A rare case of renal gastrointestinal stromal tumor

Karlıdağ, İsmail; Özbay, Engin; Colakerol, Aykut; Dizibuyuk, Omer Faruk; Yenigürbüz, Serkan; Özyuvalı, Ekrem

doi:10.1016/j.eucr.2019.100881

Cited by 3 publications

(2 citation statements)

References 5 publications

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“…This was the first case of EGIST originating from the pericardium. Reports of EGIST presenting in the kidney, adrenal gland, inferior vena cava, vagina, and scrotum have been found [9][10][11][12][13]. Diagnosis can often be delayed due to small tumor size and lack of clinical symptoms in the tumor's early stages [1,8].…”

Section: Discussionmentioning

confidence: 99%

Primary Gastrointestinal Stromal Tumor Presenting as an Isolated Lung Mass

Mootz

Nguyễn

Poddar

et al. 2020

Cureus

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Gastrointestinal stromal tumors (GISTs) are rare gastrointestinal (GI) tumors, representing a small portion of soft tissue tumors of the abdominal cavity. Extraintestinal gastrointestinal stromal tumors (EGISTs) are uncommon forms of GISTs that present outside the GI tract. There have only been a rare number of reported cases of EGIST presenting above the diaphragm. We present the case of a 50-year-old female with shortness of breath, and found to have bilateral pleural effusions and left-sided lung mass. The initial lung mass aspiration was negative for malignancy; yet, pleural fluid was suggestive of malignancy, and repeat biopsy and immunohistochemical stain were diagnostic for GIST. Ultimately, the patient underwent videoassisted thoracoscopic surgery, pleurodesis with doxycycline, and adjuvant therapy with imatinib. This is a report of primary EGIST presenting as an isolated lung lesion with no involvement of the GI tract. In patients with suspected malignancy, it is of paramount importance to obtain a detailed history, including remote signs and symptoms, while performing a thorough work-up. Especially in the lung where initial biopsies can be skewed due to inflammation and atelectasis, repeat biopsies may be necessary to obtain an accurate diagnosis.

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Section: Discussionmentioning

confidence: 99%

Primary Gastrointestinal Stromal Tumor Presenting as an Isolated Lung Mass

Mootz

Nguyễn

Poddar

et al. 2020

Cureus

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“…Several studies reported the association between GIST and second primary malignancies. Next to other gastrointestinal tumors, genitourinary cancer is associated with GIST [2][3][4][5][6]. In many cases, the association is related to KIT mutations [7,8].…”

Section: Introductionmentioning

confidence: 99%

Association of Genitourinary Cancer Among Patients with Gastrointestinal Stromal Tumor: A Unique Pattern in a Tertiary Care Saudi Cohort

Seyam

Chaer

Abouelkhair

et al. 2022

Preprint

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Purpose The gastrointestinal tract's most commonly occurring primary mesenchymal tumor is the gastrointestinal stromal tumor (GIST). However, few cases worldwide were reported associated with renal cell carcinoma (RCC). Therefore, we aimed to identify the association of genitourinary tumors in patients with GIST in our tertiary care hospital in Saudi Arabia. Methods We identified all patients in the pathology department database with the diagnosis of GIST. We excluded duplicate and recurrent cases. We examined patients’ files for the presence of RCC, adrenal tumors, or other genitourinary cancer. Results From 2003 to 2022, 170 patients had a histopathologic diagnosis of primary GIST, 100 men and 70 women, median age of 63 (± 15.5) years at the time of diagnosis. The site of primary GIST was gastric 103, small bowel 43, mesenteric 5, omentum/peritoneum 7, abdomen 4, isolated adrenal 1, and other 7. Eight patients had associated genitourinary cancer. Three patients had RCC (two clear cell RCC and one radiologic diagnosis only), three had adrenal tumors (one adrenal carcinoma, one an isolated adrenal GIST and one pheochromocytoma), and two had a tumor invading the urinary bladder. Although the cohort included 63 men aged 60 years old or above (median 71 ± 8.7 years, range 60–94), none demonstrated clinical prostatic carcinoma. Conclusion We report the rare association between GIST tumors and primary genitourinary cancer, mainly RCC and adrenal tumors. Also, we identified a secondary invasion of the urinary bladder. Unlike the reported series, none of the older male patients had clinical prostate cancer.

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The association of genitourinary cancer among Saudi patients with gastrointestinal stromal tumors and a systematic literature review

Seyam

Chaer

Abouelkhair

et al. 2023

Sci Rep

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The gastrointestinal tract's most commonly occurring primary mesenchymal tumor is the gastrointestinal stromal tumor (GIST). However, few cases worldwide were reported associated with renal cell carcinoma (RCC). Therefore, we aimed to identify the association of genitourinary tumors in patients with GIST in our tertiary care hospital in Saudi Arabia and compare it to the literature. We identified all patients in the pathology department database with the diagnosis of GIST. We excluded duplicate and recurrent cases. We examined patients’ files for the presence of RCC, adrenal tumors, or other genitourinary cancer. A systematic review of the association was conducted. From 2003 to 2020, 170 patients had a histopathologic diagnosis of primary GIST, 100 men and 70 women, median age of 57 (range 9–91) years at the time of diagnosis. The site of primary GIST was gastric 103, small bowel 43, mesenteric 5, omentum/peritoneum 7, abdomen 4, isolated adrenal 1, and other 7. Six patients had associated primary genitourinary cancer. Three patients had RCC (two clear cell RCC and one radiologic diagnosis only), and three had adrenal tumors (one adrenal carcinoma, one an isolated adrenal GIST, and one pheochromocytoma). In addition, two patients had a tumor invading the urinary bladder. Although the cohort included 63 men aged 60 or above (median 71 ± 8.7 years, range 60–94), none demonstrated clinical prostatic carcinoma. Data was compared to 69 systematic review articles. We report the rare association between GIST tumors and primary genitourinary cancer, mainly RCC and adrenal tumors. Also, we identified a secondary invasion of the urinary bladder. Unlike the reported series, none of the older male patients had clinical prostate cancer.

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A rare case of renal gastrointestinal stromal tumor

Cited by 3 publications

References 5 publications

Primary Gastrointestinal Stromal Tumor Presenting as an Isolated Lung Mass

Primary Gastrointestinal Stromal Tumor Presenting as an Isolated Lung Mass

Association of Genitourinary Cancer Among Patients with Gastrointestinal Stromal Tumor: A Unique Pattern in a Tertiary Care Saudi Cohort

The association of genitourinary cancer among Saudi patients with gastrointestinal stromal tumors and a systematic literature review

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