A rare cause of small bowel perforation: A metastatic lesion from squamous cell carcinoma of the tongue

AlOmran, Hadeel; Albayyat, Layla S; AlMiman, Hisham; Boqari, Deena; AlDuhileb, Mohammed; Madkhali, Tariq

doi:10.1016/j.ijscr.2020.02.011

Cited by 4 publications

(5 citation statements)

References 9 publications

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“…Furthermore, the reference lists of relevant articles were thoroughly examined, and any additional pertinent works were added to the review. Overall, 17 cases that met the inclusion and exclusion criteria were identified, with this case report being the 18th (Table 1) [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22]. Of these reported cases, only six were identified as duodenal metastases, while the remaining cases consisted of eight ileal metastases, three While the pathophysiology of duodenal metastasis from HNSCC is not well understood, multiple mechanisms have been identified by which metastases can spread to the small intestine.…”

Section: Discussionmentioning

confidence: 99%

Squamous Cell Carcinoma of Duodenum Secondary to Metastasis From Recurrent Head and Neck Cancer: A Case Report and Literature Review

Zaw¹,

Zaw²,

Chen³

et al. 2023

Cureus

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This report describes a case involving the diagnosis and treatment of squamous cell carcinoma (SCC) of the duodenum, which was found to be a metastatic lesion originating from recurrent head and neck cancer (HNC) in a 74-year-old female patient. The patient had a past medical history of gastroesophageal reflux disease (GERD), tonsillar SCC, and recurrent HNC. She presented with symptoms of burning, tingling, and numbness of the throat and left side of the tongue. Upon examination with an esophagogastroduodenoscopy, an ulcerated hard area mass was detected in the third portion of the duodenum. Biopsy results confirmed the mass to be a metastatic poorly differentiated SCC. The incidence of head and neck squamous cell carcinoma (HNSCC) metastasis to the duodenum is rare, likely due to the unique anatomic location and the lack of lymphatic drainage in the area. The patient was treated with a combination of paclitaxel, carboplatin, and pembrolizumab. This case underscores the significance of considering unusual sites of metastasis in HNSCC patients and utilizing advanced imaging modalities and immunotherapy to detect and treat these locations effectively.

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Section: Discussionmentioning

confidence: 99%

Squamous Cell Carcinoma of Duodenum Secondary to Metastasis From Recurrent Head and Neck Cancer: A Case Report and Literature Review

Zaw¹,

Zaw²,

Chen³

et al. 2023

Cureus

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“…13 Metastases present primarily as obstructions but can also present as ileus, hemorrhage, bowel perforation, melena, and obstructive jaundice. [2][3][4][5][6][7][8][9][10][11]14 The initial evaluation of small bowel metastasis starts with CTs, magnetic resonance imagings, or PET scans. 3 Diagnosis is confirmed by obtaining pathology from upper endoscopy, enteroscopy, or exploratory laparotomy.…”

Section: Discussionmentioning

confidence: 99%

“…To date, there have been approximately 22 reported cases of head and neck cancers with metastasis to the bowel. [2][3][4][5][6][7][8][9][10][11]…”

Section: Introductionmentioning

confidence: 99%

Metastatic Head and Neck Squamous Cell Carcinoma Masquerading as Crohn's Disease

2022

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Metastasis from head and neck tumors to the small intestine is an extremely rare occurrence with a dismal prognosis. We present a 67-year-old man with metastatic head and neck squamous cell carcinoma that initially presented as recurrent small bowel obstruction and was misdiagnosed as Crohn's disease. On colonoscopy, terminal ileum biopsies of lymphoid-appearing subcentimeter nodules were positive for metastatic squamous cell cancer. Our case highlights the importance of having a high index of suspicion for metastasis in patients with a recent history of head and neck cancers.

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“…Other cancer types that metastasized to the SB in this study were not common and were presented elsewhere only as case reports. These cancers included breast cancer [12], colon cancer, cervical cancer [13], tongue squamous cell carcinoma [14], endometrial cancer [15], bladder urothelial cell carcinoma [16], renal cell carcinoma [17], gastric cancer [18], peripheral nerve sheath sarcoma [19], primary heart sarcoma [19], and pancreatic cancer [19].…”

Section: Discussionmentioning

confidence: 99%

Clinicopathology and Outcomes of Small Bowel Metastases: A Retrospective Study of 31 Consecutive Cases

Liao

Lin

et al. 2020

Preprint

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BACKGROUND The small bowel (SB) is a rare site for distant metastasis. Few recent studies have systematically reported on the clinicopathology and outcomes of SB metastasis. This study aimed to describe the clinicopathology and outcomes of SB metastasis. METHODS A retrospective study involving patients diagnosed with SB metastasis at a single medical center between January 2009 and December 2019 was conducted. Patients with secondary SB cancer with direct invasion or peritoneal carcinomatosis by a primary tumor were excluded. The demographic characteristics of the patients, clinical patterns of primary cancer and SB metastasis, and outcomes were analyzed. RESULTS During the 10-year period, we identified 31 patients eligible for analysis. The female:male ratio was 8:24, and the median patient age was 63.5 years. Metastasis of lung cancer to the SB was noted most frequently. Most patients presented with abdominal pain, gastrointestinal bleeding, or abnormal imaging findings. The interval between primary cancer and SB metastasis was 19.2 months. Sole SB metastasis was noted in 20 patients (64.5%). Twenty-two (70.1%) patients underwent surgical intervention. The median survival was 6.6 months. Conclusions Distant metastasis of other primary cancers to the SB is noted extremely rarely. The presence of SB metastasis indicated extremely poor prognosis. Surgery plays an important role in ameliorating critical symptoms However, surgery does not confer survival benefits.

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A rare cause of small bowel perforation: A metastatic lesion from squamous cell carcinoma of the tongue

Cited by 4 publications

References 9 publications

Squamous Cell Carcinoma of Duodenum Secondary to Metastasis From Recurrent Head and Neck Cancer: A Case Report and Literature Review

Squamous Cell Carcinoma of Duodenum Secondary to Metastasis From Recurrent Head and Neck Cancer: A Case Report and Literature Review

Metastatic Head and Neck Squamous Cell Carcinoma Masquerading as Crohn's Disease

Clinicopathology and Outcomes of Small Bowel Metastases: A Retrospective Study of 31 Consecutive Cases

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