A rare case of spleenic hydatidosis in a buffalo: patho-morphological study

Sreedevi, C.; Devi, M. Anitha; Annapurna, P.; Devi, V. Rama

doi:10.1007/s12639-014-0474-y

Cited by 4 publications

(5 citation statements)

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“…Anitha Devi et al (2011) showed fibrous connective tissue surrounded the hydatid cyst in lung of buffaloes. Sreedevi et al (2016) showed fibrous connective tissue around the hydatid cyst in spleen of buffaloes. The hydatid cysts causes severe and chronic inflammation in lung tissue of human, therefore, the proliferation of blood vessels may be contribute in healing and in the formation of granulation tissue against hydatid cyst.…”

Section: Discussion:-mentioning

confidence: 96%

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The Study of Histopathological Changes in Some of Intermediate Hosts Infected With Cystic Echinococcosis

2019

University of Thi-Qar Journal of Science

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The present study aimed to investigate the histopathological changes in liver and lung of sheep, cattle and buffaloes, spleen of cattle and lung of human infected with cystic echinococcosis (Hydatidosis). The infected organs with hydatid cysts were collected from abattoir of Nassiriyah municipality in Thi-Qar province, southern of Iraq and preserved immediately in 10% formalin solution. The gross examination noticed that liver and lung more affected organs with infection of cystic echinococcosis, also harden area was observed around the hydatid cyst and all these cysts were unilocular. The present study showed that the defensive response of hosts represented by formation of massive fibrous layer which surrounded the hydatid cysts in liver, lung and spleen of sheep, cattle and buffaloes. The fibrosis surrounded the hydatid cyst in lung of human was noticed in this study, also the blood vessels in lung were affected by complications of hydatid cyst. The infiltration of inflammatory cells against expanding cysts was observed in liver of sheep and cattle infected with hydatid cysts. The calcification associated with fibrosis in liver of cattle and buffaloes infected with hydatid cysts was noticed while did not demonstrate in liver of sheep. The degeneration of hepatocytes and enlargement of bile duct was recorded in infected cattle. The histopathological changes in lungs of infected hosts represented by the dilatation of pulmonary alveoli in lung of sheep and cattle, also the cystic echinococcosis is affected on the bronchiole by proliferation of bronchial epithelium in cattle. The massive fibrosis enclosed the bronchiole was observed in buffaloes, in addition to fibrosis in the bronchiole. The histopathological alterations in spleen of cattle infected with hydatid cyst represented by fibrosis and calcification surrounded the white pulp and distortion of lymphoid tissue.

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Section: Discussion:-mentioning

confidence: 96%

“…The present findings were agreed with finding of Vural et al (2005) who recognized fibrous capsule surrounded hydatid cyst in spleen of sheep and necrotic material was existing at the periphery of hydatid cyst. Sreedevi et al (2016) refered to mild depletion of the lymphoid cells in the surrounded white pulp in spleen of buffaloes.…”

Section: Discussion:-mentioning

confidence: 99%

The Study of Histopathological Changes in Some of Intermediate Hosts Infected With Cystic Echinococcosis

2019

University of Thi-Qar Journal of Science

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“…22,23 The spleen, as one of the important immune organs in the human body, has also received attention from researchers regarding splenic injury caused by Echinococcus capsulatus cyst fluid, and some studies have shown that both encapsulation can cause T A B L E 1 The KEGG pathways involved in the miRNAs target genes. splenic injury in buffaloes and patients, 24,25 but studies on splenic allergic reactions caused by Echinococcus capsulatus cyst fluid are still rare, so we would like to investigate what kind of differential miRNAs are expressed in the spleen to participate in the occurrence of systemic inflammatory response, and whether such differential miRNAs are involved in some mechanisms of organ damage related to inflammatory response. The PPI network interaction diagram revealed that IL-6 was regulated by miR-146a-5p and miR-149-5p, while IL-10 was regulated by miR-29b-3p and miR-29c-3p.…”

Section: Discussionmentioning

confidence: 99%

“…Usually, the allergic reaction caused by Echinococcus capsulatus cyst fluid is a systemic validated reaction whose target organs are usually the lungs, liver, and other organs. 22 , 23 The spleen, as one of the important immune organs in the human body, has also received attention from researchers regarding splenic injury caused by Echinococcus capsulatus cyst fluid, and some studies have shown that both encapsulation can cause splenic injury in buffaloes and patients, 24 , 25 but studies on splenic allergic reactions caused by Echinococcus capsulatus cyst fluid are still rare, so we would like to investigate what kind of differential miRNAs are expressed in the spleen to participate in the occurrence of systemic inflammatory response, and whether such differential miRNAs are involved in some mechanisms of organ damage related to inflammatory response.…”

