A rare case of syringocystadenocarcinoma papilliferum of the breast: An institutional retrospective case review and brief literature review

Abstract

Syringocystadenocarcinoma papilliferum (SCACP) is a rare cutaneous adnexal tumor thought to originate from its benign counterpart, syringocystadenoma papilliferum.These tumors are predominantly located on the head and neck with their location on the breast extraordinarily reported; mammary localization poses a great diagnostic dilemma to the practicing pathologist. Herein, we report an unusual case of an 85-year-old woman with an outside diagnosis on a core needle biopsy of metaplastic mammary carcinoma. Upon consultative review of the partial mastectomy specimen, SCACP was identified. Herein, we review SCACP and the diagnostic challenge it poses, especially when localized to the breast. Furthermore, we perform a retrospective review of institutional pathology reports and identified four additional cases of SCACP diagnosed at our institution within the last decade. Finally, we briefly review the literature of SCACP. The entity of SCACP should be well known to pathologists to avoid misdiagnosis.

Enlarging facial tumor in a teenager

“…While SCAP is a benign tumor, syringocystadenocarcinoma papilliferum (SCACP), the malignant counterpart, should be considered. In adults, the majority of SCACP have been reported on the head and neck region with extraordinary reports of SCACP to the breast and vulva 8,9 . Of the cases reported, approximately 17% of head and neck lesions resulted in metastatic progression 10 .…”

“…In adults, the majority of SCACP have been reported on the head and neck region with extraordinary reports of SCACP to the breast and vulva. 8,9 Of the cases reported, approximately 17% of head and neck lesions resulted in metastatic progression. 10 Cases of SCACP in pediatric patients have not been reported.…”