A Rare Clinical Entity: Staphylococcus-Related Glomerulonephritis

Abstract

Staphylococcus aureus is a rare cause of postinfectious glomerulonephritis, and Staphylococcus-related glomerulonephritis primarily occurs in middle-aged or elderly patients. Patients with Staphylococcus-related glomerulonephritis also present with hematuria, proteinuria of varying degrees, rising serum creatinine levels, and/or edema. The severity of renal insufficiency is proportional to the degree of proliferation and crescent formation. Here, we present a diabetic patient admitted with a history of 1 week of left elbow pain. Laboratory results revealed that erythrocyte sedimentation rate was 110 mm/hour, serum creatinine level was 1 mg/dL, C-reactive protein level was 150 mg/L, and magnetic resonance imaging showed signal changes in favor of osteomyelitis at the olecranon level, with diffuse edematous appearance in the elbow skin tissue and increased intra-articular effusion. After diagnosis of osteomyelitis, ampicillin/sulbactam and teicoplanin were administered. After day 7 of admission, the patient developed acute kidney injury requiring hemodialysis under antibiotic treatment. Kidney biopsy was performed to determine the underlying cause, which showed Staphylococcus-related glomerulonephritis. Recovery of renal func tions was observed after antibiotic and supportive treatment.

IgA dominant glomerulonephritis associated to staphylococcus infection: a peculiar case report

“…5 The prognosis of IgAdominantGN is less favorable than typical post infectious glomerulonephritis. 6,14 Hypertension, diabetes mellitus and fibrosis on kidney biopsy seem related to poor prognosis and deterioration of renal function. 1,4 In addition, this current case brings to the discussion the concept of an immune mediated response resulting from slow allocation bacteria that led to different organ lesions in different temporal settings.…”