A Rare Cause of Hypokalemia: Gitelman Syndrome

Abstract

Gitelman syndrome is a rare, inherited disorder. Hypokalemia, metabolic alkalosis, hypomagnesemia and

Gitelman's Syndrome: An unusual cause of Recurrent Attack of Quadriparesis

“…Causes of hypokalemia can be divided into four main categories; inadequate intake, GIT loss, renal loss, and excess potassium shift from extracellular to intracellular fluid. 2 As our patient was complaining neck pain, at first we excluded neck abnormalities by doing an X-ray and MRI of the neck. Both the investigations showed degenerative disc disease.…”

Persistent severe hypokalemia: Gitelman syndrome and differential diagnosis

“…New laboratory tests revealed: creatinine 1.26 mg/dl; magnesium 2.8 meq/L; sodium 130 meq/L; potassium 1.8 meq/L; chloride ur 80 mEq/L; calcium ur 29.2 mg/24h; magnesium ur 32.6 mg/24h; sodium ur 74 mmol/24h; potassium ur In the medical literature, there are only two case reports describing hypokalemic paralysis due to thyrotoxicosis accompanied by GS. One report in a 16-year-old Japanese male patient 13 and another, of a 35-year-old Indian male. 7 We have also found, two letters to the editor, describing four cases of Asian females with concurrent diagnosis of Grave's disease and GS.…”

“…11,12 It is mainly related to mutations in the SLC12A3 gene encoding for the thiazide-sensitive NaCl cotransporter of the distal convoluted tubule. 6,7,[11][12][13][14] In contrast to BS, GS is known to be characterized by more frequent hypomagnesemia and low urinary calcium excretion. 10 GS is very often asymptomatic.…”