A rare case of tuberculosis-induced hypercalcemia

Wauthier, Loris; Theunssens, X.; Durez, Patrick; Fillée, Catherine; Maisin, Diane; Gruson, Damien

doi:10.11613/bm.2020.030801

Cited by 4 publications

(2 citation statements)

References 15 publications

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“…TB is one of the granulomatous diseases that alter the status of the plasma concentration of serum calcium [38]. While some studies report TB-associated hypercalcemia [39,40], others report hypocalcemia [41,42]. In the present study, most TB patients (88.9%) presented hypocalcemia, while 5.55% had hypercalcemia.…”

Section: Discussionsupporting

confidence: 46%

Clinical Features, Biochemical Parameters, and Treatment Adherence of Individuals Who Started the Treatment for Active Pulmonary Tuberculosis during the Pandemic Period

Sales

Lopes

Vale

et al. 2023

JCM

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This descriptive prospective study investigated the clinical features and treatment adherence of individuals who started the treatment for Pulmonary tuberculosis (TB) during the COVID-19 pandemic in São Luís. Thirty-six TB patients and thirty-five age/sex-matched individuals were recruited between January 2021 and January 2022. The clinical features, sociodemographic information, and serum were obtained at the diagnosis time. Adherence to treatment and adverse reactions were investigated monthly. The most common symptoms in TB patients were cough (91.6%) and fever (83.3%). All TB patients had elevated pre-therapy levels of CRP and reduced HDL: 88.9% presented hypocalcemia and 47.2% showed elevated ALP and GGT. TB patients showed higher levels of ALT, AST, ALP, GGT, CRP, amylase, and triglycerides than the comparison group (p < 0.05), while the calcium levels were reduced (p < 0.0001). TB patients with anti-SARS-CoV-2-IgG antibodies (seroprevalence of 66.7%) presented higher values of amylase and lower CRP levels (p < 0.05). Most patients (~70%) reported at least one adverse drug reaction, mainly pruritus and nausea. The treatment abandonment rate was 19.2%. In conclusion, TB patients showed elevated pre-therapy levels of CRP, low levels of HDL, and hypocalcemia. Liver and pancreatic functions were also compromised in several patients before the therapy. The treatment non-adherence rate observed was similar to other studies performed before the pandemic period.

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Section: Discussionsupporting

confidence: 46%

Clinical Features, Biochemical Parameters, and Treatment Adherence of Individuals Who Started the Treatment for Active Pulmonary Tuberculosis during the Pandemic Period

Sales

Lopes

Vale

et al. 2023

JCM

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“…Our report revealed elevated calcitriol levels and normal 25-(OH) Vitamin D levels. Wauthier L et al [10] offered a similar interpretation and described an exceptional occurrence of hypercalcemia in the context of disseminated TB in a patient with rheumatoid arthritis. A stimulated 1-hydroxylase activity of the macrophages within the granulomatous response sites of tuberculosis patients can be the cause of this rise in calcitriol concentrations.…”

Section: Discussionmentioning

confidence: 82%

Rare Presentation of Disseminated Tuberculosis in the Present Era of Modern Tuberculosis Management

Anilkumar

Manikandan

Sreenivasan³

2022

IJMPCR

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Background: Disseminated tuberculosis (TB) is defined as two or more noncontiguous sites resulting from lymphohematogenous dissemination of Mycobacterium tuberculosis. In an immunocompetent host, it is uncommon. The presentation varies, and non-specific early infection symptoms can be noted on chest radiography. Early medication beginning is linked to significantly better outcomes in cases of disseminated tuberculosis. The current case report describes the series of incidents that resulted from a 50-year-old man's excessive usage of the corticosteroid medication tablet Betamethasone, which he was taking for a cough and cold related to his chronic obstructive pulmonary disease (COPD). Case Presentation: A 50-year-old Indian male patient with osteoporosis, drug-induced adrenal insufficiency, and bilateral pleural effusion who is receiving anti-tuberculosis therapy which he is on now is presented to the outpatient department of a tertiary hospital with complaints of fever associated with shivering on & off for 4 months, generalized tiredness. He had a history of loose stools for 2-3 days, small joint pain, left knee joint pain and swelling, loss of weight, and loss of appetite. Conclusion: The right diagnosis, treatment, patient counseling, diet, and family support helped him recover despite his turbulent recovery phase. As far as steroid therapy is concerned, it is a double-edged sword, meaning that taking (OTC) over-the-counter steroid drugs without first seeking adequate medical advice could have serious negative effects.

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Multiple drugs

2021

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A rare case of tuberculosis-induced hypercalcemia

Cited by 4 publications

References 15 publications

Clinical Features, Biochemical Parameters, and Treatment Adherence of Individuals Who Started the Treatment for Active Pulmonary Tuberculosis during the Pandemic Period

Clinical Features, Biochemical Parameters, and Treatment Adherence of Individuals Who Started the Treatment for Active Pulmonary Tuberculosis during the Pandemic Period

Rare Presentation of Disseminated Tuberculosis in the Present Era of Modern Tuberculosis Management

Multiple drugs

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