Purpura Fulminans (PF) is a disease that occurs after septicemia. It has a rapid course. PF causes disseminated intravascular coagulation and severe organ failure. Extremity amputation and fatality rates are very high, even if it is diagnosed and treated promptly. This case report presented a 59-year-old man who developed purpura fulminans after Endoscopic Retrograde Cholangiopancreatography (ERCP).