A Rare Case Report of Subcutaneous Phaeohyphomycotic Cyst Caused by Exophiala oligosperma in an Immunocompetent Host with Literature Review

Venkateshwar, Sithara; Ambroise, Marie Moses; Asir, G. Johny; Mudhigeti, Nagaraja; Ramdas, Anita; K, Authy; Shivaprakash, M. R.; Kanungo, Reba

doi:10.1007/s11046-014-9762-4

Cited by 13 publications

(7 citation statements)

References 24 publications

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“…Several members of the genus Exophiala are potential agents of human and animal mycoses and for that are considered to be in the Bio Safety Level-2 (BSL-2) group. In this study, together with E. xenobiotica, we found other species associated with clinical cases, including E. oligosperma a sporadic agent of phaeohyphomycosis [81,82], E. phaeomuriformis mentioned in relation to keratitis [83], Rhinocladiella similis recently found in a nosocomial infection [84], and Knufia epidermidis associated with mild skin infections [85].…”

Section: Discussionmentioning

confidence: 50%

Hydrocarbon-Contaminated Sites: Is There Something More Than Exophiala xenobiotica? New Insights into Black Fungal Diversity Using the Long Cold Incubation Method

Isola

Scano

Orrù

et al. 2021

JoF

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Human-made hydrocarbon-rich environments are important reservoirs of microorganisms with specific degrading abilities and pathogenic potential. In particular, black fungi are of great interest, but their presence in the environment is frequently underestimated because they are difficult to isolate. In the frame of a biodiversity study from fuel-contaminated sites involving 30 diesel car tanks and 112 fuel pump dispensers (52 diesel and 60 gasoline, respectively), a total of 181 black fungal strains were isolated. The long cold incubation (LCI) of water-suspended samples, followed by plating on Dichloran Rose Bengal Chloramphenicol Agar (DRBC), gave isolation yields up to six times (6.6) higher than those of direct plating on DRBC, and those of enrichment with a phenolic mix. The sequencing of ITS and LSU-rDNA confirmed the dominance of potentially pathogenic fungi from the family Herpotrichiellaceae and Exophiala xenobiotica. Moreover, other opportunistic species were found, including E. opportunistica, E. oligosperma, E. phaeomuriformis, and Rhinocladiella similis. The recurrent presence of E. crusticola, Knufia epidermidis, Aureobasidium melanogenum, Cladosporium spp., and Scolecobasidium spp. was also recorded. Interestingly, 12% of total isolates, corresponding to 50% of taxa found (16/32), represent new species. All the novel taxa in this study were isolated by LCI. These findings suggest that black fungal diversity in hydrocarbon-rich niches remains largely unexplored and that LCI can be an efficient tool for further investigations.

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Section: Discussionmentioning

confidence: 50%

Hydrocarbon-Contaminated Sites: Is There Something More Than Exophiala xenobiotica? New Insights into Black Fungal Diversity Using the Long Cold Incubation Method

Isola

Scano

Orrù

et al. 2021

JoF

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“…Various dematiaceous fungi have been reported from phaeohyphomycotic cysts. Various unusual fungal agents such as Phialemoniopsis ocularis [10], Phaeoacremonium inflatipes [11], Exophiala oligosperma [12], Exophiala spinifera [13], Medicopsis romeroi (Pyrenochaeta romeroi) [14,15] are the reported from of subcutaneous phaeohyphomycosis.…”

Section: Discussionmentioning

confidence: 99%

Subcutaneous Cyst Due to a Novel Fungus, Aquastroma magniostiolata: A Case Report

Keche¹,

Ramchandani²,

Gupta³

et al. 2022

Cureus

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Various kinds of fungal agents have been observed in the environment. Fungi can enter the human body by penetration following trauma and are responsible for various types of subcutaneous mycotic lesions. In this case report, we present the case of a 47-year-old female patient who presented with swelling on the lateral aspect of the left lower leg above the lateral malleolus. Aspirate from the site was sent for histopathological examination for detection of the fungus. After microbiological investigation, a rare fungus isolated in this patient was identified as Aquastroma magniostiolata by carrying out sequencing at a reference center.

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“…Phylogenetic analyses placed E. campbellii in the E. dermatitidis clade, which contains most of the recognised human pathogenic species, and suggested that E. campbellii was most closely related to E. oligosperma [ 5 ]. E. oligosperma is a rare, but known cause of subcutaneous fungal infections, having previously been reported from solitary mycotic cysts and more disseminated subcutaneous phaeohyphomycosis in both immunocompetent and compromised patients [ [15] , [16] , [17] , [18] , [19] ].…”

Section: Discussionmentioning

confidence: 99%

Exophiala campbellii causing a subcutaneous palmar cyst in an otherwise healthy UK resident

Borman

Fraser

Schilling

et al. 2020

Medical Mycology Case Reports

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Exophiala is a ubiquitous genus encompassing more than forty species, a number of which have been associated with superficial or systemic infections in humans, and other hot- or cold-blooded animals. Here we report a human case of subcutaneous mycotic cyst caused by Exophiala campbellii . To our knowledge, this is only the third reported human infection caused by E. campbellii , all three of which involved subcutaneous nodules in patients who had resided in the United Kingdom.

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A Rare Case Report of Subcutaneous Phaeohyphomycotic Cyst Caused by Exophiala oligosperma in an Immunocompetent Host with Literature Review

Cited by 13 publications

References 24 publications

Hydrocarbon-Contaminated Sites: Is There Something More Than Exophiala xenobiotica? New Insights into Black Fungal Diversity Using the Long Cold Incubation Method

Hydrocarbon-Contaminated Sites: Is There Something More Than Exophiala xenobiotica? New Insights into Black Fungal Diversity Using the Long Cold Incubation Method

Subcutaneous Cyst Due to a Novel Fungus, Aquastroma magniostiolata: A Case Report

Exophiala campbellii causing a subcutaneous palmar cyst in an otherwise healthy UK resident

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