A rare cause of goiter: Langerhans cell histiocytosis of the thyroid

Xia, Chenxi; Li, Rong; Wang, Zhihong; Lv, Fajin; Tang, Xiaoqiong; Li, Qifu; Zhang, Suhua

doi:10.1507/endocrj.ej11-0243

Cited by 18 publications

(21 citation statements)

References 28 publications

(28 reference statements)

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“…Los órganos más comprometidos en la histiocitosis de células de Langerhans en orden de mayor a menor compromiso son: pulmón, hipotálamo-pituitaria, piel, hueso, nódulos linfáticos, hígado, oído externo, tracto urinario, parótidas, timo y glándulas paratiroideas (12). En el sistema óseo el compromiso es mayor en los huesos planos y el esqueleto axial, sin embargo, también puede haber compromiso de huesos largos (cuadro 1).…”

Section: Discussionunclassified

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Histiocitosis de células de Langerhans e imágenes diagnósticas

Rosas-Saldarriaga¹,

Mesa-Mesa²,

Rosas-Michaelis³

2016

CES Med

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Comparte ResumenEl objetivo del artículo es presentar el caso de un paciente que consultó al servicio de imaginología por dolor en la región costal, y quien posteriormente fue diagnosticado como histiocitosis de células de Langerhans. Se pretende proveer al lector una breve revisión de tema de imágenes diagnósticas de esta enfermedad para que el reconocimiento de la misma permanezca dentro de la lista de diagnósticos diferenciales.Palabras clave: Histiocitosis, Células de Langerhans, Imagenología. AbstractThe goal of this article is to provide readers with a case presentation of a patient who presented to the radiology department for pain located at the costal region, which later was diagnosed as Langerhans cell histiocytosis (LCH). We pretend with this article to provide a brief, complete and efficient literature review regarding the topic of imaging on this pathology. This was done with the objective of providing the reader with a brief and concise literature review so that this disease entity can remain within the list of differencials. Keywords: Histiocytosis, Langerhans cells, Imaginology Caso clínicoAl departamento de imagenología se presentó un paciente masculino de cincuenta años de edad, conductor de un camión transportador, habitante en zona urbana, sin antecedentes personales o familiares de neoplasias, enfermedades congénitas ni de otro tipo de enfermedades de importancia. El paciente venía remitido por el especialista en oncología por un cuadro clínico de varios meses de evolución consistente en dolor inespecífico en la región del hemitórax derecho, que no presentaba ningún tipo de patrón de origen cardíaco, respiratorio, neuropático, irradiado o de serosas.Se decidió realizar una resonancia magnética nuclear para evaluar posibles etiologías de la sintomatología. La lectura de este estudio identificó fracturas en proceso de consolidación en los arcos laterales derechos, de la cuarta y quinta costilla, asociadas a edema de tejidos blandos alrededor de la lesión. Adicionalmente, el paciente presentaba un hemangioma atípi-co en la región central derecha del cuerpo vertebral T8.

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Section: Discussionunclassified

“…Debe realizarse un análisis histopatológico usando marcadores de inmunohistoquímica como son el CD-1a y el S-100 (9,10,12).…”

Section: Biopsiaunclassified

Histiocitosis de células de Langerhans e imágenes diagnósticas

Rosas-Saldarriaga¹,

Mesa-Mesa²,

Rosas-Michaelis³

2016

CES Med

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“…Compared with pituitary involvement, thyroid LCH is much more rare, happening more in adults than in children (5,16). Thyroid LCH usually presents with diffuse or nodular thyroid enlargement (16,17), while thyroidal pain and obstructive symptoms are unusual (16). Thyroid function may be euthyroid or hypothyroid (18), and some cases may have abnormal increase in the levels of TgAb and TMAb (16).…”

Section: Discussionmentioning

confidence: 99%

Langerhans Cell Histiocytosis Presenting as Endocrine Disorders in an Adult Patient: A Case Report

Yan

Jing²,

Wang³

et al. 2015

AACE Clinical Case Reports

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Objective: To present a case of Langerhans cell histiocytosis (LCH) involving the pituitary and thyroid that was misdiagnosed as idiopathic diabetes insipidus (DI) and Hashimoto thyroiditis. Methods: The history, clinical findings, laboratory and imaging results, management, and follow-up of the case are presented, and the endocrine involvement is discussed. Results: A 50-year-old female with a 13-year history of DI and a 5-year history of progressive goiter with hypothyroidism had been initially diagnosed with idiopathic DI and Hashimoto thyroiditis. She also had a 10-year history of diabetes mellitus (DM). A partial thyroidectomy was conducted when the goiter caused dyspnea, and the postoperative pathological results suggested LCH. After a thorough examination, the diagnosis of LCH was confirmed, and the patient was treated with chemotherapy and radiotherapy. After the treatment, she went into persistent remission. Conclusion: LCH cases mainly presenting as endocrine disorders are very rare, and the diagnosis tends to be delayed or missed due to atypical clinical manifestations. Lesions or functional disorders of the pituitary and thyroid need to be differentially diagnosed against LCH of these organs. Appropriate therapy and long-term follow-up are necessary for the management of endocrine LCH. (AACE Clinical Case Rep. 2015;1:e199-e203) Abbreviations: CT = computed tomography; DI = diabetes insipidus; DM = diabetes mellitus; LCH = Langerhans cell histiocytosis; MRI = magnetic resonance imaging; TSH = thyroid-stimulating hormone

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“…Tanı aldıktan 1 sene sonra olguda diabetes insipitus tablosu gelişmiş ve kanda ADH yüksekliği saptanmıştır Yapılan hipofiz magnetik rezonans görüntülemede kitle saptanmamıştır. Posterior hipofiz bezi çoklu sistem tutulumlu olguların %50' sinden fazlasında görülmektedir, diabetes insipitus tablosu ile karakterizedir 6 . Hastanın yaşı, tutulan organ sayısı, tutulan organların foksiyon görüp görmemesi ve tedaviye cevap prognostik parametrelerdir.…”

Section: Resim 3 Langerin Pozitifliği Langerin X200unclassified