A rare case of primary orofacial granulomatosis of gingiva during pregnancy

Abstract

Orofacial granulomatosis (OFG) comprises a group of diseases characterized by noncaseating granulomatous inflammation affecting the soft tissues of the oral and maxillofacial region. It is important to establish the diagnosis accurately because this condition is sometimes a manifestation of many systemic conditions like Crohn's disease or sarcoidosis. The clinical outcome of OFG patients continues to be unpredictable. Current therapies remain unsatisfactory. This article reports a rare case of isolated OFG with langhans type giant cells and inflammatory infiltrate without any systemic involvement, in which the condition was a manifestation of pregnancy. The diagnostic approach to and the treatment of OFG are reviewed.

Primary orofacial granulomatous involvement of lip and gingiva only: A diagnostic challenge

“…Tooth-associated infections, allergy to dental materials such as amalgam fillings, hygiene products, food additives, or contact allergens have been reported as causative agents. [ 5 ] Food preservatives containing benzoates, cinnamon, chocolate as well as products containing glitter (lip gloss), perfumes, and flavorings, have been proposed as potential triggers for OFG. [ 6 ]…”