A rare case with prominent features of both discoid lupus erythematosus and pemphigus foliaceus

Temel, Aslı Bilgiç; Ergun, Erkan; Poot, Andreas A.; Başsorgun, Cumhur İ̇brahim; Akman-Karakaş, Ayşe; Uzun, Soner; Alpsoy, Erkan; Pas, Hendrikus; Jonkman, Marcel F.

doi:10.1111/jdv.15099

Cited by 4 publications

(6 citation statements)

References 6 publications

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“…Sawamura et al reported a case of SLE with PF, myasthenia gravis, and chronic thyroiditis after a thymectomy for thymoma, which are rare coexisting autoimmune diseases 7. A recent report by Temel et al demonstrated an unusual case with prominent features of both DLE and PF 66. PV has also been reported to coexist with LE 6,65,67–69.…”

Section: Le-aspecific Vesiculobullous Diseasesmentioning

confidence: 99%

“…Patients with PE have been documented to have internal lupus (ie, hematologic renal involvement) 71. A few reported cases of PF coexisting with LE have been published 7,66. Sawamura et al reported a case of SLE with PF, myasthenia gravis, and chronic thyroiditis after a thymectomy for thymoma, which are rare coexisting autoimmune diseases 7.…”

Section: Le-aspecific Vesiculobullous Diseasesmentioning

confidence: 99%

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<p>Vesiculobullous diseases in relation to lupus erythematosus</p>

Rutnin

Chanprapaph

2019

CCID

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Vesiculobullous lesions in lupus erythematosus (LE) are a rare cutaneous manifestation of cutaneous and/or systemic LE with variable presentation. While the minor forms of LE-associated vesiculobullous disease may cause disfigurement and discomfort, the severe forms can present with hyperacute reaction and life-threatening consequences. Specific LE and aspecific cutaneous LE are defined by the presence or absence of interface change on histopathology that can be applied to vesiculobullous diseases in relation to LE. However, the diagnosis of LE-associated vesiculobullous diseases remains difficult, due to the poorly defined nosology and the similarities in clinical and immunohistopathological features among them. Herein, we thoroughly review the topic of vesiculobullous skin disorders that can be encountered in LE patients and organize them into four groups: LE-specific and aspecific vesiculobullous diseases, LE-related autoimmune bullous diseases, and LE in association to non-autoimmune conditions. We sought to provide an updated overview highlighting the pathogenesis, clinical, histological, and immunopathological features, laboratory findings, and treatments and prognosis among vesiculobullous conditions in LE.

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Section: Le-aspecific Vesiculobullous Diseasesmentioning

confidence: 99%

Section: Le-aspecific Vesiculobullous Diseasesmentioning

confidence: 99%

<p>Vesiculobullous diseases in relation to lupus erythematosus</p>

Rutnin

Chanprapaph

2019

CCID

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“…1 Many forms of pemphigus have been anecdotally reported to occur in association with LE as well as other autoimmune diseases, but the pathogenic mechanism remains unclear. [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] Previous reports have demonstrated cases with pemphigus foliaceus (PF) or pemphigus vulgaris (PV) in association to discoid lupus erythematosus (DLE). 11,12 To date, there has been only one reported case of paraneoplastic pemphigus (PNP) associated with SLE.…”

Section: Introductionmentioning

confidence: 99%

“…[2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] Previous reports have demonstrated cases with pemphigus foliaceus (PF) or pemphigus vulgaris (PV) in association to discoid lupus erythematosus (DLE). 11,12 To date, there has been only one reported case of paraneoplastic pemphigus (PNP) associated with SLE. 3 To the best of our knowledge, we present the first case of DLE and PNP associated with marginal zone lymphoma.…”

Section: Introductionmentioning

confidence: 99%

Coexistence of Discoid Lupus Erythematosus and Paraneoplastic Pemphigus: A Case Report and Literature Review

Saowaluksakul¹,

Seree-aphinan²,

Rutnin³

et al. 2022

CCID

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Pemphigus and lupus erythematosus are both B-cell-mediated autoimmune diseases, dependent on autoreactive CD4+ T lymphocytes to modulate autoimmune B-cell response. Many forms of pemphigus have been reported to occur in association with systemic lupus erythematosus (SLE) as well as other autoimmune diseases. However, it remains unclear whether this association occurs because of a shared immunopathogenesis or the coexistence may be coincidental. We hereby present a case report of discoid lupus erythematosus and paraneoplastic pemphigus associated with marginal zone lymphoma in a 54-year-old Thai man who had persistent oral erosions for 1 year together with generalized polymorphic cutaneous eruptions for 2 months. Simultaneous occurrence of paraneoplastic pemphigus and discoid lupus erythematosus without SLE has never been reported in the same individual. Hydroxychloroquine, immunosuppressive agents including prednisolone and azathioprine together with chemotherapy were given to treat these conditions.

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“…For example, we reported recently two dogs with poly-autoimmunity presented with comorbid PF and generalized cutaneous lupus erythematosus [ 125 ]. The co-occurrence of PF and discoid lupus erythematosus (DLE) occurs rarely in humans, and this is to be differentiated from pemphigus erythematosus (PE), which is a mild, facial form of PF with lesions clinically, but not histologically, resembling a DLE-associated malar rash [ 3 , 126 ]. In veterinary medicine, PE is considered a pustular, erosive, and crusting disease of the face with clinical and histological features of PF and DLE [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Deep pemphigus (pemphigus vulgaris, pemphigus vegetans and paraneoplastic pemphigus) in dogs, cats and horses: a comprehensive review

2020

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Pemphigus is the term used to describe a group of rare mucocutaneous autoimmune bullous diseases characterized by flaccid blisters and erosions of the mucous membranes and/or skin. When the autoantibodies target desmosomes in the deep layers of the epidermis, deep pemphigus variants such as pemphigus vulgaris, pemphigus vegetans and paraneoplastic pemphigus develop. In this article, we will review the signalment, clinical signs, histopathology and treatment outcome of pemphigus vulgaris, pemphigus vegetans and paraneoplastic pemphigus in dogs, cats and horses; where pertinent, we compare the animal diseases to their human homologue. Canine, feline and equine pemphigus vulgaris, pemphigus vegetans and paraneoplastic pemphigus have many features similar to the human counterpart. These chronic and often relapsing autoimmune dermatoses require aggressive immunosuppressive therapy. In animals, the partial-to-complete remission of pemphigus vulgaris and pemphigus vegetans has been achieved with high dose glucocorticoid therapy, with or without adjunct immunosuppressants; the prognosis is grave for paraneoplastic pemphigus.

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A rare case with prominent features of both discoid lupus erythematosus and pemphigus foliaceus

Cited by 4 publications

References 6 publications

<p>Vesiculobullous diseases in relation to lupus erythematosus</p>

<p>Vesiculobullous diseases in relation to lupus erythematosus</p>

Coexistence of Discoid Lupus Erythematosus and Paraneoplastic Pemphigus: A Case Report and Literature Review

Deep pemphigus (pemphigus vulgaris, pemphigus vegetans and paraneoplastic pemphigus) in dogs, cats and horses: a comprehensive review

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