Abstract:Limited number of cases has been reported in the literature regarding spontaneous teeth exfoliation secondary to herpes zoster. The exact pathogenesis regarding the spontaneous exfoliation of teeth in herpes zoster patient is still controversial. Thus, an oral health care provider should be aware of this rare complication while managing a case of tooth mobility with the previous history of herpes zoster of trigeminal nerve.
“…The V1 and V2 branches innervate the eye and upper face (Leiser and Moxon, 2006 ). The trigeminal nerve is the most common cranial nerve involved in zoster of the face followed by the glossopharyngeal and hypoglossal nerves (Kaur et al, 2016 ). Regions of the face innervated by the V1 branch of the trigeminal ganglion are the most common in presenting zoster and regions innervated by V2 and V3 are less commonly involved in HZ of the face (Millar and Troulis, 1994 ) thus, we targeted the more commonly infected neurons of the trigeminal ganglion in these studies.…”
Varicella zoster virus (VZV) infects the face and can result in chronic, debilitating pain. The mechanism for this pain is unknown and current treatment is often not effective, thus investigations into the pain pathway become vital. Pain itself is multidimensional, consisting of sensory and affective experiences. One of the primary brain substrates for transmitting sensory signals in the face is the ventral posterior medial/posterior lateral thalamus (VPM/VPL). In addition, the anterior cingulate cortex (ACC) has been shown to be vital in the affective experience of pain, so investigating both of these areas in freely behaving animals was completed to address the role of the brain in VZV-induced pain. Our lab has developed a place escape avoidance paradigm (PEAP) to measure VZV-induced affective pain in the orofacial region of the rat. Using this assay as a measure of the affective pain experience a significant response was observed after VZV injection into the whisker pad and after VZV infusion into the trigeminal ganglion. Local field potentials (LFPs) are the summed electrical current from a group of neurons. LFP in both the VPM/VPL and ACC was attenuated in VZV injected rats after inhibition of neuronal activity. This inhibition of VPM/VPL neurons was accomplished using a designer receptor exclusively activated by a designer drug (DREADD). Immunostaining showed that cells within the VPM/VPL expressed thalamic glutamatergic vesicle transporter-2, NeuN and DREADD suggesting inhibition occurred primarily in excitable neurons. From these results we conclude: (1) that VZV associated pain does not involve a mechanism exclusive to the peripheral nerve terminals, and (2) can be controlled, in part, by excitatory neurons within the VPM/VPL that potentially modulate the affective experience by altering activity in the ACC.
“…The V1 and V2 branches innervate the eye and upper face (Leiser and Moxon, 2006 ). The trigeminal nerve is the most common cranial nerve involved in zoster of the face followed by the glossopharyngeal and hypoglossal nerves (Kaur et al, 2016 ). Regions of the face innervated by the V1 branch of the trigeminal ganglion are the most common in presenting zoster and regions innervated by V2 and V3 are less commonly involved in HZ of the face (Millar and Troulis, 1994 ) thus, we targeted the more commonly infected neurons of the trigeminal ganglion in these studies.…”
Varicella zoster virus (VZV) infects the face and can result in chronic, debilitating pain. The mechanism for this pain is unknown and current treatment is often not effective, thus investigations into the pain pathway become vital. Pain itself is multidimensional, consisting of sensory and affective experiences. One of the primary brain substrates for transmitting sensory signals in the face is the ventral posterior medial/posterior lateral thalamus (VPM/VPL). In addition, the anterior cingulate cortex (ACC) has been shown to be vital in the affective experience of pain, so investigating both of these areas in freely behaving animals was completed to address the role of the brain in VZV-induced pain. Our lab has developed a place escape avoidance paradigm (PEAP) to measure VZV-induced affective pain in the orofacial region of the rat. Using this assay as a measure of the affective pain experience a significant response was observed after VZV injection into the whisker pad and after VZV infusion into the trigeminal ganglion. Local field potentials (LFPs) are the summed electrical current from a group of neurons. LFP in both the VPM/VPL and ACC was attenuated in VZV injected rats after inhibition of neuronal activity. This inhibition of VPM/VPL neurons was accomplished using a designer receptor exclusively activated by a designer drug (DREADD). Immunostaining showed that cells within the VPM/VPL expressed thalamic glutamatergic vesicle transporter-2, NeuN and DREADD suggesting inhibition occurred primarily in excitable neurons. From these results we conclude: (1) that VZV associated pain does not involve a mechanism exclusive to the peripheral nerve terminals, and (2) can be controlled, in part, by excitatory neurons within the VPM/VPL that potentially modulate the affective experience by altering activity in the ACC.
“…HZ is a characteristic disease of the elderly; individuals over 60 are 8 to 10 times more likely to develop the disease than those under 60 5 . In addition to age, people in an immunosuppressive state, such as bone marrow transplant recipients and HIV-positive patients are also at risk 2,5,10 . Some authors recommend that, regardless of the concomitant presence of other risk factors, all patients with herpes zoster should be tested for HIV 3 .…”
Section: Discussionmentioning
confidence: 99%
“…Among the cranial nerves involved by HZ infection, the trigeminal nerve is the most affected, with the ophthalmic branch being the most commonly involved 2,10 . The facial and vestibule-cochlear nerves are, respectively, the second and third cranial nerves most affected.…”
Section: Discussionmentioning
confidence: 99%
“…The facial and vestibule-cochlear nerves are, respectively, the second and third cranial nerves most affected. 10 The clinical characteristics of patients with HZ can evolve in three stages: prodromal, active and chronic 1,2,11 . In the first, symptoms such as pain, tingling and itching of the skin, on the distribution of the affected nerve, usually precede the rash, present in the active stage, for a few hours or several days 2 .…”
Section: Discussionmentioning
confidence: 99%
“…Varicella-zoster (VZV) is a virus that belongs to the Herpesvirus family, which can cause two different clinical infections: a primary infection, varicella and secondary or recurrent, or herpes zoster (HZ) 1,2 . After chickenpox is resolved, the virus remains latent in the dorsal root ganglia, and may, at some point, reactivate and trigger herpes zoster [2][3][4] .…”
Herpes Zoster is an acute, self-limiting, viral infection caused by the reactivation of the Varicella Zoster Virus (VZV) that remains latent in the dorsal root ganglion. It commonly affects the older people and immunocompromised individuals. Diabetes patients present an increased risk for Herpes Zoster due to their impaired cell-mediated immunity. Clinically it manifests with tingling, pruritus and painful vesicular eruptions along the affected nerve. The most commonly affected dermatomes are the thoracic and lumbar; trigeminal nerve can be involved and the ophtalmic nerve is the mostly affected. The diagnosis is based on clinical examination and laboratory confirmation. Treatment consists of antiviral therapy and is indicated to reduce acute pain symptoms, limit the spread and duration of the lesions, and prevent complications. The objective of the present study was to present a case report of Herpes Zoster involving the first and second division of the trigeminal nerve, in a 55 year old, male, diabetes patient.
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