A rare case of transverse vaginal septum

Jain, Vaishali

doi:10.5455/ijmsph.2017.20062016562

Cited by 3 publications

(3 citation statements)

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“…[ 11 ] 2012 1 Female 74 Abdominal pain (LLQ), fatigue, intermittent diarrhea, and weight loss (15 lbs in 2 months) Right-sided tumor; ascending colon Undifferentiated Microsatellite instability Negative CDX-2, CK20, CK7, TTF-1, S-100 protein, MART1, PAX-8, chromogranin, synaptophysin, estrogen receptors, and hepatocyte-specific antigen Jain et al . [ 12 ] 2014 1 Female 72 Bleeding per rectum Abdominal cramps and loose stool Left-sided tumor Poorly differentiated G3 T2N0M0 Microsatellite instability Positive staining for MSH2 and MSH6 Loss of MLH1 and PMS2 protein expression Cunningham et al . [ 13 ] 2014 2 Female 79 Weakness, abdominal pain (RLQ), anorexia, and loss of 11 kg over 1 year Left-sided tumor; splenic flexure Poorly differentiated G4 T3N1M1 Microsatellite instability Positive: CDX-2, rare positive CK7 Negative: CK20, synaptophysin, and chromogranin KRAS wild type and loss of mismatch repair proteins (MLH1 and PMS2) 81 Nausea, vomiting, diarrhea, and weight loss Left-sided tumor; splenic flexure + distal transverse colon Poorly differentiated G2 T4N0M0 Loss of mismatch repair proteins (MLH1 and PMS2) Bağ et al .…”

Section: Discussionmentioning

confidence: 99%

Colonic medullary carcinoma: an exceedingly rare type of colorectal malignancy: a case report and review of the literature

Al-Ishaq,

Al-Dhaheri,

Toffaha

et al. 2023

J Med Case Reports

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Background Medullary carcinoma of the colon is a rare subtype of colorectal cancer that has a unique, and sometimes varied, clinical and histologic profile. It usually presents in adult patients older than 50 years. Here, we report a unique case of young male patient who initially presented with abdominal pain followed by a large bowel obstruction. Case presentation A 40-year-old SriLankan male presented with right-sided abdominal pain and on examination, there was a palpable right iliac fossa mass. Colonoscopy and a computed tomography scan revealed cecal mass. Later, while waiting for elective resection, the patient developed symptoms and signs of a large bowel obstruction. He underwent a laparoscopic right hemicolectomy with an uneventful postoperative course. The histopathologic evaluation of the resected specimens showed invasive carcinoma with syncytial growth pattern, foci of lymphoid host response, and dirty necrosis, in keeping with a medullary carcinoma pT4a pN2b. Unlike most reported medullary carcinoma cases, this patient was young and caudal-related homeobox transcription factor 2 positive. Conclusion We have reported another case of medullary carcinoma of the colon in a young patient with unique histologic characteristics. Reporting such cases helps in refine understanding of the histologic and genetic, as well as clinical, phenotypes of medullary carcinoma of the colon.

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Section: Discussionmentioning

confidence: 99%

Colonic medullary carcinoma: an exceedingly rare type of colorectal malignancy: a case report and review of the literature

Al-Ishaq,

Al-Dhaheri,

Toffaha

et al. 2023

J Med Case Reports

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“…Medullary carcinoma (MCC) of the colon is a recently recognized but rare subtype of colonic adenocarcinoma, with the first published case documented in 1999 [1,2]. It is not to be conflated with breast and thyroid cancers because the clinicopathological features are quite different [3].…”

