A Rare Case of Solitary Giant Congenital Juvenile Xanthogranuloma: A Case Report

Vignault, Catherine; Bourgeault, Emilie; Gagné, Éric; Bujold, Janie

doi:10.1177/1203475417690718

Cited by 7 publications

(12 citation statements)

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“…To our knowledge, 51 cases of giant JXG have been reported in the English literature. 8,10-50 We analyzed all cases of giant JXG for various characteristics. In our analysis, we also compared giant JXG and classic JXG (Table 1).…”

Section: Discussionmentioning

confidence: 99%

Giant Juvenile Xanthogranuloma: Case Report, Literature Review, and Algorithm for Classification

Ladha

Haber

2018

J Cutan Med Surg

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Juvenile xanthogranuloma (JXG) is a member of the non-Langerhans cell group of proliferative disorders of mononuclear phagocytes. JXG is a benign tumour of histiocytic cells. Classic JXG is divided into 2 main clinical subtypes: dome-shaped papules (<0.5 cm) and single/multiple nodules (<2.0 cm). A rare variant is referred to as giant; this term encompasses JXG lesions larger than 2.0 cm. In this article, we report a case of a congenital cutaneous giant JXG. In addition, we reviewed and analyzed all cases (n = 51) of giant JXG reported in the English literature. We propose an algorithm for classifying giant JXG based on the following factors: onset of lesions (congenital and acquired), number of lesions (solitary ± satellites and multiple), morphology of cutaneous/mucosal lesions (plaque, nodular, ulcerated-nodular, macular, and other), and extracutaneous manifestations.

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Section: Discussionmentioning

confidence: 99%

Giant Juvenile Xanthogranuloma: Case Report, Literature Review, and Algorithm for Classification

Ladha

Haber

2018

J Cutan Med Surg

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“…Lesions are typically small, with only a handful of reported cases larger than 20 mm—referred to as giant JXGs . There is no evidence that these behave differently from non‐giant JXGs, although presentation is atypical, and lesions are often described clinically as isolated vascular masses with a pale or yellowish center …”

Section: Discussionmentioning

confidence: 99%

“…The characteristic Touton cell contains a “wreath” of nuclei surrounded by foamy cytoplasm. Immunohistochemistry in JXG is typically positive for CD68 and Factor XIIIa and negative for S‐100, helping to distinguish from LCH, which is usually positive for CD1a, Langerin, and S‐100 …”

Section: Discussionmentioning

confidence: 99%

Solitary lesion of a newborn's foot

Maslin

Hook

Burrows

2018

Pediatric Dermatology

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A 4-month-old boy was born with a small, flat, violaceous lesion on the sole of his right foot that grew steadily in size from birth. This was referred to our clinic as an ulcerated hemangioma. On examination, there was a solitary, nontender, firm, sharply marginated lesion with a purplish rim and central ulceration (Figure 1) measuring 24 by 13 by 33 mm on ultrasound. The patient underwent magnetic resonance imaging (MRI) and biopsy for histopathologic analysis (Figures 2 and 3).

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“…Die Riesenvariante der kongenitalen JXG ist sehr selten; es gibt in der Literatur nur sehr wenige Berichte darüber [5][6][7][8][9][10]. Sie wird als eine Läsion definiert, die grösser als 2 cm ist und ähnliche klinische und histopathologische Merkmale wie das klassische JXG aufweist, mit Ausnahme des bereits erwähnten höheren Risikos einer extrakutanen Beteiligung.…”

Section: Diskussionunclassified