A rare case of urinary tract infection with burkholderia cepacia in a male child

Armean, Iulia; Meliţ, Lorena Elena

doi:10.37897/rjid.2018.2.3

Cited by 1 publication

(1 citation statement)

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“…UTI is defined as a significant bacteriuria growth of a single pathogen: At least 10 4 colony forming units (CFU) for catheter specimens and at least 10 5 CFU for midstream clean catch specimens) or 5x10 4 CFU and significant pyuria in a patient with fever or other clinical symptoms (5)(6)(7)(8)(9). Recurrent UTIs are defined as repeated infections with a different pathogen agent, while relapsing UTIs represent repeated infections with the same pathogen (5)(6)(7)10,11).…”

Section: Introductionmentioning

confidence: 99%

Antibiotic resistance patterns of urinary tract pathogens in children from Central Romania

Duicu

Cozea²,

Delean

et al. 2021

Exp Ther Med

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One of the most frequent bacterial infections in children are urinary tract infections (UTIs). In recent years, an increasing incidence of UTIs caused by resistant bacterial strains has been observed, especially with extended-spectrum β-lactamase-producing Enterobacteriaceae that represent about 15% of UTIs. A retrospective study was performed comprising 331 pediatric cases with UTI. Our study aimed to detect the resistance of the uropathogens to common drugs used in UTI treatment. High resistance rates have been recorded for ampicillin, amoxicillin, trimethoprim/sulfamethoxazole (TMP/SMX), cefuroxime, and ciprofloxacin, among E. coli and Klebsiella. The multidrug-resistance (MDR) rate was detected in one-third of the uropathogens, among which more than half were isolated in patients with urinary tract abnormalities. Our study highlighted that nitrofurantoin, ceftriaxone, amikacin and carbapenem may be used for the empirical treatment for febrile or complicated UTI in children. This is the first comprehensive study that evaluates antibiotic resistance in UTIs in children, and their association with urinary tract abnormalities in Romania. As a result of this research, the protocol for initial empiric treatment of infants with febrile or complicated UTI should be modified considering a detailed and ongoing monitoring of local sensitivity of uropathogens to antimicrobial agents.

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