A rare case of perimyocarditis induced by all-trans retinoic acid administration during induction treatment of acute promyelocytic leukemia

Makki, Abdelilah Ben El; Mahtat, El Mehdi; Kheyi, Jamal; Balkhi, H.; Chaib, Ali

doi:10.15386/mpr-1229

Cited by 4 publications

(2 citation statements)

References 8 publications

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“… 3 Cases of myopericarditis with concurrent pericardial effusions have been reported in the setting of ATRA or ATO therapy. 4 , 5 …”

Section: Discussionmentioning

confidence: 99%

Successful Treatment of Recurrent Pericarditis With Rilonacept in Acute Promyelocytic Leukemia

Atar,

Majid,

Yaker

et al. 2023

JACC: Case Reports

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“… 3 Cases of myopericarditis with concurrent pericardial effusions have been reported in the setting of ATRA or ATO therapy. 4 , 5 …”

Section: Discussionmentioning

confidence: 99%

Successful Treatment of Recurrent Pericarditis With Rilonacept in Acute Promyelocytic Leukemia

Atar,

Majid,

Yaker

et al. 2023

JACC: Case Reports

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“…( 2 ) 2011 39, female 18 38 Basal and midanterior Dexamethasone and diuretic No change Ben El Makki et al. ( 3 ) 2019 27, male 10 33 Diffuse Vasopressors, diuretic, ACE inhibitor, beta blocker Diffuse ST-segment elevation Klein et al. ( 4 ) 2007 34, female 19 No data No data No specific treatment Diffuse ST-segment elevation Klein et al.…”

Section: Discussionmentioning

confidence: 99%

All-trans Retinoic Acid–Induced Isolated Myocarditis

et al. 2020

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All- trans retinoic acid (ATRA) is the mainstay of treatment in patients with acute promyelocytic leukemia. Despite being effective, it can lead to cardiac complications either as a component of ATRA syndrome or an isolated form denominated as ATRA-induced isolated perimyocarditis. We present a case of this complication and review the literature. ( Level of Difficulty: Intermediate. )

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Differentiation syndrome-induced Myopericarditis in the induction therapy of acute Promyelocytic leukemia: a case report

et al. 2021

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Background All trans retinoic acid (ATRA) has revolutionized the treatment and outcomes of patients with Acute Promyelocytic Leukemia (APL). Induction therapy with ATRA is associated with the rare but potentially fatal complication of differentiation syndrome. While the presentation of this syndrome is varied, myopericarditis as a manifestation of differentiation syndrome is often fatal and rarely reported in literature. We present a case of myopericarditis as the sole manifestation of differentiation syndrome in a patient on induction therapy with ATRA and arsenic trioxide for APL. Clinical presentation A 62 year old woman with remote history of breast and uterine cancer presented to the hospital for expedited work up of easy bruising and expanding hematomas. She was diagnosed with APL with peripheral blood and bone marrow cytogenetics revealing t (15;17) translocation and initiated on induction therapy with ATRA and ATO as well as steroids for differentiation syndrome prophylaxis. Eighteen days into induction therapy, patient developed pleuritic chest pain, elevated cardiac biomarkers, ECG changes suggestive of pericarditis. Cardiac magnetic resonance imaging showed patchy multifocal sub-epicardial late gadolinium enhancement and elevated T2 signal consistent with acute myopericarditis. Given the timing of symptom onset and lack of other identifiable cause, patient was diagnosed with differentiation syndrome- induced myopericarditis and promptly initiated on high dose steroids with rapid improvement in symptoms, ECG, and cardiac biomarkers. Patient successfully resumed dose-reduced ATRA and arsenic trioxide without complication. Conclusion Myopericarditis can be the sole manifestation of differentiation syndrome and the presentation may be atypical owing to the use of prophylactic steroids as illustrated in our patient’s case. A high index of suspicion for differentiation syndrome, multimodality imaging, and prompt input from multidisciplinary providers is crucial for making the timely diagnosis and initiating life-saving treatment.

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A rare case of perimyocarditis induced by all-trans retinoic acid administration during induction treatment of acute promyelocytic leukemia

Cited by 4 publications

References 8 publications

Successful Treatment of Recurrent Pericarditis With Rilonacept in Acute Promyelocytic Leukemia

Successful Treatment of Recurrent Pericarditis With Rilonacept in Acute Promyelocytic Leukemia

All-trans Retinoic Acid–Induced Isolated Myocarditis

Differentiation syndrome-induced Myopericarditis in the induction therapy of acute Promyelocytic leukemia: a case report

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