Section: Discussionmentioning

confidence: 99%

The regulatory role of differential microRNA expressions on cellular inflammatory factors IL‐6 and IL‐10 in Echinococcus granulosus‐induced anaphylaxis

Wang,

Yu,

Kulaixi

et al. 2023

Immunity Inflam & Disease

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ObjectiveTo determine the pathogenesis and molecular targets of anaphylaxis caused by hydatid cyst fluid leakage.MethodsFirst, Balb/c mice were infected with Echinococcus granulosus, and then the anaphylaxis model was developed. The mice were separated into: anaphylaxis caused by the cystic echinococcosis group (ANPC), the cystic echinococcosis without anaphylaxis group (CE group), and the normal control group (CTRL). Following this, the spleen tissue was collected for microRNA (miRNA) sequencing. Using bioinformatics analysis, differentially expressed miRNAs (DEMs) were identified. Then, through the use of protein–protein interaction (PPI) networks, the key target genes for miRNA regulation associated with echinococcosis‐induced anaphylaxis were identified.ResultsANPC and CE groups have 29 and 39 DEMs compared to the CTRL group, respectively. Based on these 25 DEMs, interactions between miRNA and mRNA were screened, and 174 potential target genes were identified. We performed gene ontology (GO) function and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis on these 174 target genes, and the results revealed that the three pathways with the highest enrichment were the PI3K‐Akt signaling pathway, FoxO signaling pathway, and Focal adhesion. The interaction analysis of PPI and miRNA‐hub gene networks revealed that interleukin 6 (IL‐6) was regulated by miR‐146a‐5p and miR‐149‐5p, while IL‐10 was regulated by miR‐29b‐3p and miR‐29c‐3. Using reverse transcription polymerase chain reaction, we found that the miRNAs regulating IL‐6 and IL‐10 were significantly upregulated in the ANPC group, and there are three pathways involved in that process: Pathways of PI3K‐Akt signaling, FoxO signaling, and Focal adhesion. IL‐6 and IL‐10 play an important role in cellular pyroptosis and apoptosis. Therefore, the aforementioned results provide significant reference value for elucidating the mechanism of cellular pyroptosis and apoptosis in echinococcosis‐induced anaphylaxis, and for formulating tissue and organ protection strategies for patients with cystic echinococcosis when anaphylaxis is triggered by hydatid cyst rupture.

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“…Incidence of hydatidosis in buffaloes was found to be 30.61% in Andhra of Pradesh [20] and 10% in animals slaughtered at Chennai, Tamil Nadu [21]. Naik [22] observed a higher infection rate in females than the male animals from necropsied sheep and goats during a period of one year.…”

Section: Indiamentioning

confidence: 98%

Epidemiology and Public Health Significance of Hydatidosis: A Review

Mathivathani,

Ajaykumar,

Bora

2023

CJAST

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Echinococcus granulosus is an important dog tape worm whose larval stage causes hydatidosis in animals and man. The objective of this review on hydatidosis is to get a comprehensive knowledge about the disease and it had included the data of past 10 years collected from various scientific articles. Food animals such as sheep, goat, cattle etc. act as its intermediate host. It is a major parasitic zoonosis having high economic loss and public health significance and high worldwide prevalence rate. There are different strains of E. granulosus from G1 to G10 which is distributed worldwide infecting various animals and humans. The tapeworm in dogs causes fewer ill effects but in food animals it affects liver, lungs and spleen which lead to condemnation of meat thereby affecting economic value of meat. In humans it causes severe disease mainly cystic echinococcosis and alveolar echinococcosis in addition to two forms of neotropical echinococcosis namely polycystic echinococcosis and unicystic echinococcosis. Diagnosis and treatment of hydatidosis in animals is practically difficult and uneconomical but more promising in human medicine due to advanced techniques. The role of stray dogs in the maintenance of the life cycle of parasite is important hence health education and public awareness are very essential in the control of echinococcosis.

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A rare case of spleenic hydatidosis in a buffalo: patho-morphological study

Cited by 4 publications

References 4 publications

The Study of Histopathological Changes in Some of Intermediate Hosts Infected With Cystic Echinococcosis

The Study of Histopathological Changes in Some of Intermediate Hosts Infected With Cystic Echinococcosis

The regulatory role of differential microRNA expressions on cellular inflammatory factors IL‐6 and IL‐10 in Echinococcus granulosus‐induced anaphylaxis

Epidemiology and Public Health Significance of Hydatidosis: A Review

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