A Rare Case of Primary Cutaneous Follicle Center Lymphoma Mimicking Leprosy

Abstract

Cutaneous B-Cell Lymphoma is a rare type of cutaneous lymphoma with a plethora of clinical manifestations ranging from macules, papules, nodules, or plaques. The lesions are often painless and certain subtypes such as the primary cutaneous follicle center lymphoma (PCFCL) are indolent. The disease is often misdiagnosed with other dermatoses including bacterial and fungal infections. Here we report a 55-year-old female patient with clinical manifestations resembling multibacillary leprosy that was then confirmed to be PCFCL through aid of dermoscopy and histopathology. The patient then undergone chemotherapy using the R-CHOP regiment which resulted in significant clinical improvement and no signs of metastases or extracutaneous involvement upon follow-up.

A patient with multiple nodules and plaques on forehead, cheeks and chin

“…Furthermore, the dermis of HD would reveal nodular, granulomatous, inflammatory infiltrate composed primarily of foamy histiocytes with scattered lymphocytes as compared with diffuse dermal infiltrates seen in the superficial and deep dermis and germinal centre formation in cutaneous lymphoma. In a case report by Made et al 6 a 55‐year‐old female patient came in with 3 year duration of erythematous plaque on the face with erythematous nodule on left ear resembling multibacillary leprosy but later confirmed to be PCFCL through the aid of immunohistochemistry.…”