A Rare Cause of Cardiomyopathy: A Case of Selenium Deficiency Causing Severe Cardiomyopathy that Improved on Supplementation

Munguti, Cyrus; Rifai, Mahmoud Al; Shaheen, Wassim

doi:10.7759/cureus.1627

Cited by 6 publications

(6 citation statements)

References 8 publications

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“…Further strengthening the argument that Se is important in cardiovascular function is that Se deficiency also contributes to the pathogenesis of other cardiomyopathies and heart failure. A recently reported rare case of dilated cardiomyopathy in a young boy was attributed to chronic starvation and a severe Se deficiency [ 27 ]. Notably, nutritional support with Se supplementation resulted in the reversal of the disease.…”

Section: The Relationship Between Se Deficiency and Cardiovascular Healthmentioning

confidence: 99%

“…Clinically, low Se levels are associated with higher rates of all-cause mortality due to heart failure [ 4 ], increased rates of myocardial infarction [ 5 ], and cardiomyopathies [ 27 , 93 ]. It is therefore unsurprising that several studies have focused on Se supplementation to mitigate cardiovascular disease despite mixed results, likely due to a host of factors, including the different pharmacokinetics of various forms of Se, the range and duration of treatment, and whether Se was used alone or in combination with another therapy.…”

Section: Se Supplementation For Mitigation Of Cardiovascular Diseasesmentioning

confidence: 99%

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The Impact of Selenium Deficiency on Cardiovascular Function

Shimada

Alfulaij

Seale

2021

IJMS

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Selenium (Se) is an essential trace element that is necessary for various metabolic processes, including protection against oxidative stress, and proper cardiovascular function. The role of Se in cardiovascular health is generally agreed upon to be essential yet not much has been defined in terms of specific functions. Se deficiency was first associated with Keshan’s Disease, an endemic disease characterized by cardiomyopathy and heart failure. Since then, Se deficiency has been associated with multiple cardiovascular diseases, including myocardial infarction, heart failure, coronary heart disease, and atherosclerosis. Se, through its incorporation into selenoproteins, is vital to maintain optimal cardiovascular health, as selenoproteins are involved in numerous crucial processes, including oxidative stress, redox regulation, thyroid hormone metabolism, and calcium flux, and inadequate Se may disrupt these processes. The present review aims to highlight the importance of Se in cardiovascular health, provide updated information on specific selenoproteins that are prominent for proper cardiovascular function, including how these proteins interact with microRNAs, and discuss the possibility of Se as a potential complemental therapy for prevention or treatment of cardiovascular disease.

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Section: The Relationship Between Se Deficiency and Cardiovascular Healthmentioning

confidence: 99%

Section: Se Supplementation For Mitigation Of Cardiovascular Diseasesmentioning

confidence: 99%

The Impact of Selenium Deficiency on Cardiovascular Function

Shimada

Alfulaij

Seale

2021

IJMS

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“…Growth hormone disorders, pheochromocytoma, and Cushing's disease are also very rare causes of DCM [26,46]. Furthermore, the literature names nutritional deficiencies of thiamine (beriberi disease), selenium (Keshan disease), and l-carnitine being responsible for DCM [47,48].…”

Section: Endocrine/metabolic Disordersmentioning

confidence: 99%

Current Pathophysiological and Genetic Aspects of Dilated Cardiomyopathy

Schild¹,

Ricciardi²,

Hellige³

et al. 2019

Visions of Cardiomyocyte - Fundamental Concepts of Heart Life and Disease [Working Title]

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Dilated cardiomyopathy is the most common form of cardiomyopathy and the second leading cause of left ventricular dysfunction with highly variable clinical presentation and prognosis. The clinical courses vary and are strongly heterogeneous, ranging from asymptomatic patients to those suffering from intractable heart failure or sudden cardiac death due to arrhythmias. Previous studies have reported a 10 years cardiovascular mortality up to 40% in developed countries, due to advanced heart failure or sudden cardiac death. However, the prognosis of dilated cardiomyopathy patients is variable and depends on multiple risk factors. This chapter provides a review of dilated cardiomyopathy with specific focus on the pathophysiological aspects and genetic etiology of the disease.

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“…The obvious changes in food Si content [22] could have been similar by pigs and humans, but Se availability was remarkably lower by humans before the beginning of Se fertilization in the 1980's [12]. In human medicine Se is not included in general cardiac medicines [30]. HeD.a-% is a better measure of mortality, than morbidity.…”

Section: Seleniummentioning

confidence: 99%

Human CHD and Pig Cardiac Mortality in Finland during 1954-86

Töysä¹

2018

BJSTR

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Introduction: Environmental factors affect on foodstuff quality. Because pigs and humans eat same foodstuffs (cereals, potatoes and dairy products) we could expect that time-related changes in them could show simultaneous health changes in both of them. In this study are assayed female (F) and male (M) mortality changes in coronary heart disease (CHD) and their associations with pig autopsy parameters. Data are presented from period 1951-2000, statistically analyzed from period 1954-86 including autopsy density per 100,000 pigs [A.1/100,000], autopsy percents of microangiopathy [MAP.a-%] and cardiovascular diagnoses total [CVD.tot.a-%], additionally visually analyzed myocardial degeneration, Hepatosis diaetetica [HeD.a-%] and skeletal muscle degeneration [SMuD.a-%].

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A Rare Cause of Cardiomyopathy: A Case of Selenium Deficiency Causing Severe Cardiomyopathy that Improved on Supplementation

Cited by 6 publications

References 8 publications

The Impact of Selenium Deficiency on Cardiovascular Function

The Impact of Selenium Deficiency on Cardiovascular Function

Current Pathophysiological and Genetic Aspects of Dilated Cardiomyopathy

Human CHD and Pig Cardiac Mortality in Finland during 1954-86

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