and some biochemical parameters as a marker for acute myeloid leukemic patients

Mohsen,

Ali

2023

Tikrit J. Pure Sci.

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Acute myeloid leukemia is a second type of leukemia and has more effect on elder patients than adult. This research's objective was to measure the serum levels of ceruloplasmin (CP), ferritin (FR), vitamin B12 (VitB12), folic acid (FA), zinc (Zn), copper (Cu), and iron (Fe) in acute myeloid leukemic patients (AML) (before and after taking chemotherapy) and healthy control groups. In this study, about (160) blood samples (males and females) were collected from acute myeloid leukemic patients in Erbil’s Nanakali hospital and they were separated into four groups: Group 1 (G1) including (40) Apparently healthy control group, Group 2 (G2) include (40) acute myeloid leukemic patients before taking chemotherapy (new cases), Group 3 (G3) include (40) acute myeloid leukemia patients taking chemotherapy for one cycle, and Group 4 (G4) include (40) acute myeloid leukemic patients with taking chemotherapy for more than one cycle. The outcomes display a significant increase in serum concentration of ceruloplasmin, ferritin, vitamin B12, and iron in all patient groups when compared with control groups. While the serum concentration of folic acid, zinc, and copper decreased in all patient groups when compared with the healthy control group. In addition, the correlation analysis displays that there was a significant positive correlation between ceruloplasmin with ferritin, vitamin B12, and iron, on another hand have a non-significant negative correlation between ceruloplasmin with folic acid, zinc, and copper. According to the present study, there was a direct correlation between AML patients with the serum levels of CP, FR, VitB12, FA, Zn, Cu, and Fe. A high area under the curve of our data suggests that testing for (CP, FR, VitB12, FA, Cu, and Fe) could be helpful to detect AML. However, zinc is not a good biomarker for detecting AML patients.

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Section: G1 G2 G3 G4mentioning

confidence: 99%

Ceruloplasmin and some biochemical parameters as a marker for acute myeloid leukemic patients

Mohsen,

Ali

2023

Tikrit J. Pure Sci.

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Targeting the sulfur-containing amino acid pathway in leukemia

Chen,

Jin,

Chang

et al. 2024

Amino Acids

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Abstractsulfur-containing amino acids have been reported to patriciate in gene regulation, DNA methylation, protein synthesis and other physiological or pathological processes. In recent years, metabolism-related molecules of sulfur-containing amino acids affecting the occurrence, development and treatment of tumors have been implicated in various disorders, especially in leukemia. Here, we summarize current knowledge on the sulfur-containing amino acid metabolism pathway in leukemia and examine ongoing efforts to target this pathway, including treatment strategies targeting (a) sulfur-containing amino acids, (b) metabolites of sulfur-containing amino acids, and (c) enzymes and cofactors related to sulfur-containing amino acid metabolism in leukemia. Future leukemia therapy will likely involve innovative strategies targeting the sulfur-containing amino acid metabolism pathway.

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A rare combination of acute myeloid leukemia with Vit B12 deficiency: Case report

Cited by 2 publications

References 18 publications

Ceruloplasmin and some biochemical parameters as a marker for acute myeloid leukemic patients

Ceruloplasmin and some biochemical parameters as a marker for acute myeloid leukemic patients

Targeting the sulfur-containing amino acid pathway in leukemia

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