Section: Introductionmentioning

confidence: 99%

Primary medullary adenocarcinoma of the colon: Literature review and case series

Maung,

Gregory,

De Hoog

et al. 2024

Edorium J Cancer

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Aims: Medullary carcinoma of the colon is a rare subtype of adenocarcinoma, first described in 1999. Clinically known to have a favorably prognosis in comparison to poorly differentiated cancers, it is invariably associated with mismatch gene repair. This is an observational study of Hobart’s patient population with medullary cancer, and compares data with the current literature. Methods: We performed a search of the pathological database at our institution for medullary adenocarcinomas between the years of 2016 and 2023 and reviewed their clinical information to collect all relevant data including patient history, hospital admissions, surgery and clinic visits. We then performed a literature search using PubMed for search terms medullary cancer/carcinoma of the colon/colorectum. Results: Eleven patients were found in our database, 34 papers in the literature (19 retrospective cohort studies and 13 case reports). 81.8% (vs. 73.22% in cohort studies) were females. 8/11 patients had lymphovascular invasion (LVI) with 2/11 patients had perineural involvement (PNI). The immunohistochemistry (IHC) results showed that in all (11/11) patients’ tumors, there was a loss of MLH1 and PMS2 proteins, while MSH2 and MSH6 proteins were present. Cohort studies demonstrated 302/1897 (15.92%) patients had perineural invasion (PNI) with 1133/2151 (52.67%) demonstrating LVI. MLH1 testing was available for 192 patients, with 93.75% having loss of MLH1. Conclusion: Our cohort of medullary cancer patients was similar to that in the literature, with regard to demographic, staging, and tumor characteristics. A longer follow-up time is required for our cohort to produce comparable survival outcomes.

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“…O câncer colorretal se encontra entre as principais causas de morte associada a neoplasias, portanto, adquirir conhecimento sobre esse tumor e seus subtipos, além da relação entre estes e o prognóstico, é de grande relevância 1,2 . Segundo a Organização Mundial de Saúde (OMS) o adenocarcinoma colorretal pode ser classificado em adenocarcinoma mucinoso, carcinoma medular, carcinoma micropapilar, carcinoma cribriforme, adenocarcinoma serrilhado e carcinoma com células em anel de sinete 3 .…”

Section: Introductionunclassified

Metástase Cutânea De Carcinoma Medular De Cólon: Relato De Caso E Revisão Da Literatura

Esteves de Castro,

Pereira Mendonça,

Walker Vasquez Del-Aguila

et al. 2024

Relatos Casos Cir.

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Introdução: O carcinoma medular é um tipo raro de adenocarcinoma colorretal, correspondendo a menos de 3% dentre todos os tumores nessa localização. Relato de caso: Paciente do sexo masculino, 88 anos, apresentou lesão em região cervical posterior cuja biópsia evidenciou histologia compatível com adenoma metastático. Foi realizada investigação com PET-CT, que evidenciou espessamento parietal hipermetabólico do cólon ascendente, fortemente sugestivo de neoplasia primária e também uma colonoscopia, em que foi visualizada uma lesão ulcerada, vegetante, infiltrativa e semi-oclusiva, com aspecto endoscópico típico de adenocarcinoma em cólon ascendente. O paciente foi submetido a uma hemicolectomia oncológica por via laparoscópica de forma assertiva e com resultados satisfatórios. O exame anatomopatológico da peça cirúrgica evidenciou um carcinoma medular com infiltração angiolinfática. Conclusão: Mesmo com os avanços propedêuticos na atualidade, o diagnóstico de alguns tipos raros de tumores continua desafiador. Palavras-chave: Carcinoma Medular. Neoplasias colorretais. Metástase Neoplásica. Colectomia. Relatos de Casos.

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A rare case of transverse vaginal septum

Cited by 3 publications

References 0 publications

Colonic medullary carcinoma: an exceedingly rare type of colorectal malignancy: a case report and review of the literature

Colonic medullary carcinoma: an exceedingly rare type of colorectal malignancy: a case report and review of the literature

Primary medullary adenocarcinoma of the colon: Literature review and case series

Metástase Cutânea De Carcinoma Medular De Cólon: Relato De Caso E Revisão Da Literatura

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